Expression of nicotinic receptors in the skin of patients with palmoplantar pustulosis

Abstract

Smoking can influence nAChR expression. The altered nAChR staining pattern in PPP skin may indicate a possible role for nicotine in the pathogenesis of PPP. We hypothesize that there is an abnormal response to nicotine in patients with PPP, resulting in inflammation.

Mechanisms of nicotine-induced cutaneous vasodilation and sweating in young adults: roles for KCa, KATP, and KVchannels, nitric oxide, and prostanoids

“…This exclusive role of muscarinic receptors in nicotinic sweating is in contrast to nicotinic cutaneous vasodilation wherein there is a muscarinic-insensitive component of nicotinic cutaneous vasodilation (see above). This difference may infer that nicotinic receptors located on sweat glands (Hagforsen et al 2002) do not functionally modulate sweating whereas those on skin vessels (Hagforsen et al 2002) modulate cutaneous vasodilation.…”

“…It is likely that the nicotine infusion activated nicotinic receptors located on endothelial cells of the cutaneous blood vessels (Hagforsen et al 2002), which subsequently activated COX also located in the endothelial cells (Muller-Decker et al 1999). The activation of COX by nicotine may increase superoxide production from COX itself (Egan et al 1976), or NADPH oxidase (Zhang et al 2011).…”

“…Hence this response may be due to the activation of nicotinic receptors expressed on the endothelial cells of cutaneous blood vessels (Hagforsen et al 2002) Finally, nicotine may activate K ATP channels through increasing superoxide production as demonstrated under in vitro conditions (Hanna et al 2005). …”

Dermatoses neutrofílicas: parte II

“…60 Furthermore, nicotinic receptors expression is altered in the epidermis of patients with PPP, and nicotine would lead to an inflammatory response with altered expression of acetylcholinesterase (acetylcholine degrading enzyme), resulting in lesions of PPP. 70 The triggering mechanism of inflammation is unknown. 71 Contactants may play a role in the etiopathogenesis of PPP, although the prevalence of positive patch tests varies.…”

“…69 Sudoresis and the glandular apparatus appear to play an important role in the pathogenesis of PPP. 70 Some studies have shown the presence of an abnormal portion of the acrosyringium in the epidermis of patients with PPP, suggesting its participation in the etiopathogenic process of pustule formation. 60 Furthermore, nicotinic receptors expression is altered in the epidermis of patients with PPP, and nicotine would lead to an inflammatory response with altered expression of acetylcholinesterase (acetylcholine degrading enzyme), resulting in lesions of PPP.…”