Expression of NK cells activation receptors after occupational exposure to toxics

Célis, Ruth De; Feria‐Velasco, Alfredo; Bravo-Cuéllar, Alejandro; Hicks-Gómez, Juan José; García-Iglesias, Trinidad; Preciado-Martínez, Verónica; Muñoz-Islas, Laura; González-Unzaga, Marco

doi:10.1016/j.imlet.2008.03.010

Cited by 6 publications

(3 citation statements)

References 48 publications

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“…Environmental pollution and the exposure of the human population to daily toxic chemicals tend to decrease immune function and function in particular NKCs activity. 34 Whether homoeopathic approach can enhance the activity of the immune system is a subject of considerable debate. 35 Moreover, in many of the advanced cancer patients, the quality of life deteriorates because of difficult symptoms of cancer and adverse effects of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Stimulation of natural killer cells by homoeopathic complexes: An in vitro and in vivo pilot study in advanced cancer patients

Simos

Bougiouklis²,

Oikonomidis

2013

Cell Biochemistry & Function

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The present study was designed in order to evaluate the effects of five homoeopathic complex preparations on functional activity natural killer cells (NKCs) in advanced cancer patients. We examined the effects of Coenzyme Compositum®, Ubichinon Compositum®, Glyoxal Compositum®, Katalysatoren® and Traumeel® on the functional activity of NKCs. Experimental procedures included in vitro and in vivo trials. The in vitro trials were performed in NKCs isolated from 12 healthy volunteers (aged 44 ± 4 years) and incubated with the five homoeopathic complex preparations. The in vivo trials were performed in 15 advanced cancer patients (aged 55 ± 12 years) supplemented for 3 months with the homoeopathic preparations. All five homoeopathic preparations significantly increased the cytotoxic activity of the NKCs at the lowest NKCs/target cell ratio 12:1 (p < 0·05). The order of activity was: Ubichinon Compositum® > Glyoxal Compositum® > Katalysatoren® > Traumeel® > Coenzyme Compositum®. In the advanced cancer patients, the homoeopathic preparation significantly increased NKCs cytotoxic activity (p < 0·05). The homoeopathic complex preparations tested in this study can be used as an adjuvant immunotherapy in advanced cancer patients.

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Section: Discussionmentioning

confidence: 99%

“…Environmental pollution and the exposure of the human population to daily toxic chemicals tend to decrease immune function and function in particular NKCs activity . Whether homoeopathic approach can enhance the activity of the immune system is a subject of considerable debate .…”

Section: Discussionmentioning

confidence: 99%

Stimulation of natural killer cells by homoeopathic complexes: An in vitro and in vivo pilot study in advanced cancer patients

Simos

Bougiouklis²,

Oikonomidis

2013

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

“…Others contend that because of the environmental pollution and the exposure of the human population to daily toxic chemicals, immune function, and NK function in particular, tends to be decreased significantly (De Celis et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

NK cell stimulation by administration of vitamin C and Aloe vera juice in vitro and in vivo: A pilot study

Simos

Verginadis

Oikonomidis

et al. 2012

Journal of Herbal Medicine

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The role of catechols and free radicals in benzene toxicity: An oxidative DNA damage pathway

Barreto

Madureira

Capani

et al. 2009

Environ and Mol Mutagen

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Benzene is a widespread volatile compound and an environmental contaminant. Since it causes important toxic effects in workers exposed to low levels, long-term exposure to this compound has been extensively studied. Leukemia, blood disorders, bone marrow depression, and some types of cancer are directly related to benzene-initiated toxicity. Bioactivation of benzene can lead to the formation of hazardous metabolites such as phenol, hydroquinone, and catechol. Catechol forms semiquinones and reactive quinones that are presumed to play an important role in the generation of reactive oxygen species (ROS). ROS formation can directly induce single and double strand breaks in the DNA, oxidized nucleotides, and hyper-recombination, and consequently produces deleterious genetic changes. In this review, we have addressed the cytotoxic effects of benzene and its main metabolite, catechol, focusing on the oxidative pathway and further DNA damage.

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Expression of NK cells activation receptors after occupational exposure to toxics

Cited by 6 publications

References 48 publications

Stimulation of natural killer cells by homoeopathic complexes: An in vitro and in vivo pilot study in advanced cancer patients

Stimulation of natural killer cells by homoeopathic complexes: An in vitro and in vivo pilot study in advanced cancer patients

NK cell stimulation by administration of vitamin C and Aloe vera juice in vitro and in vivo: A pilot study

The role of catechols and free radicals in benzene toxicity: An oxidative DNA damage pathway

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