Expression of serum AMPD1 in thyroid carcinoma and its clinical significance

Abstract

This study investigated the expression of adenosine monophosphate deaminase 1 (AMPD1) in serum of patients with papillary thyroid carcinoma (PTC) and its clinical significance. The expression levels of AMPD1 mRNA in serum of 157 patients with PTC and 100 normal controls were detected by real-time fluorescent quantitative polymerase chain reaction (PCR), and the relationships between expression level of AMPD1 in serum of PTC patients and clinicopathological factors as well as prognosis were analyzed. The results of real-time fluorescent quantitative PCR showed that the expression of AMPD1 mRNA in serum of PTC patients was lower than that in normal human serum (P<0.01). The expression of AMPD1 in serum of PTC patients was not significantly different from the clinicopathological features such as sex, age, lymph node metastasis and the number of lesions (P>0.05); there were distinct differences between its expression and tumor-node-metastasis (TNM) staging and tumor diameter (P<0.05). The single factor Cox analysis revealed that sex, age, number of lesions, TNM staging and the occurrence of lymph node metastasis were significantly correlated with the prognosis of patients (P<0.05). Multivariate Cox analysis showed that TNM staging hazard ratio (HR)=2.93, 95% confidence interval (CI): 1.52–7.04, P=0.015 was an independent prognostic factor in PTC patients. Survival analysis indicated that there was a statistically significant difference in the 5-year overall survival rate between patients with high expression of AMPD1 and those with low expression (P=0.007). In conclusion, the expression of AMPD1 in serum of patients with PTC is closely related to the malignant evolution of PTC and clinical prognosis of patients. AMPD1 is expected to become an important molecule in judging the clinical prognosis of PTC patients, and may become a new target for molecular targeted therapy of PTC.

Analysis of prognostic genes in the tumor microenvironment of lung adenocarcinoma

“…Luo et al (2018) identified that AMPD1 was closely associated with the survival of breast cancer patients. Zha & Wu (2018) found that the expression of AMPD1 in serum of patients with papillary thyroid carcinoma is closely related to the malignant evolution of PTC and clinical prognosis of patients. The relationship between AMPD1 and LUAD has not previously been elucidated.…”

Characteristics of immune cell infiltration and associated diagnostic biomarkers in ulcerative colitis: results from bioinformatics analysis

“…AMPD1, a metabolism-related gene, encodes adenosine monophosphate deaminase. Recent studies suggest that AMPD1 is closely associated with the prognosis of tumors [ 40 , 41 ]. However, the role of AMPD1 in UC or other inflammatory bowel diseases was not previously been elucidated.…”

Construction of a Prognostic Signature in Ewing’s Sarcoma: Based On Metabolism-Related Genes

“…Therefore, AMPD1 can be used as a clinical molecular marker to judge the prognosis of patients, and even become a new therapeutic target. [23] . ENPP1 has been found to be related to the stemness of tumor cells in cancers such as breast cancer and glioblastoma, and is involved in tumor occurrence, nausea growth and metastasis.…”