2024
DOI: 10.3390/ijms252212084
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Expression of Network Medicine-Predicted Genes in Human Macrophages Infected with Leishmania major

Felipe Caixeta,
Vinicius Dantas Martins,
Amanda Braga Figueiredo
et al.

Abstract: Leishmania spp. commonly infects phagocytic cells of the immune system, particularly macrophages, employing various immune evasion strategies that enable their survival by altering the intracellular environment. In mammals, these parasites establish persistent infections by modulating gene expression in macrophages, thus interfering with immune signaling and response pathways, ultimately creating a favorable environment for the parasite’s survival and reproduction. In this study, our objective was to use data … Show more

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