Expression of serum amyloid A in uterine cervical cancer

Ren, Yanjie; Wang, He; Lu, Donghao; Xie, Xiaoyan; Chen, Xinlian; Peng, Jing; Hu, Qian; Su, Gang; Liu, Shanling

doi:10.1186/1746-1596-9-16

Cited by 38 publications

(33 citation statements)

References 35 publications

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“…Recent studies reported that cancer tissue might be a major source of SAA outside of the liver, such as in the patients with esophagus, lung, pancreas, ovary, uterine endometrium or uterine cervical cancer [17–22]. In this study, we showed the presence of SAA protein in both tumor cells and macrophages in human breast carcinomas, and significantly more frequent expression of SAA mRNA in macrophages than tumor cells.…”

Section: Discussionsupporting

confidence: 66%

“…Therefore, overexpression of SAA protein in tumor cells may reflect a high level of SAA protein secreted by the TAM in tumor microenvironment of breast cancer. In contrast, many researchers studied the local SAA genes' expression by RT-PCR analysis on RNA extracted from cancer biopsy specimens and speculated that the tumor cells are the main secretion source of SAA in local tumor tissues [21, 22]. One limitation of this method, unless combining tissue microdissection technique, is its inability to identify the location and secretion source in the complex cell components in tumor microenvironment.…”

Section: Discussionmentioning

confidence: 99%

“…The activation of these genes could suppress apoptosis [16]. Recent studies have revealed other sources of SAA outside of the liver: specifically, the cancer tissues of the esophagus, lung, pancreas, ovary, uterine endometrium and uterine cervical cancer [17–22]. However, the association of its expression in different distributions of tumor tissue with clinicopathological features and prognosis in cancer tissues has not been well described.…”

Section: Introductionmentioning

confidence: 99%

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Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis

Liu

Higuchi

et al. 2016

Oncotarget

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BackgroundSerum amyloid A (SAA), an acute-phase protein, is expressed primarily in the liver, and recently found also expressed in cancer tissues. However, its expression and prognostic value in breast cancer have not been described.ResultsSAA protein was found expressed in tumor cells in 44.2% cases and in TAM in 62.5% cases. FISH showed more frequent SAA mRNA expression in TAM than in tumor cells (76% versus 12%, p < 0.001), and a significant association between the frequencies of SAA mRNA expression in TAM and tumor cells (rs = 0.603, p < 0.001). The immunoreactivities of SAA protein in TAM and tumor cells were both associated with lymphovascular invasion and lymph node metastasis. Moreover, SAA-positivity in TAMs was associated with larger tumor-size, higher histological-grade, negative estrogen-receptor and progesterone-receptor statuses, and HER-2 overexpression. It was also linked to worse recurrence-free survival in a multivariable regression model.MethodsImmunohistochemistry was applied on the tumor tissues from 208 breast cancer patients to evaluate the local SAA-protein expression with additional CD68 stain to identify the tumor-associated macrophage (TAM) on the serial tissue sections. Fluorescent in situ hybridization (FISH) was conducted on serial tissue sections from 25 of the 208 tumors to examine the expression and location of SAA mRNA.ConclusionsOur results suggested that the TAMs may be a pivotal and main source of SAA production in tumor microenvironment of breast cancer. SAA immunoreactivity in TAM is associated with worse recurrence-free survival, and is therefore a biomarker candidate for postoperative surveillance and perhaps a therapeutic target for breast cancer.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis

Liu

Higuchi

et al. 2016

Oncotarget

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“…17,27,28,30 Lungs and lymph nodes are the most involved sites with distant metastasis from primary CNS tumors suggesting hematogenous and lymphogeneous pathways of dissemination.…”

Section: Discussionmentioning

confidence: 99%

“…However, in event of a surgery, these conditions may be violated, increasing risk of metastasis. 17,31 …”

Section: Discussionmentioning

confidence: 99%

Osteosclerosis Secondary to Metastatic Oligodendroglioma

et al. 2016

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This paper reviews a case of metastatic 1p/19q codeleted oligodendrioglioma causing diffuse osteosclerosis and pain. Primary central nervous system (CNS) tumors rarely metastasize outside the CNS, and metastatic oligodendroglioma is rarer still. The patient in this study had relief of pain after being treated with temozolomide. We discuss this rare presentation and potential treatment options, and review the literature in regards to metastatic oligodendrogliomas.

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Serum amyloid A1 in combination with integrin αVβ3 increases glioblastoma cells mobility and progression

et al. 2018

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Glioblastoma multiforme (GBM) is a highly malignant type of brain tumor found in humans. GBM cells reproduce quickly, and the median survival time for patients after therapy is approximately 1 year with a high relapse rate. Current therapies and diagnostic tools for GBM are limited; therefore, we searched for a more favorable therapeutic target or marker protein for both therapy and diagnosis. We used mass spectrometry (MS) analysis to identify GBM‐associated marker proteins from human plasma and GBM cell cultures. Additional plasma and 52 brain tissues obtained from patients with gliomas were used to validate the association rate of serum amyloid A1 (SAA1) in different grades of gliomas and its distribution in tumors. Microarray database analysis further validated the coefficient of SAA1 levels in gliomas. The cellular mechanisms of SAA1 in GBM proliferation and infiltration were investigated in vitro. We analyzed the correlation between SAA1 and patients' medication requirement to demonstrate the clinical effects of SAA1 in GBM. SAA1 was identified from MS analysis, and its level was revealed to be correlated with the disease grade, clinical severity, and survival rate of patients with gliomas. In vitro cultures, including GBM cells and normal astrocytes, revealed that SAA1 promotes cell migration and invasion through integrin αVβ3 to activate the Erk signaling pathway. Magnetic resonance imaging and tumor region‐specific microarray analysis identified a correlation between SAA1 and GBM cell infiltration in patients. In summary, our results demonstrate that SAA1 in combination with integrin αV and β3 can serve as an indicator of high glioblastoma risk. We also identified the cellular mechanisms of SAA1 contributing to GBM progression, which can serve as the basis for future GBM therapy.

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Expression of serum amyloid A in uterine cervical cancer

Cited by 38 publications

References 35 publications

Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis

Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis

Osteosclerosis Secondary to Metastatic Oligodendroglioma

Serum amyloid A1 in combination with integrin αVβ3 increases glioblastoma cells mobility and progression

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