Expression of S100A2 and S100A4 Predicts for Disease Progression and Patient Survival in Bladder Cancer

Matsumoto, Kazumasa; Irie, Akira; Satoh, Takefumi; Ishii, Junichiro; Iwabuchi, Kazuya; Iwamura, Masatsugu; Egawa, Shin; Baba, Shirō

doi:10.1016/j.urology.2007.04.007

Cited by 49 publications

(37 citation statements)

References 16 publications

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“…The role of S100A4 in tumor progression and metastasis via induction of epithelial to mesenchymal transition (EMT) has been confirmed in many types of cancer including CRC (21).The positive relationship between S100A4 expression and aggressiveness was also observed in advanced-stage endometrial cancer (22) and bladder cancer (23). These findings suggest that S100A4 overexpression is involved in the growth, invasion, and metastasis of CRC and may serve as an indicator of the aggressiveness of CRC in the clinicopathological practice.…”

Section: Discussionmentioning

confidence: 83%

Immunohistochemical Expressionof S100a4 and Cd24 in Colorectal Adenoma and Carcinoma.

Ibrahim¹

2016

IJAR

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Background:-Colorectal carcinoma (CRC) is a major cause of morbidity and mortality worldwide. Both calcium-binding protein, S100A4, and the cell adhesion molecule, CD24, have been implicated to play an important role in carcinogenesis and tumor progression in various human malignancies. Aim:-To evaluate the expressionof S100A4 and CD24 in colorectal tumors and their role in development and progression of CRC and correlate their expression with the clinicopathological features. Methods:-S100A4 and CD24 expression was analyzed by immunohistochemistry in paraffin-embedded specimens of colorectal adenomas (n=18) and CRC (n=40). Results:-S100A4 and CD24 expression was detected in 28/40 (70%) and 24/40 (60%) of CRC respectively.The positive expression rates of S100A4 and CD24 were significantly higher in CRC than adenomas (P<0.05). S100A4 was significantly expressed in tumors with high histological grades (P= 0.03).A statistically significant relationship was found between S100A4 and CD24 expression and advanced tumor stage (P= 0.009 and =0.03), lymph node metastasis (P=0.04 and =0.0001) and lymph-vascular space invasion (LVSI) (P=0.02 and =0.008) respectively, but not with the age, gender and tumor size (P>0.05). Conclusion:-S100A4 and CD24 up-regulation may be associated with the development and progression of CRC. Combined detection of S100A4 and CD24 may serve as an indicator of the aggressive behavior and poor prognosis of CRC.

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Section: Discussionmentioning

confidence: 83%

Immunohistochemical Expressionof S100a4 and Cd24 in Colorectal Adenoma and Carcinoma.

Ibrahim¹

2016

IJAR

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“…35 Consequently, several carcinomas were shown to express S100A4, including pancreatic carcinomas, bladder cancer and breast carcinoma. [36][37][38] Zhao and colleagues found S100A4 expression in a small series of extrahepatic cholangiocarcinomas (8/10 cases) and biliary high-grade dysplasia (5/6 cases) but not in any of the investigated normal mucosa samples (0/10 cases). 28 In our Immunophenotyping of ampullary tumors D Baumhoer et al series, strong immunoreactivity against S100A4 was also virtually absent in normal mucosa samples (1/122, 1%).…”

Section: Discussionmentioning

confidence: 99%

Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater

et al. 2009

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Carcinomas of the Vaterian system are rare and presumably arise from preexisting adenomas (adenomacarcinoma-sequence). Usually, biopsies are obtained to confirm and specify endoscopic findings, but differentiating reactive atypia from dysplasia or dysplasia from invasive carcinoma can sometimes be difficult or even impossible on morphological criteria alone. In case of invasive carcinoma, furthermore, the precise classification of carcinoma subtypes needs to be established since the distinct subtypes differ significantly in terms of clinical outcome. The cell adhesion proteins CD24, P-cadherin and S100A4 were shown to be expressed in several carcinomas and in dysplastic epithelium but only rarely in normal mucosa. We therefore investigated their expression in 177 carcinoma, 114 adenoma and 152 normal mucosa specimens of the ampulla of Vater. Although the expression of the cell adhesion proteins did not differ between the carcinoma subtypes, marked differences between normal mucosa, adenoma and carcinoma samples were observed. All marker proteins were expressed in less than 7% of normal mucosa samples (S100A4 in only 1% of cases) and showed an increasing expression from adenoma to invasive carcinoma. Our findings suggest that P-cadherin and S100A4 are helpful in discriminating normal mucosa or reactive atypia from neoplastic lesions. CD24 and S100A4, furthermore, can assist in the differential diagnosis of dysplasia vs invasive carcinoma.

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“…S100 proteins are damageassociated molecular pattern molecules which can function as pro-inflammatory factors of innate immunity (41). S100A2 has been reported to both promote tumor growth (42) and function as a tumor suppressor gene (40,43). S100A7 is overexpressed in breast cancer (44), epithelial skin tumors (45), bladder cancer (46), and is markedly elevated in lesions from psoriasis patients (47), suggesting a role in keratinocyte differentiation, and in regulating the innate immune response associated with epithelial inflammation (46).…”

Section: Discussionmentioning

confidence: 99%

Immune Dysregulation and Tumor-Associated Gene Changes in Recurrent Respiratory Papillomatosis: A Paired Microarray Analysis

DeVoti

Rosenthal

et al. 2008

Mol Med

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Recurrent respiratory papillomas (RRP) are benign airway tumors, caused primarily by human papillomaviruses (HPV) types 6 and 11. The disease is characterized by multiple recurrences after surgical removal, with limited effective therapy. To identify novel targets for future therapy, we established transcriptional profiles for actively growing papillomas compared with autologous, clinically normal, laryngeal epithelia (adjacent tissue). Total ribonucleic acid (RNA) from 12 papillomas and 12 adjacent tissues were analyzed by microarray, and the matched sets of tissues compared by paired t test, to identify differentially expressed genes in papilloma tissues while minimizing variations intrinsic to individual patients. Quantitative polymerase chain reaction (PCR) was used to confirm the relative expression levels for a subset of genes. Within the 109 differentially expressed transcripts whose expression varied at least three-fold were two large groups of genes with related functions. The first group consisted of 18 genes related to host defense, including both innate and adaptive immunity. The second group contained 37 genes that likely contribute to growth of papillomas as benign tumors, since the altered pattern of expression also had been reported previously in many cancers. Our results support our previous studies that document a systemic T H 2-like adaptive immune response in RRP, and suggest that there is a role for altered innate immunity in RRP as well. We propose that HPV 6 and 11 infection establishes a tumorigenic microenvironment characterized by alteration of both innate inflammatory signals and adaptive immune responses that prevent effective T H 1-like response, in conjunction with altered expression of numerous genes that regulate cellular growth and differentiation.

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Expression of S100A2 and S100A4 Predicts for Disease Progression and Patient Survival in Bladder Cancer

Cited by 49 publications

References 16 publications

Immunohistochemical Expressionof S100a4 and Cd24 in Colorectal Adenoma and Carcinoma.

Immunohistochemical Expressionof S100a4 and Cd24 in Colorectal Adenoma and Carcinoma.

Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater

Immune Dysregulation and Tumor-Associated Gene Changes in Recurrent Respiratory Papillomatosis: A Paired Microarray Analysis

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