Expression of resistin in the liver of patients with non-alcoholic fatty liver disease

Gierej, Piotr; Gierej, Beata; Kalinowski, Piotr; Wróblewski, Tadeusz; Paluszkiewicz, Rafał; Kobryń, Konrad; Ziarkiewicz‐Wróblewska, Bogna

doi:10.5114/pjp.2017.67583

Cited by 15 publications

(12 citation statements)

References 22 publications

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“…Furthermore, there is some evidence that Kupffer cells and infiltrating macrophages in steatotic livers might also contribute to the whole body production of the adipokine resistin and thereby enhance hepatic insulin resistance [ 148 ].…”

Section: Role Of Macrophages In the Development Of Insulin Resistance...mentioning

confidence: 99%

Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia: A Mutual Ambiguous Relationship in the Development of Metabolic Diseases

Püschel

Klauder

Henkel

2022

JCM

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Metabolic derangement with poor glycemic control accompanying overweight and obesity is associated with chronic low-grade inflammation and hyperinsulinemia. Macrophages, which present a very heterogeneous population of cells, play a key role in the maintenance of normal tissue homeostasis, but functional alterations in the resident macrophage pool as well as newly recruited monocyte-derived macrophages are important drivers in the development of low-grade inflammation. While metabolic dysfunction, insulin resistance and tissue damage may trigger or advance pro-inflammatory responses in macrophages, the inflammation itself contributes to the development of insulin resistance and the resulting hyperinsulinemia. Macrophages express insulin receptors whose downstream signaling networks share a number of knots with the signaling pathways of pattern recognition and cytokine receptors, which shape macrophage polarity. The shared knots allow insulin to enhance or attenuate both pro-inflammatory and anti-inflammatory macrophage responses. This supposedly physiological function may be impaired by hyperinsulinemia or insulin resistance in macrophages. This review discusses the mutual ambiguous relationship of low-grade inflammation, insulin resistance, hyperinsulinemia and the insulin-dependent modulation of macrophage activity with a focus on adipose tissue and liver.

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Section: Role Of Macrophages In the Development Of Insulin Resistance...mentioning

confidence: 99%

Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia: A Mutual Ambiguous Relationship in the Development of Metabolic Diseases

Püschel

Klauder

Henkel

2022

JCM

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“…Resistin expression was increased in subjects with central obesity, T2D and NAFLD (19, 20). Although studies in animal models consistently show that resistin promotes insulin resistance, evidence for this effect in humans is unclear.…”

Section: Resistinmentioning

confidence: 99%

Cytokines and Abnormal Glucose and Lipid Metabolism

et al. 2019

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Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory cytokines, myokines, and osteokines, contribute substantially to the development of abnormal glucose and lipid metabolism. Some cytokines play a positive role in metabolism action, while others have a negative metabolic role linking to the induction of metabolic dysfunction. The mechanisms involved are not fully understood, but are associated with lipid accumulation in organs and tissues, especially in the adipose and liver tissue, changes in energy metabolism, and inflammatory signals derived from various cell types, including immune cells. In this review, we describe the roles of certain cytokines in the regulation of metabolism and inter-organ signaling in regard to the pathophysiological aspects. Given the disease-related changes in circulating levels of relevant cytokines, these factors may serve as biomarkers for the early detection of metabolic disorders. Moreover, based on preclinical studies, certain cytokines that can induce improvements in glucose and lipid metabolism and immune response may emerge as novel targets of broader and more efficacious treatments and prevention of metabolic disease.

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“…In another study by Tsochatzis [41] the level of resistin was found to be related to the severity of fibrosis. In the study conducted by Pagano [59] the level of resistin was found higher in patients with NAFLD compared to the control group, and a positive correlation with inflammation was found.…”

Section: Discussionmentioning

confidence: 85%

Investigation of Adiponectin, Leptin, Retinol Binding Protein-4 and Resistin Levels in Non-Diabetic and Non-Obese Patients With Non-Alcoholic Fatty Liver Disease

Ikizek¹,

Kasapoğlu

Türkay³

2020

Journal of Gastroenterology and Hepatology Research

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Expression of resistin in the liver of patients with non-alcoholic fatty liver disease

Cited by 15 publications

References 22 publications

Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia: A Mutual Ambiguous Relationship in the Development of Metabolic Diseases

Macrophages, Low-Grade Inflammation, Insulin Resistance and Hyperinsulinemia: A Mutual Ambiguous Relationship in the Development of Metabolic Diseases

Cytokines and Abnormal Glucose and Lipid Metabolism

Investigation of Adiponectin, Leptin, Retinol Binding Protein-4 and Resistin Levels in Non-Diabetic and Non-Obese Patients With Non-Alcoholic Fatty Liver Disease

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