Expression of renal vitamin D receptors and metabolizing enzymes in IgA nephropathy

Arapović, Adela; Vukojević, Katarina; Durdov, Merica Glavina; Benzon, Benjamin; Šolić, Ivana; Racetin, Anita; Jurić, Marija; Čujić, Tanja; Kosović, Ivona; Lozić, Mirela; Škaro, Dijana Borić; Ljutić, Dragan; Saraga-Babić, Mirna; Majce, Ana Simičić; Saraga, Marijan; Filipović, Natalija

doi:10.1016/j.acthis.2021.151740

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Another particularly intriguing study in the realm of IgA nephropathy revealed differential expressions of VDR and the calcitriol-synthesizing enzyme, 1alpha-OHase ( Arapović et al, 2021 ). Patients showed elevated VDR expression in distal tubular cells, contrasted with a marked decrease in 1alpha-OHase ( Arapović et al, 2021 ). This disparity opens new avenues for understanding the disease’s molecular underpinnings and, possibly, its management.…”

Section: Vdr and Human Diseasesmentioning

confidence: 99%

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Yao,

Oduro,

Akintibu

et al. 2024

Front. Pharmacol.

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The Vitamin D receptor (VDR) is a crucial nuclear receptor that plays a vital role in various physiological functions. To a larger extent, the genomic effects of VDR maintain general wellbeing, and its modulation holds implications for multiple diseases. Current evidence regarding using vitamin D or its synthetic analogs to treat non-communicable diseases is insufficient, though observational studies suggest potential benefits. Traditional Chinese medicines (TCMs) and bioactive compounds derived from natural sources have garnered increasing attention. Interestingly, TCM formulae and TCM-derived bioactive compounds have shown promise in modulating VDR activities. This review explores the intriguing potential of TCM and bioactive compounds in modulating VDR activity. We first emphasize the latest information on the genetic expression, function, and structure of VDR, providing a comprehensive understanding of this crucial receptor. Following this, we review several TCM formulae and herbs known to influence VDR alongside the mechanisms underpinning their action. Similarly, we also discuss TCM-based bioactive compounds that target VDR, offering insights into their roles and modes of action.

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Section: Vdr and Human Diseasesmentioning

confidence: 99%

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Yao,

Oduro,

Akintibu

et al. 2024

Front. Pharmacol.

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“…Plazmafereza, kao metoda liječenja može se primijeniti kada kreatinin naglo poraste iznad 500 18 . studije ukazuju na imunomodulatorno djelovanje i antiproteinurični učinak vitamina D dovodeći do usporavanja napredovanja bubrežnog oštećenja 19,20 . Neke studije navode učinkovitost različitih inhibitora komplementa u liječenju IgAN 21 .…”

Section: Summary Introductionunclassified

IgA nephropathy – new insights into IgA nephropathy

2022

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IgA nefropatija je najčešći oblik primarnog glomerulonefritisa u svijetu i značajno doprinosi nastanku kronične bolesti bubrega i završnog stadija bubrežnog zatajenja. Cilj: Prikazati nove spoznaje o IgA nefropatiji. Metode: Napravljen je pregled objavljene literature. Rezultati: Pojavnost IgA nefropatije među zemljama u svijetu je različita, dijelom je povezana s neujednačenim indikacijama za biopsiju bubrega u različitim centrima. Na učestalost IgA nefropatije utječu genetski i okolišni čimbenici. Spektar kliničkih manifestacija bolesti je širok, najčešća je hematurija. Patogeneza još uvijek nije u potpunosti jasna. Dijagnoza je zasnovana isključivo na patohistološkom imunofluoroscentnom nalazu dominantnih galaktoza-deficijentnih IgA1 depozita u mezangiju bubrega. Oksfordska klasifikacija boduje pet patohistoloških značajki IgA nefropatije kao neovisne prediktore rizika za progresiju bubrežne bolesti. Na aktivne lezije moguće je terapijski djelovati. Bolest se liječi neimunosupresivnim i imunosupresivnim lijekovima. Terapijski cilj u djece je smanjiti proteinuriju ispod 0,2 g/dan/1,73 m2 (ili <0,2 g/g kreatinina) i vrijednost krvnog tlaka održavati ispod 50. percentile za dob, spol i tjelesnu visinu. 15-20 godina nakon pojave bolesti, u 20-30% djece razvije se progresivna bolest. Starija dob, hipertenzija, proteinurija i oštećena bubrežna funkcija u času postavljanja dijagnoze loši su prognostički pokazatelji. 20-40% bolesnika razvije krajnji stadija bubrežnog zatajenja unutar 20 godina od dijagnoze. U 40 -60% oboljelih nakon transplantacije bubrega javlja se povratak IgA nefropatije u transplantat. Zaključak: Iako se razumijevanje patogeneze IgA nefropatije značajno proširilo od 1968. godine kada je bolest prvi put opisana, IgA nefropatija je još uvijek čest uzrok nastanka završnog stadija bubrežnog zatajenja. Potrebno je bolje razumijevanje svih čimbenika koji sudjeluju u patogenezi bolesti kako bi se omogućio razvoj učinkovitije terapije.

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Lambda cyhalothrin and chlorantraniliprole caused biochemical, histological, and immunohistochemical alterations in male rabbit liver: Ameliorative effect of vitamins A, D, E, C mixture

et al. 2023

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Expression of renal vitamin D receptors and metabolizing enzymes in IgA nephropathy

Cited by 3 publications

References 40 publications

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

IgA nephropathy – new insights into IgA nephropathy

Lambda cyhalothrin and chlorantraniliprole caused biochemical, histological, and immunohistochemical alterations in male rabbit liver: Ameliorative effect of vitamins A, D, E, C mixture

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