Expression of nuclear XIAP associates with cell growth and drug resistance and confers poor prognosis in breast cancer

Delbue, Deborah; Mendonça, B. S.; Robaina, Marcela Cristina; Lemos, Lauana Greicy Tonon; Lucena, Pedro I.; Viola, João P. B.; Magalhães, Lidia Maria; Crocamo, Susanne; Oliveira, Caio Almeida Batista de; Teixeira, Felipe Roberti; Maia, Raquel Ciuvalschi; Moraes, Gabriela Nestal de

doi:10.1016/j.bbamcr.2020.118761

Cited by 16 publications

(13 citation statements)

References 29 publications

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“…Additionally, the regulatory relationship in network also revealed the direct regulatory effects of cIAP1/2 and XIAP on caspases. As reported in the literature, cIAP1/2 and XIAP participate in anti-apoptotic mechanisms in various cancer cells including breast cancer cells [30][31][32] . cIAP1/2 and XIAP can bind and effectively inhibit caspase-3, caspase-7, and caspase-9 [33][34][35][36] .…”

Section: Effect Of Rjsj On the Cell Cycle Distribution In Breast Cancmentioning

confidence: 67%

“…Intriguingly, genes such as Bcl-2, survivin, caspase-3, caspase-7, and caspase-9 might be the potential targets of RJSJ, as indicated by our previous study 13 . cIAP1/2 and XIAP can bind and effectively inhibit caspase-3, caspase-7, and caspase-9, which participate in the anti-apoptotic mechanisms in various cancer cells including breast cancer cells [30][31][32][33][34][35][36] . The in uence of RJSJ on these proteins was veri ed both in vitro and in vivo, supporting the e ciency of this strategy.…”

Section: Discussionmentioning

confidence: 99%

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Ruanjian Sanjie Decoction Induces Apoptosis in Triple-negative Breast Cancer Cells by Downregulating cIAP1/2 and XIAP

Zhao¹,

Wang²,

Jia³

et al. 2020

Preprint

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Background: Traditional Chinese medicine (TCM) comprises a unique theoretical system developed over thousands of years. The previous study reported that Ruanjian Sanjie (RJSJ) exerts anti-tumor effects by inducing cell apoptosis. However, the mechanism is not clear. Methods: In this study, we investigated the possible mechanism by the strategy of combining network pharmacology analysis with experiment (in vitro and in vivo). First, four kinds of breast cancer cell lines were used to conduct proliferation, apoptosis and cell cycle analysis. Secondly, to study pathophysiological processes of breast cancer at the molecular network level, we for the first time constructed an “integrated apoptosis module network of breast cancer” by assembling the regulatory relationships of canonical apoptosis signaling pathways. Through the strategy of combining network analysis and experiments, we analyzed the main mechanism of RJSJ in breast cancer and screened out the core genes. We further studied the inhibitory effect of RJSJ combined with carboplatin (CBP) in vivo. Finally, the synergistic effect of RJSJ and CBP were analyzed and the potential active components in RJSJ were predicted.Results: This study demonstrated that RJSJ could significantly inhibit breast cancer cell proliferation and induce apoptosis in a concentration-dependent manner. The primary mechanism of RJSJ in the treatment of breast cancer was pro-apoptotic. The core apoptosis genes regulated by RJSJ were cIAP1/2 and XIAP. We also found that RJSJ in combination with CBP tended to synergistically induce apoptosis, which might mainly be achieved through the regulation of multiple targets and pathways. Alexandrin (BX05, XKC02, SCG01), baicalin (BX22), guanosine (BX32), arjunglucoside I (XKC10) etc. were predicted as potential active components.Conclusions: These findings provide the rationale for exploring the therapeutic effects of RJSJ against breast cancer and providing a bridge for the combined use of Chinese and Western medicine.

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Section: Effect Of Rjsj On the Cell Cycle Distribution In Breast Cancmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Ruanjian Sanjie Decoction Induces Apoptosis in Triple-negative Breast Cancer Cells by Downregulating cIAP1/2 and XIAP

Zhao¹,

Wang²,

Jia³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…For example, overexpression of XIAP leads to poor survival and prognosis of breast cancer, esophageal cancer, gastrointestinal cancer, etc. [250][251][252][253][254] In addition, overexpression of XIAP leads to chemoresistance in different cancer types such as colorectal cancer, hepatocellular carcinoma, gastric cancer, glioblastoma, leukemia, ovarian cancer, and its inhibition leads to the sensitization of cancer cells to different chemotherapeutic agents. [255][256][257][258][259][260][261] Moreover, it has been well established that enhanced expression of XIAP leads to radioresistance in many types such as esophageal cancer, glioblastoma, laryngeal carcinoma, and rectal adenocarcinoma, and suppression of this protein sensitizes the cancer cells to radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases

Daimary

Girisa

Dey

et al. 2021

J Biochem & Molecular Tox

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Chronic diseases are a serious health concern worldwide, especially in the elderly population. Most chronic diseases like cancer, cardiovascular ailments, neurodegenerative disorders, and autoimmune diseases are caused due to the abnormal functioning of multiple signaling pathways that give rise to critical anomalies in the body. Although a lot of advanced therapies are available, these have failed to entirely cure the disease due to their less efficacy. Apart from this, they have been shown to manifest disturbing side effects which hamper the patient's quality of life to the extreme. Since the last few decades, extensive studies have been done on natural herbs due to their excellent medicinal benefits. Components present in natural herbs target multiple signaling pathways involved in diseases and therefore hold high potential in the prevention and treatment of various chronic diseases. Embelin, a benzoquinone, is one such agent isolated from Embelia ribes, which has shown excellent biological activities toward several chronic ailments by upregulating a number of antioxidant enzymes (e.g.

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“…A whole family of apoptosis inhibitor proteins (IAPs) is known, among which IAP is a potent inhibitor of caspases [ 81 ]. Many studies show increased IAP expression in various types of cancer, such as cancers of the lung [ 82 ], prostate [ 83 ], chest [ 84 ], bile [ 85 ], ovaries [ 86 ], and bladder [ 87 ], as well as melanoma [ 88 ], lymphoma [ 89 ], glioblastoma [ 90 ], and hepatocellular carcinoma [ 91 ]. It is noted that the overexpression of XIAP promotes the survival of cancer cells and the development of cancer [ 92 ]; however, mitochondria, in this case, may have a protective function.…”

Section: The Role Of Mitochondria In Oncogenesis and Tumor Developmentmentioning

confidence: 99%

The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer

et al. 2022

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MicroRNAs are short, non-coding RNA molecules regulating gene expression by inhibiting the translation of messenger RNA (mRNA) or leading to degradation. The miRNAs are encoded in the nuclear genome and exported to the cytosol. However, miRNAs have been found in mitochondria and are probably derived from mitochondrial DNA. These miRNAs are able to directly regulate mitochondrial genes and mitochondrial activity. Mitochondrial dysfunction is the cause of many diseases, including cancer. In this review, we consider the role of mitochondrial miRNAs in the pathogenesis of lung cancer with particular reference to radon exposure.

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Expression of nuclear XIAP associates with cell growth and drug resistance and confers poor prognosis in breast cancer

Cited by 16 publications

References 29 publications

Ruanjian Sanjie Decoction Induces Apoptosis in Triple-negative Breast Cancer Cells by Downregulating cIAP1/2 and XIAP

Ruanjian Sanjie Decoction Induces Apoptosis in Triple-negative Breast Cancer Cells by Downregulating cIAP1/2 and XIAP

Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases

The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer

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