Expression of Notch and Wnt/β-catenin signaling pathway in acute phase severe brain injury rats and the effect of exogenous thyroxine on those pathways

Wei, Chenchen; Luo, Yan; Peng, Lifeng; Huang, Zhenguang; Pan, Yuzheng

doi:10.1007/s00068-020-01359-4

Cited by 10 publications

(10 citation statements)

References 16 publications

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“…Moreover, we only found one study on Notch-Wnt signaling in brain injury. The study showed that Wnt3a and β-catenin expression increased significantly seven days post-injury (7dpi) in a model of brain injury in rats, while Notch1 and Hes1 expression increased gradually over time (Wei et al, 2020). The authors suggested a synergistic effect of both pathways on repairing mechanisms in brain injury.…”

Section: Discussionmentioning

confidence: 99%

Contribution of Notch/Wnt signaling modulation in reactive astrocyte reparative response after brain injury

Delgado-García

Benincasa

Courbassier

et al. 2022

Preprint

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After a Traumatic Brain Injury (TBI), the neural network activates a reparative response seeking to restore homeostasis. Astrocyte reactivation is an essential component of this response. The injury creates a temporal microenvironment where neurogenic signaling molecules regulate cell fate decisions of neocortical neural progenitors. Likewise, astrocyte reactivation triggers a transcriptional-proliferative program where neurogenic signaling molecules play crucial roles. However, precise molecular mechanisms are context-specific and are not fully understood. Here we studied cellular and molecular aspects of reactive astrocytes response after Notch-Wnt neurogenic signaling modulation. Our results provide new evidence of cortical Notch-Wnt signaling activation after TBI. Reactive astrocytes in the core of Notch signaling showed a differential aggregated distribution. In vitro, Notch inhibition promoted a neural precursor profile and might increase the number of cells committed in a proliferative response. Finally, we found an indirect co-regulation of Wnt-Shh signaling in BHLH-Notch target genes and a Notch-supportive effect in Wnt-Shh signaling activation.

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Section: Discussionmentioning

confidence: 99%

Contribution of Notch/Wnt signaling modulation in reactive astrocyte reparative response after brain injury

Delgado-García

Benincasa

Courbassier

et al. 2022

Preprint

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“…Importantly, the density and complexity of the microvasculature increased at day 7 after TBI (Jullienne et al, 2018). The mRNA levels of β-catenin and Wnt3a significantly increased following TBI, peaking at day 3 post-TBI for β-catenin and at day 7 for Wnt3a (Wei et al, 2020). Furthermore, several findings have demonstrated that Akt/GSK3β pathway regulates as well β-catenin expression (Zhao et al, 2012).…”

Section: Implication In Tbi Pathobiologymentioning

confidence: 98%

Wnt Pathway: An Emerging Player in Vascular and Traumatic Mediated Brain Injuries

2020

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The Wnt pathway, which comprises the canonical and non-canonical pathways, is an evolutionarily conserved mechanism that regulates crucial biological aspects throughout the development and adulthood. Emergence and patterning of the nervous and vascular systems are intimately coordinated, a process in which Wnt pathway plays particularly important roles. In the brain, Wnt ligands activate a cellspecific surface receptor complex to induce intracellular signaling cascades regulating neurogenesis, synaptogenesis, neuronal plasticity, synaptic plasticity, angiogenesis, vascular stabilization, and inflammation. The Wnt pathway is tightly regulated in the adult brain to maintain neurovascular functions. Historically, research in neuroscience has emphasized essentially on investigating the pathway in neurodegenerative disorders. Nonetheless, emerging findings have demonstrated that the pathway is deregulated in vascular-and traumatic-mediated brain injuries. These findings are suggesting that the pathway constitutes a promising target for the development of novel therapeutic protective and restorative interventions. Yet, targeting a complex multifunctional signal transduction pathway remains a major challenge. The review aims to summarize the current knowledge regarding the implication of Wnt pathway in the pathobiology of ischemic and hemorrhagic stroke, as well as traumatic brain injury (TBI). Furthermore, the review will present the strategies used so far to manipulate the pathway for therapeutic purposes as to highlight potential future directions.

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“…Notch signaling is an evolutionarily conserved pathway that acts as a molecular switch, directing cell fate decisions and regulating tissue homeostasis [80] . Studies exploring the influence of TBIs on the Notch pathway have noted a dynamic relationship between TBI‐induced alterations and bone healing [81] …”

Section: Signaling Pathways In Tbi‐induced Bone Healingmentioning

confidence: 99%

“…[80] Studies exploring the influence of TBIs on the Notch pathway have noted a dynamic relationship between TBI-induced alterations and bone healing. [81] One noteworthy consequence of TBI-induced Notch pathway activation is its impact on osteoblast lineage commitment and differentiation. [82] Through the interplay of ligands and receptors, Notch signaling facilitates the commitment of MSCs to the osteoblast lineage.…”

Section: Notch Signaling Pathwaymentioning

confidence: 99%

The mechanism of bone healing after traumatic brain injury

Xiong,

Zhong,

2023

Brain-X

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A growing body of evidence suggests that patients who experience traumatic brain injuries (TBIs) exhibit significantly shorter healing periods compared to those with isolated fractures. However, the precise underlying mechanism behind this phenomenon remains unclear. Recent studies have shed light on the potential role of hormonal signals and neural circuits originating in the hypothalamus, which play vital roles in regulating the skeletal system. Despite these advances, there is a lack of comprehensive research summarizing the crucial role of bone healing in TBIs and the underlying mechanisms. This review aimed to explore the underlying mechanisms responsible for the accelerated bone healing observed in TBI patients, with a specific focus on the intricate crosstalk between TBI and bone remodeling. Additionally, we comprehensively discuss and summarize the beneficial effects of TBI on the skeletal system and examine the TBI‐induced signaling pathways that result in accelerated fracture healing and bone remodeling. By dissecting these pathways, we aim to identify potential targets for intervention and bone repair promotion.

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Expression of Notch and Wnt/β-catenin signaling pathway in acute phase severe brain injury rats and the effect of exogenous thyroxine on those pathways

Cited by 10 publications

References 16 publications

Contribution of Notch/Wnt signaling modulation in reactive astrocyte reparative response after brain injury

Contribution of Notch/Wnt signaling modulation in reactive astrocyte reparative response after brain injury

Wnt Pathway: An Emerging Player in Vascular and Traumatic Mediated Brain Injuries

The mechanism of bone healing after traumatic brain injury

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