Expression of SmATPDases 1 and 2 in Schistosoma mansoni eggs favours IL‐10 production in infected individuals
Thalisson Artur Ribeiro Gomides,
Márcio Luís Moreira de Souza,
Amanda Braga de Figueiredo
et al.
Abstract:A role of IL‐10 is down‐regulating T‐cell responses to schistosome antigens. Since SmATPDases can be correlated to modulation of the immune response, we evaluated the expression of enzymes in S. mansoni eggs. Faecal samples were collected from 40 infected individuals to detect coding regions of the SmATPDases. The cytokines were measured in supernatants of PBMC. The analysis was performed by the global median determination and set up high producers (HP) of cytokines. Six individuals expressed SmATPDase1, six e… Show more
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