Expression of S100A8 correlates with inflammatory lung disease in congenic mice deficient of the cystic fibrosis transmembrane conductance regulator

Tirkos, Sam; Newbigging, Susan; Nguyen, Van Dan; Keet, Mary; Ackerley, Cameron; Kent, Geraldine; Rozmahel, Richard

doi:10.1186/1465-9921-7-51

Cited by 23 publications

(17 citation statements)

References 90 publications

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“…B6-CFTR tm1UNC mouse lungs also show inflammatory cell recruitment with an influx of neutrophils observed. This inflammatory disease phenotype appears spontaneous, as analysed mice were housed in SPF conditions with no airway pathogens detected prior to, or during the onset of inflammation [66].…”

Section: Congenic Cftr Knockout Mouse Modelmentioning

confidence: 99%

“…The B6-CFTR tm1UNC mouse is one of the few models that exhibits inflammatory lung disease, as such it has proven useful for exploring the long-debated question of whether inflammation in CF airways is spontaneous, or induced by infection [66]. Even though the B6-CFTR tm1UNC mouse demonstrates aspects of CF lung disease, the original mixed-background CF mouse strains continued to be used.…”

Section: Congenic Cftr Knockout Mouse Modelmentioning

confidence: 99%

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Airway disease phenotypes in animal models of cystic fibrosis

2018

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In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection, inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary manifestations in CF mouse models has hindered investigations of airway disease pathogenesis, as well as the development and testing of potential therapeutics. However, recently generated CF animal models including rat, ferret and pig models demonstrate a range of well characterised lung disease phenotypes with varying degrees of severity. This review discusses the airway phenotypes of currently available CF animal models and presents potential applications of each model in airway-related CF research.

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Section: Congenic Cftr Knockout Mouse Modelmentioning

confidence: 99%

Section: Congenic Cftr Knockout Mouse Modelmentioning

confidence: 99%

Airway disease phenotypes in animal models of cystic fibrosis

2018

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“…Until now, over 90 potential target proteins have been identified [23]. Many studies have observed an altered expression of various S100 proteins in a large number of diseases including cancer, depression, Down syndrome, Alzheimer disease and cystic fibrosis [1,13,14,26,28,29]. Therefore, S100 proteins could constitute important diagnostic markers as well as therapeutic targets of many diseases.…”

Section: Introductionmentioning

confidence: 99%

Chromosomal mapping, differential origin and evolution of theS100gene family

2008

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-S100 proteins are calcium-binding proteins, which exist only in vertebrates and which constitute a large protein family. The origin and evolution of the S100 family in vertebrate lineages remain a challenge. Here, we examined the synteny conservation of mammalian S100A genes by analysing the sequence of available vertebrate S100 genes in databases. Five S100A gene members, unknown previously, were identified by chromosome mapping analysis. Mammalian S100A genes are duplicated and clustered on a single chromosome while two S100A gene clusters are found on separate chromosomes in teleost fish, suggesting that S100A genes existed in fish before the fish-specific genome duplication took place. During speciation, tandem gene duplication events within the cluster of

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“…Expression of these functional proteins is often associated with inflammatory conditions such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, cystic fibrosis and psoriasis [69][70][71][72][73].…”

Section: (Figure 2) Inos Breaks Down L-arginine Into Nitric Oxide (Nmentioning

confidence: 99%

Myeloid Derived Suppressor Cells and Their Role in Diseases

Kong¹,

Fuchsberger

Xiang

et al. 2013

CMC

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Abstract:Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid progenitors that can play a major role in tumour development and chronic inflammation. The importance of the suppressive function of MDSCs was first suggested by studies involving cancer patients and cancer-bearing mice. In addition, recent studies have demonstrated that MDSCs can also be involved in many other pathological conditions. MDSCs have unique ways of abrogating an immune response in addition to those utilised by other immune-suppressive cell types, for example via the induction of arginase-1 and consequent upregulation in reactive oxygen species (ROS) production. Due to their heterogeneity, they further can express a variety of lineage markers, which overlap with other myeloid cell types such as Gr1, CD11b, MHCII lo , Ly6C and Ly6G, making it difficult to identify them by surface phenotype alone. The disparity between mouse and human MDSCs further complicates the identification of these elusive cell populations. In this review, we will summarise the recent updates on the methods for eliciting and studying different MDSC subsets, including newly proposed surface phenotypes, as well as insights into how their function is being characterised in both mice and humans. In addition, exciting new discoveries suggesting their involvement across a number of different pathological settings, such as sepsis, autoimmunity and Leishmaniasis, will be discussed.

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Expression of S100A8 correlates with inflammatory lung disease in congenic mice deficient of the cystic fibrosis transmembrane conductance regulator

Cited by 23 publications

References 90 publications

Airway disease phenotypes in animal models of cystic fibrosis

Airway disease phenotypes in animal models of cystic fibrosis

Chromosomal mapping, differential origin and evolution of theS100gene family

Myeloid Derived Suppressor Cells and Their Role in Diseases

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