2012
DOI: 10.1684/ejd.2011.1575
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Expression of Peroxisome Proliferator Activator Receptor β/δ (PPARβ/δ) in acne vulgaris

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Cited by 12 publications
(6 citation statements)
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“…PPARc and PPARa are expressed in human sebocytes, and their activation by specific ligands has been shown to promote sebocyte lipogenesis, that is, lipid droplet accumulation in immature sebocytes. An increased presence of PPARb/d in the lesional as well as non-lesional skin of patients with acne vulgaris as compared to normal controls too has been observed in a recent study [25]. Activation of PPARa appears to increase differentiation-induced apoptosis, thus, may contribute to follicular comedogenesis.…”
Section: Sebum Productionmentioning
confidence: 65%
See 1 more Smart Citation
“…PPARc and PPARa are expressed in human sebocytes, and their activation by specific ligands has been shown to promote sebocyte lipogenesis, that is, lipid droplet accumulation in immature sebocytes. An increased presence of PPARb/d in the lesional as well as non-lesional skin of patients with acne vulgaris as compared to normal controls too has been observed in a recent study [25]. Activation of PPARa appears to increase differentiation-induced apoptosis, thus, may contribute to follicular comedogenesis.…”
Section: Sebum Productionmentioning
confidence: 65%
“…The two isoforms, PPARa and PPARc, are the ones considered involved in the sebocytes biology. However, Elmongy and Shaker [25] observed significantly higher levels of PPARb/d mRNA in skin of acne patients than controls and in patients' lesional than non-lesional skin without any significant difference between inflammatory and non-inflammatory lesions. Amr et al [2] further confirmed the role of PPARc in the pathogenesis of acne vulgaris by studying the Pro12Ala polymorphism in acne patients, which is associated with reduced transcriptional activity of PPARc, and found its lower rate in patients with acne than that in controls.…”
Section: Acne Vulgarismentioning
confidence: 89%
“…Unsurprisingly, a number of lipid mediators that have been shown to be PPAR ligands impact sebocyte lipid synthesis and metabolism (51) . In fact, increased sebum levels combined with follicular hyperkeratinization are hallmarks of acne vulgaris, and PPAR β / δ was found overexpressed in inflammatory and non-inflammatory acne vulgaris (52) .…”
Section: Acnementioning
confidence: 99%
“…Estos mismos estudios y la comprensión de la similitud existente entre la adipogénesis y la lipogénsis sebácea, llevan a la hipótesis de que los PPAR pueden ser importantes reguladores en la producción de sebo y en el desarrollo del acné 71,78 . Como se mencionó anteriormente, se han demostrado diferentes subtipos de PPAR en la piel 71 ; en el caso de los subtipos de PPAR en el acné, en un estudio reciente se encontró un incremento en la expresión de PPAR β/σ en el acné inflamatorio, en comparación con el no inflamatorio 79 .…”
Section: Receptores Activadores De Proliferación De Peroxisomas En Elunclassified