2006
DOI: 10.1016/j.jdermsci.2006.03.008
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Expression of SERCA2 (Darier's disease gene product) in acantholytic dermatoses

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“…Translation, translocation, folding, and processing of adhesional molecule of keratinocyte are closely related with Ca 2+ levels; mutations affecting the Ca 2+ pumps induce histologically acantholysis and dyskeratosis 3 . An earlier study revealed that SERCA2 and SPCA1 staining was less intense than normal in both DD and HHD skin, but SERCA2 was more affected in DD patients and SPCA1 in those with HHD 4 5 . We found that the SERCA2 staining intensity was similar in both tissues, but SPCA1 expression level was much reduced in IFAD compared to normal tissue.…”
mentioning
confidence: 93%
“…Translation, translocation, folding, and processing of adhesional molecule of keratinocyte are closely related with Ca 2+ levels; mutations affecting the Ca 2+ pumps induce histologically acantholysis and dyskeratosis 3 . An earlier study revealed that SERCA2 and SPCA1 staining was less intense than normal in both DD and HHD skin, but SERCA2 was more affected in DD patients and SPCA1 in those with HHD 4 5 . We found that the SERCA2 staining intensity was similar in both tissues, but SPCA1 expression level was much reduced in IFAD compared to normal tissue.…”
mentioning
confidence: 93%