2000
DOI: 10.1006/jmcc.2000.1120
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Expression of Plasma Membrane Calcium ATPases in Phenotypically Distinct Canine Vascular Smooth Muscle Cells

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Cited by 15 publications
(16 citation statements)
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“…Reciprocally, inhibition of PMCA4a upregulation with Wortmannin inhibited cell proliferation [3]. These results may appear incompatible with the general concept whereby decreased PMCA1 and SERCA2a, increased TRPC channels and IP 3 -mediated Ca 2+ release contribute to the sustained increase in cytoplasmic Ca 2+ levels that are necessary to drive cell proliferation.…”
Section: Role Of Pmcamentioning
confidence: 78%
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“…Reciprocally, inhibition of PMCA4a upregulation with Wortmannin inhibited cell proliferation [3]. These results may appear incompatible with the general concept whereby decreased PMCA1 and SERCA2a, increased TRPC channels and IP 3 -mediated Ca 2+ release contribute to the sustained increase in cytoplasmic Ca 2+ levels that are necessary to drive cell proliferation.…”
Section: Role Of Pmcamentioning
confidence: 78%
“…In fact, 2-APB, at much lower concentrations (30 µM) is a potent inhibitor of SOC channels and is also known to partially inhibit TRPC channels [137], while U-73122 acts upstream to inhibit PLC, and would thus consequently inhibit the activation of receptor-operated channels, including all TRPC channels. Nonetheless, in serum-stimulated VSMC, proliferation is associated with a sustained increase in intracellular Ca 2+ partially due to enhanced excitability of IP 3 R following binding of IP 3 . In addition, a recent report showed a sixfold increase in the expression level of IP 3 R1 as VSMC progressed from G0 to G1/S of the cell cycle [5].…”
Section: Role Of Ip 3 R Ca 2+ Release Channelsmentioning
confidence: 99%
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“…Then, the resulting spontaneous transient outward currents (STOC) hyperpolarize the membrane and decrease the open probability of Ltype Ca 2+ channels [23]. Cytosolic calcium is extruded at the level of plasma membrane by plasma membrane Ca 2+ ATPase (PMCA) and the Na + /Ca 2+ exchanger (NCX) [24,25]. The principal amount of cytosolic Ca 2+ (> 70%) is re-uploaded to the internal store.…”
Section: Calcium Handling By the Plasma Membrane's Calcium Channels Amentioning
confidence: 99%
“…Due to their widespread distribution, they are thought to be important "housekeeping" Ca 2+ -pumps, but their function in smooth muscle is less well known. In addition to Ca 2+ homeostasis, it has been suggested that PMCA is associated with vascular smooth muscle proliferation (Abramowitz et al, 2000) and signal transduction (Hammes et al, 1998). The latter is based on the PDZ domains in PMCA4b which lead to a complex with nitric oxide synthase I in caveolae of vascular smooth muscle (Schuh et al, 2001).…”
Section: Plasma Membrane Ca 2+ Pumpsmentioning
confidence: 99%