Expression of S100B protein levels in serum and cerebrospinal fluid with different forms of neuropsychiatric systemic lupus erythematosus

Abstract

The aim of this study is to determine S100B protein levels in serum and cerebrospinal fluid (CSF) in patients with different forms of neruopsychiatric systemic lupus erythematosus (NPSLE). There were 157 SLE patients (65 with and 92 without NPSLE, and 20 patients without rheumatic diseases served as controls) recruited in the present study. Serum and CSF S100B protein levels were measured by ELISA assay. Serum S100B protein levels in patients with NPSLE (0.179 +/- 0.095 microg/l) were significantly higher than the levels in patients without NPSLE (0.110 +/- 0.091 microg/l; p < 0.001) and in controls (0.103 +/- 0.065 microg/l; p = 0.005). Thus, the differences in serum levels between non-NPSLE patients and controls had no statistical significance. The serum and CSF S100B protein contents in patients with organic brain syndrome, seizures, cerebral vascular accident, and psychosis were significantly higher than those in controls (all p < 0.001). However, there was no significant difference in serum and CSF S100B protein levels among patients with headache, patients with neuropathy, and controls. In conclusion, serum and CSF S100B levels were raised in NPSLE, especially concerning patients with organic brain syndrome, seizures, cerebral vascular accident, and psychosis. The results obtained imply that S100B protein is possibly an available and complementary biochemical marker within evaluation of NPSLE and deserves further study.

Comparative proteome analysis of peripheral blood mononuclear cells in systemic lupus erythematosus with iTRAQ quantitative proteomics

“…It supports that resistin has proinflammatory and disease-promoting properties in SLE. There is growing evidence showing that calcium-binding family of S100 proteins form a new group of pro-inflammatory proteins and act as pleiotropic roles in inflammatory arthritis [19,20]. Notably, we observed elevated levels of S100 P and S100 A12 in active SLE, while levels of S100 A8, S100 A9, and S100 A12 were significant lower in stable SLE.…”

A lack of association between elevated serum levels of S100B protein and autoimmunity in autistic children

“…This may imply that S100B protein might serve as an available and complementary biochemical marker within evaluations of NPSLE. The association of anti-double-stranded DNA (anti-dsDNA) antibodies with higher S100B protein levels may indicate that raised serum levels of S100B protein may reflect continuing neurological damage [6,7,52]. …”

Association between Cerebrospinal Fluid S100B Protein and Neuronal Damage in Patients with Central Nervous System Infections

“…Connolly, et al26 reported a correlation between S100B concentrations and neurocognitive decline after carotid endarterectomy. A recent study of serum S100B protein in patients with systemic lupus erythematosis (SLE) reported that S100B levels were notably raised in SLE patients with neuropsychiatric manifestations and were related to the degree of neurological injury 27,28. CSF and serum S100B levels decreased and neuropsychiatric manifestations improved after 3 months in patients who accepted a standardized treatment, suggesting that the neuropsychiatric manifestations were induced by anti-neuronal antibodies, which ultimately caused neuron destruction and alterations in excitability 27.…”