Expression of p53 protein related to human papillomavirus and DNA ploidy in superficial esophageal carcinoma

Nakamura, Tsutomu; Ide, Hiroko; Eguchi, Reiki; Hayashi, Kazuhiko; Hanyu, Fujio; Nagasako, Kou; Yukawa, Masahiko; Asaka, Kazuyuki; Fujimori, Takahiro; Maeda, Sakan

doi:10.1007/bf00311431

Cited by 16 publications

(5 citation statements)

References 28 publications

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“…In addition, we noticed that the survival of patients depended mainly on the types of operations performed. This parameter was not taken into considerations in previous investigations (Chanvitan et al, 1995;Furihata et al, 1993;Goukon et al, 1994;Maesawa et al, 1994;Nakamura et al, 1995;Sarbia et al, 1994;Shimaya et al, 1993;Vijeyasingam et al, 1994;Wang et al, 1994). We thus conclude that p53 mutations might play a role in predicting the survival of patients with oesophageal squamous cell carcinomas, although the types of operation (curative vs. palliative) performed have a more important impact on clinical decision making.…”

Section: Discussionmentioning

confidence: 61%

“…Investigations pertaining to p53 aberrations in predicting prognosis of patients with the oesophageal cancers reveal conflicting results (Chanvitan et al, 1995;Furihata et al, 1993;Goukon et al, 1994;Maesawa et al, 1994;Nakamura et al, 1995;Sarbia et al, 1994;Shimaya et al, 1993;Vijeyasingam et al, 1994;Wang et al, 1994). We believe that these discrepancies can not be explained solely by genetic and etiologic factors which affect different ethnic groups.…”

Section: Discussionmentioning

confidence: 89%

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Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: A prospective clinico‐pathological study and survival analysis of 70 patients

Lam¹,

Tsao²,

Zhang³

et al. 1997

Int. J. Cancer

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The tissues from 70 Chinese patients with oesophageal squamous cell carcinoma were prospectively collected to study for the pattern of p53 mutations and its relationship with clinico-pathological features and prognosis using immunohistochemistry, polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis and DNA sequencing. p53 over-expression and p53 mutations were detected in 73% and 44% of the patients. These p53 aberrations had no relationship with the patient age, sex, smoking/ drinking habits and tumor site, size or stage. The p53 over-expression was more intense in moderately/poorlydifferentiated squamous cell carcinomas. Thirty-three p53 mutations were noted in 31 patients; 18.2% in exon 5, 15.2% in exon 6, 33.3% in exon 7 and 33.3% in exon 8. Mutations were primarily point mutations and common in codons 248, 273 and 285. There were 46% transversions, 36% transitions and 18% frameshift. The survival of the patients depended mainly on the extent of resection. In patients with stage III oesophageal cancer, the median survival of those with p53 mutations was 6.8 months whereas those without was 12. Oesophageal squamous cell carcinoma is one of the most common human cancers world-wide (Parkin et al., 1988). The incidence and mortality rate is particularly high among Chinese populations, i.e., in Hong Kong (Lee, 1991). Despite various therapeutic interventions, including surgery, radiotherapy, and chemotherapy, the 5-year survival rate for this disease remains low (Law et al., 1992). Thus, to improve therapeutic and preventive interventions, a biological understanding of the nature of the disease is essential.The p53 gene coding for a 53-kDa nuclear phosphoprotein is believed to be a tumour suppressor gene. It is located on the short-arm of chromosome 17 and is a critical regulator of cell growth, differentiation and apoptosis through its actions in cellcycle checkpoint control (Greenblatt et al., 1994). It is also well known that mutation of the p53 gene is the most common genetic alteration in human cancers. A number of studies have shown that p53 protein over-expression may provide insight into the carcinogenesis in oesophageal squamous cell carcinomas (Lam et al., 1995b). However, there is lack of well planned molecular studies to correlate p53 mutations with the clinico-pathological parameters (including the survival data) in patients with oesophageal squamous cell carcinomas.In this study, we have analysed the correlation of p53 gene mutations with the clinico-pathological features. The profile of p53 mutations was also studied by DNA sequencing in order to gain insight on the carcinogenesis of oesophageal squamous cell carcinomas in Hong Kong Chinese. MATERIAL AND METHODS Patient characteristicsThe patients who were chosen for our study had resections for oesophageal cancers at some point during the period between July 1990 and June 1994 at Queen Mary Hospital. The selection criteria for this study included primary oesophageal squamous cell carcinomas from Chinese patients;...

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 89%

Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: A prospective clinico‐pathological study and survival analysis of 70 patients

Lam¹,

Tsao²,

Zhang³

et al. 1997

Int. J. Cancer

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“…In total, 9649 oesophageal cancer patients were evaluated in all of the 76 included studies (Table S2). There were 67 studies and 5 studies specifically addressed oesophageal SCC and adenocarcinoma. Among the studies addressing oesophageal SCC, 46 were conducted in Asians, 19 in Europeans and Americans, 2 in Africans.…”

Section: Resultsmentioning

confidence: 99%

Systematic review with meta‐analysis: the association between human papillomavirus infection and oesophageal cancer

Gao

et al. 2013

Aliment Pharmacol Ther

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“…The results of studies vary even though the same methods are used because there are differences in detection criteria. For example, there are differences in the cut-off values of IHC staining [Hille et al, 1986;Mori et al, 1989;Nakamura et al, 1995] or in serum ELISA [Mork et al, 2001;Smith et al, 2008], in PCR primers [Cattani et al, 1998;van Houten et al, 2001;Koskinen et al, 2003], and in the probes used for HPV in ISH [Chang et al, 1990;Kulski et al, 1990;Benamouzig et al, 1992]. In addition, the results can vary because the sensitivity and specificity of screening methods can differ in the same study [Mellin Dahlstrand et al, 2005;Smeets et al, 2007;Kuo et al, 2008;Rotnaglova et al, 2010].…”

Section: Discussionmentioning

confidence: 99%

Statistical analysis of human papillomavirus in a subset of upper aerodigestive tract tumors

Liu¹,

Diao³

et al. 2013

J. Med. Virol.

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Human papilloma virus (HPV) has been detected in some upper aerodigestive tract tumors, but the correlation between HPV and these tumors is not well understood. There is also some controversy regarding this correlation because a large variation in the prevalence of HPV in these tumors has been reported. To discuss the impact of HPV infection on upper aerodigestive tract tumors, this review estimated systematically the prevalence and risk of HPV in upper aerodigestive tract tumors from studies published between 1982 and 2012. In total, 418 articles were selected, which included 273 studies on the head and neck and 145 studies on esophageal squamous cell carcinoma. The overall prevalence of HPV in the 5,467 head and neck squamous cell carcinoma specimens was 36.3%. HPV was detected more frequently in the Americas (40%), than in Asia (38.6%), Europe (32%), or others regions (30.5%). The prevalence of HPV was significantly higher in oropharyngeal (48.5%) than in oral (32.5%), laryngeal (30.7%), and unselected head and neck squamous cell carcinoma (33.3%) (P < 0.001). The pooled prevalence of HPV in the 6,912 esophageal squamous cell carcinoma cases was 38.9% and it was significantly higher in China (44%) versus other regions (31.3%) (P < 0.05). Meta-analysis showed that head and neck and esophageal squamous cell carcinoma are associated with HPV infection (combined OR: 3.58, OR for head and neck and esophageal squamous cell carcinoma: 4.20). These findings suggest that HPV might be linked etiologically to the development of some upper aerodigestive tract tumors.

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Expression of p53 protein related to human papillomavirus and DNA ploidy in superficial esophageal carcinoma

Cited by 16 publications

References 28 publications

Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: A prospective clinico‐pathological study and survival analysis of 70 patients

Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: A prospective clinico‐pathological study and survival analysis of 70 patients

Systematic review with meta‐analysis: the association between human papillomavirus infection and oesophageal cancer

Statistical analysis of human papillomavirus in a subset of upper aerodigestive tract tumors

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