Expression of praxis induction on cortical excitability in juvenile myoclonic epilepsy

Vidal-Dourado, Marcos; Nunes, Karlo Faria; Guaranha, Mirian Salvadori Bittar; Giuliano, Lydia Maria Pereira; Yacubian, Elza Márcia Targas; Manzano, Gilberto Mastrocola

doi:10.1016/j.clinph.2016.03.028

Cited by 6 publications

(3 citation statements)

References 47 publications

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“…However, some recent studies using quantitative EEG (qEEG) analysis reported abnormal changes in background activity in JME patients [ 5 – 7 ]. In addition, neuropsychological studies showed cognitive dysfunction [ 8 – 10 ], and several studies using multimodal methods such as magnetoencephalography (MEG), functional magnetic resonance imaging (fMRI), and evoked potentials have supported these abnormalities in JME [ 11 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of background EEG activity in juvenile myoclonic epilepsy during valproic acid treatment: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study

et al. 2022

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Background By definition, the background EEG is normal in juvenile myoclonic epilepsy (JME) patients and not accompanied by other developmental and cognitive problems. However, some recent studies using quantitative EEG (qEEG) reported abnormal changes in the background activity. QEEG investigation in patients undergoing anticonvulsant treatment might be a useful approach to explore the electrophysiology and anticonvulsant effects in JME. Methods We investigated background EEG activity changes in patients undergoing valproic acid (VPA) treatment using qEEG analysis in a distributed source model. In 17 children with JME, non-parametric statistical analysis using standardized low-resolution brain electromagnetic tomography was performed to compare the current density distribution of four frequency bands (delta, theta, alpha, and beta) between untreated and treated conditions. Results VPA reduced background EEG activity in the low-frequency (delta-theta) bands across the frontal, parieto-occipital, and limbic lobes (threshold log-F-ratio = ±1.414, p < 0.05; threshold log-F-ratio= ±1.465, p < 0.01). In the delta band, comparative analysis revealed significant current density differences in the occipital, parietal, and limbic lobes. In the theta band, the analysis revealed significant differences in the frontal, occipital, and limbic lobes. The maximal difference was found in the delta band in the cuneus of the left occipital lobe (log-F-ratio = −1.840) and the theta band in the medial frontal gyrus of the left frontal lobe (log-F-ratio = −1.610). Conclusions This study demonstrated the anticonvulsant effects on the neural networks involved in JME. In addition, these findings suggested the focal features and the possibility of functional deficits in patients with JME.

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Section: Introductionmentioning

confidence: 99%

Comparative analysis of background EEG activity in juvenile myoclonic epilepsy during valproic acid treatment: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study

et al. 2022

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“…[ 25 , 27 , 28 ] These results were supported in several functional studies using EEG, fMRI, and evoked potentials. [ 29 – 31 ] In addition, the distribution of the temporal cortex and subcortical structures, such as thalamus and cerebellum, has been reported. [ 5 , 13 , 25 ]…”

Section: Discussionmentioning

confidence: 99%

“…[25,27,28] These results were supported in several functional studies using EEG, fMRI, and evoked potentials. [29][30][31] In addition, the distribution of the temporal cortex and subcortical structures, such as thalamus and cerebellum, has been reported. [5,13,25] In our study, source localization of epileptiform discharges was distributed in various regions including the parietal and occipital lobes over the frontal lobe.…”

Section: Discussionmentioning

confidence: 99%

Distributed source localization of epileptiform discharges in juvenile myoclonic epilepsy: Standardized low-resolution brain electromagnetic tomography (sLORETA) Study

et al. 2022

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Juvenile myoclonic epilepsy (JME) is a common generalized epilepsy syndrome considered the prototype of idiopathic generalized epilepsy. To date, generalized and focal seizures have been the fundamental concepts for classifying seizure types. In several studies, focal features of JME have been reported predominantly in the frontal lobe. However, results in previous studies are inconsistent. Therefore, we investigated the origin of epileptiform discharges in JME. We performed electroencephalography source localization using a distributed model with standardized low-resolution brain electromagnetic tomography. In 20 patients with JME, standardized low-resolution brain electromagnetic tomography images corresponding to the midpoint of the ascending phase and the negative peak of epileptiform discharges were obtained from a total of 362 electroencephalography epochs (181 epochs at each timepoint). At the ascending phase, the maximal current source density was located in the frontal lobe (58.6%), followed by the parietal (26.5%) and occipital lobes (8.8%). At the negative peak, the maximal current source density was located in the frontal lobe (69.1%), followed by the parietal (11.6%) and occipital lobes (9.4%). In the ascending phase, 41.4% of discharges were located outside the frontal lobe, and 30.9% were in the negative peak. Frontal predominance of epileptiform discharges was observed; however, source localization extending to various cortical regions also was identified. This widespread pattern was more prominent in the ascending phase ( P = .038). The study results showed that JME includes widespread cortical regions over the frontal lobe. The current concept of generalized epilepsy and pathophysiology in JME needs further validation.

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Recovery function of somatosensory evoked potentials in juvenile myoclonic epilepsy*

Kızıltan¹,

Yenı²,

Alış³

et al. 2019

Somatosensory & Motor Research

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Expression of praxis induction on cortical excitability in juvenile myoclonic epilepsy

Cited by 6 publications

References 47 publications

Comparative analysis of background EEG activity in juvenile myoclonic epilepsy during valproic acid treatment: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study

Comparative analysis of background EEG activity in juvenile myoclonic epilepsy during valproic acid treatment: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study

Distributed source localization of epileptiform discharges in juvenile myoclonic epilepsy: Standardized low-resolution brain electromagnetic tomography (sLORETA) Study

Recovery function of somatosensory evoked potentials in juvenile myoclonic epilepsy*

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