Expression of programmed cell death ligand‑1 protein in germinal center B‑cell‑like and non‑germinal center B‑cell‑like subtypes of diffuse large B‑cell lymphoma

Asrini, Rizka; Ham, Maria Francisca; Asmarinah, Asmarinah; Harahap, Agnes Stephanie; Hardjolukito, Endang

doi:10.3892/mco.2021.2474

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…However, a previous study demonstrated that PD-1 is especially expressed by germinal centre-associated T cells in reactive lymphoid tissue [21,37]. In addition, PD-L1 in the tumour cells is suggested to be more highly expressed in non-GCB type than GCB-type [38]. Because lymph2Cx has allowed for digital gene expression profile (GEP) on tissue and has shown a greater concordance with GEP than IHC, such platforms should be applied in further studies [39].…”

Section: Discussionmentioning

confidence: 99%

PD‐1 expression on tumour‐infiltrating cells is a prognostic factor for relapsed or refractory diffuse large B‐cell lymphoma

Wada,

Kamijo,

Shimomura

et al. 2023

Immunology

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BackgroundThe tumour microenvironment (TME), which is modulated after immune‐chemotherapy, is involved in tumour growth and metastasis. Programmed cell death 1 (PD‐1) expressed on tumour‐infiltrating non‐malignant cells plays an important role in the TME through the PD‐1/programmed cell death ligand 1 (PD‐L1) signalling pathway. However, its impact in patients with relapsed or refractory (R/R) diffuse large B‐cell lymphoma (DLBCL) remains unclear.MethodsWe conducted a retrospective study using tissue samples at relapse for patients with R/R DLBCL (n = 45) and evaluated the clinical impact of PD‐1 expression on tumour‐infiltrating non‐malignant cells (microenvironmental PD‐1, mPD‐1). In addition, corresponding 27 samples at diagnosis were analysed to evaluate the changes in PD‐1/PD‐L1 expression in the TME after chemotherapy.ResultsPatients with mPD‐1+ DLBCL showed significantly better overall survival compared with patients with mPD‐1− DLBCL (hazard ratio, 0.30, p = 0.03). Among patients with mPD‐1− DLBCL, those positive for neoplastic or microenvironmental PD‐L1 (nPD‐L1+ or mPD‐L1+) showed significantly worse outcomes. Microenvironmental PD‐1 and PD‐L1 expression has high correlation at relapse, although none was found at diagnosis.ConclusionWe determined the clinical impact of microenvironmental PD‐1 expression and its relationship with neoplastic or microenvironmental expression of PD‐L1 in patients with R/R DLBCL. The expression of PD‐1 and PD‐L1 in the TME dramatically changes during the chemotherapy. Therefore, evaluating TME at relapse, not at diagnosis is useful to predict the outcomes of R/R DLBCL patients.

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