Expression of Po66-CBP, a galectin-8, in different types of primary and secondary broncho-pulmonary tumors

Henno, Sébastien; Brichory, Franck; Langanay, Thierry; Desrues, B.; Bidon, Nathalie; Delaval, P.; Mp, Ramée; Dazord, L.; Caulet‐Maugendre, Sylvie

doi:10.3892/or.9.1.177

Cited by 13 publications

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“…The presence of galectin-8 in lung tumor cells and its absence or very low levels in normal lung tissues permits the use of monoclonal antibodies (Po66) for the prevention and treatment of lung cancer. Prior to the knowledge that this antibody was able to specifically bind galectin-8, it was used to detect human lung squamous cell carcinoma by immunoscintigraphy [54,55]. This clinical investigation showed that Po66 antibody was able to detect specifically the lung squamous cell carcinoma recurrence [55].…”

Section: Discussionmentioning

confidence: 99%

Galectins as Cancer Biomarkers

Balan

Nangia‐Makker

Raz

2010

Cancers

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Galectins are a group of proteins that bind β-galactosides through evolutionarily conserved sequence elements of the carbohydrate recognition domain (CRD). Proteins similar to galectins can be found in very primitive animals such as sponges. Each galectin has an individual carbohydrate binding preference and can be found in cytoplasm as well as in the nucleus. They also can be secreted through non-classical pathways and function extra-cellularly. Experimental and clinical data demonstrate a correlation between galectin expression and tumor progression and metastasis, and therefore, galectins have the potential to serve as reliable tumor markers. In this review, we describe the expression and role of galectins in different cancers and their clinical applications for diagnostic use.

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Section: Discussionmentioning

confidence: 99%

Galectins as Cancer Biomarkers

Balan

Nangia‐Makker

Raz

2010

Cancers

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“…Galectin expression is involved not only in myeloid cell differentiation but also in neoplasm biology. Indeed, higher galectin-3 and -8 expressions are frequently associated with poor prognosis [46,47], but higher galectin-9 expression is linked to better prognosis in melanoma patients [34]. Therefore, further study on the molecular mechanisms involved in galectin expressions and functions may open new avenues not only in basic biomedical research but also in disease diagnosis, prognosis, and clinical therapy.…”

Section: Discussionmentioning

confidence: 99%

Potential roles of galectins in myeloid differentiation into three different lineages

Abedin

Kashio

Seki

et al. 2003

Journal of Leukocyte Biology

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Little is known about the roles of galectins, a family of beta-galactoside-binding lectins, in myeloid cell differentiation. In the present experiments, we used HL-60 cells as a model of myeloid cell differentiation. The HL-60 cells were differentiated into eosinophil-, monocyte-, and neutrophil-like cells by coculture with sodium butyrate under a mild alkaline condition, phorbol 12-myristate 13-acetate, and dimethyl sulfoxide, respectively. Thus, the expression of galectins in HL-60 cells during differentiation into three different lineages was assessed. Reverse transcriptase-polymerase chain reaction analyses revealed that undifferentiated HL-60 cells expressed galectin-1, -3, -8, -9, and -10 (identical to Charcot Leyden crystal) mRNAs, and galectin-2, -4, and -7 were negligible before and after the differentiations. We failed to detect evident changes in the mRNA levels of galectin-1 and -8 during the differentiations. However, during the eosinophilic differentiation, galectin-9 mRNA expression was gradually decreased, whereas galectin-10 mRNA expression was increased. During the course of monocytic differentiation, galectin-9 mRNA expression was down-regulated, whereas galectin-3 mRNA expression was up-regulated. Moreover, only galectin-10 mRNA expression was enhanced in the process of neutrophilic differentiation. These changes in galectin expressions were confirmed by Western blot and flow cytometry analyses. It is thus suggested that changes in the expressions of galectin-3, -9, and -10 are potentially important for myeloid cell differentiation into specific lineages.

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“…An immunohistochemical staining study was previously conducted on the primary and secondary lung cancers of various histologic types (29, 30). Henno et al (29) found that galectin-8 was strongly expressed in squamous cell carcinoma of the lung, but it was weakly expressed in adenocarcinoma and it was not revealed at all in small-cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Henno et al (29) found that galectin-8 was strongly expressed in squamous cell carcinoma of the lung, but it was weakly expressed in adenocarcinoma and it was not revealed at all in small-cell carcinoma. By observing the relations between the expression of galectin-8 and the differentiation of squamous cell carcinoma and neuroendocrine tumor, they insisted that the expression of galectin-8 was related with the type of a tumor.…”

Section: Discussionmentioning

confidence: 99%

Galectin-8 Expression in Laryngeal Squamous Cell Carcinoma

Dong

Kim

Park

et al. 2009

Clin Exp Otorhinolaryngol

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ObjectivesDespite the ongoing development of treatment protocols for laryngeal squamous cell carcinoma (LSCC), the patients suffering with this malady have shown only a modestly improved outcome. This poor outcome has been attributed to the lack of therapy that's individualized to the tumor's biological properties. Various studies have showed that galectin-8 is widely expressed in tumor tissues as well as in normal tissues, and the level of the galectin-8 expression may correlate with the malignancy of human squamous cell carcinoma. The purpose of this study is to evaluate the expression of galectin-8 and to investigate its correlations with the primary stage, the nodal involvement, the clinical stage and the histologic grade of squamous cell carcinoma of the larynx.MethodsThe paraffin-embedded tissue specimens from 77 patients who were diagnosed as LSCC between 1993 and 2007 were immunohistochemically stained for galectin-8.ResultsImmunohistochemical analysis showed that a strong positive expression of galectin-8 was correlated with the T-stages, the nodal stages and the clinical stages. However, the histopathologic grades were not correlated with the galectin-8 expression in LSCC.ConclusionThe expression of galectin-8 protein can be used as a prognostic factor for patients with LSCC.

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Expression of Po66-CBP, a galectin-8, in different types of primary and secondary broncho-pulmonary tumors

Cited by 13 publications

References 0 publications

Galectins as Cancer Biomarkers

Galectins as Cancer Biomarkers

Potential roles of galectins in myeloid differentiation into three different lineages

Galectin-8 Expression in Laryngeal Squamous Cell Carcinoma

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