Expression of receptor activator of nuclear factor kappa B ligand relates to inflammatory bone resorption, with or without occlusal trauma, in rats

Yoshinaga, Y.; Ukai, Takashi; Abe, Yoshihiro; Hara, Yoshitaka

doi:10.1111/j.1600-0765.2007.00960.x

Cited by 56 publications

(64 citation statements)

References 42 publications

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“…In our study, the trauma groups exhibited hyaline degeneration of periodontal ligament tissue and alveolar bone resorption in the furcation area with the appearance of osteoclast like cells. These findings correspond precisely to our earlier study .…”

Section: Discussionsupporting

confidence: 93%

“…For excessive occlusal loading to the maxillary right first molar , the occlusal surface of the mandibular right first molar was raised by placing a metal wire (1.0 mm in diameter) bonded with resin cements (Super‐Bond C&B; Sun Medical, Shiga, Japan), as an occlusal interference, under general anesthesia with sodium pentobarbital at 25 mg/kg of body weight, 1 d after the booster injection, in the T group, the T+I group and the n−(T+I) group. For the induction of experimental periodontitis , the I group, the T+I group and the n−(T+I) group received (under general anesthesia with isoflurane) daily topical applications of E. coli LPS in PBS (50 μg/μL) on the palatal gingival sulcus of the maxillary right first molar using a micropipette just after the wire was placed on the mandibular first molar on the day after the booster injection.…”

Section: Methodsmentioning

confidence: 99%

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Occlusal trauma accelerates attachment loss at the onset of experimental periodontitis in rats

Nakatsu

Yoshinaga

Kuramoto

et al. 2013

J of Periodontal Research

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When inflammation was combined with occlusal trauma, immune complexes were confirmed in more expanding areas than in the area of the I group without occlusal trauma, and loss of attachment at the onset of experimental periodontitis was increased. Damage of collagen fibers by occlusal trauma may elevate the permeability of the antigen through the tissue and result in expansion of the area of immune-complex formation and accelerating inflammatory reaction. The periodontal tissue destruction was thus greater in the T+I group than in the I group.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Occlusal trauma accelerates attachment loss at the onset of experimental periodontitis in rats

Nakatsu

Yoshinaga

Kuramoto

et al. 2013

J of Periodontal Research

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“…*** P < 0.001. (Yoshinaga et al 2007), was evident in the PDL region of Bsp -/mice, although inflammatory cells were not observed (Foster et al 2013). Furthermore, loss of PDL attachment and epithelial downgrowth in Bsp -/mice compromise the shock-absorbing function of the PDL, disturbing the stress distribution function of the periodontium and subjecting the bony socket to increased and possibly traumatic compression forces during mastication.…”

Section: Role Of Altered Mechanotransduction In Bsp -/-Mice Periodontmentioning

confidence: 96%

Mechanical Forces Exacerbate Periodontal Defects in Bsp-null Mice

et al. 2015

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Bone sialoprotein (BSP) is an acidic phosphoprotein with collagen-binding, cell attachment, and hydroxyapatite-nucleating properties. BSP expression in mineralized tissues is upregulated at onset of mineralization. Bsp-null (Bsp(-/-)) mice exhibit reductions in bone mineral density, bone turnover, osteoclast activation, and impaired bone healing. Furthermore, Bsp(-/-) mice have marked periodontal tissue breakdown, with a lack of acellular cementum leading to periodontal ligament detachment, extensive alveolar bone and tooth root resorption, and incisor malocclusion. We hypothesized that altered mechanical stress from mastication contributes to periodontal destruction observed in Bsp(-/-) mice. This hypothesis was tested by comparing Bsp(-/-) and wild-type mice fed with standard hard pellet diet or soft powder diet. Dentoalveolar tissues were analyzed using histology and micro-computed tomography. By 8 wk of age, Bsp(-/-) mice exhibited molar and incisor malocclusion regardless of diet. Bsp(-/-) mice with hard pellet diet exhibited high incidence (30%) of severe incisor malocclusion, 10% lower body weight, 3% reduced femur length, and 30% elevated serum alkaline phosphatase activity compared to wild type. Soft powder diet reduced severe incisor malocclusion incidence to 3% in Bsp(-/-) mice, supporting the hypothesis that occlusal loading contributed to the malocclusion phenotype. Furthermore, Bsp(-/-) mice in the soft powder diet group featured normal body weight, long bone length, and serum alkaline phosphatase activity, suggesting that tooth dysfunction and malnutrition contribute to growth and skeletal defects reported in Bsp(-/-) mice. Bsp(-/-) incisors also erupt at a slower rate, which likely leads to the observed thickened dentin and enhanced mineralization of dentin and enamel toward the apical end. We propose that the decrease in eruption rate is due to a lack of acellular cementum and associated defective periodontal attachment. These data demonstrate the importance of BSP in maintaining proper periodontal function and alveolar bone remodeling and point to dental dysfunction as causative factor of skeletal defects observed in Bsp(-/-) mice.

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“…However, this study shows that bone resorption occurs along the full extent of the tooth root, as well as in the centre of the alveolar septum. It also increases the activity of osteoclasts [23][24][25] involved in inflammatory bone resorption, 51 maintaining the latter as an active process until 21 days post-trauma, thus delaying the recovery of the PDL width following subluxation. [47][48][49] Thus, subluxation may induce bone resorption because of its capacity to provoke TO through the minor extrusion of the tooth caused by the trauma.…”

Section: Discussionmentioning

confidence: 99%

The influence of traumatic occlusion on the repair process for teeth following subluxation

Amaral

Poi

Debortoli

et al. 2017

Dental Traumatology

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Expression of receptor activator of nuclear factor kappa B ligand relates to inflammatory bone resorption, with or without occlusal trauma, in rats

Cited by 56 publications

References 42 publications

Occlusal trauma accelerates attachment loss at the onset of experimental periodontitis in rats

Occlusal trauma accelerates attachment loss at the onset of experimental periodontitis in rats

Mechanical Forces Exacerbate Periodontal Defects in Bsp-null Mice

The influence of traumatic occlusion on the repair process for teeth following subluxation

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