Expression of serum- and glucocorticoid-regulated kinase 1 and its association with clinicopathological factors and the survival of patients with adenocarcinoma of the esophagogastric junction

Gao, Shegan; Wang, Dan; Kong, Guangwen; Li, Shuoguo; Wang, Wei; Wang, Huizhi; Zhou, Fuyou

doi:10.3892/ol.2017.5927

Cited by 7 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, Sgk1 could also enhance tumor cell invasion and migration of ESCC, as reported for other human malignancies such as esophagogastric junctional adenocarcinoma [17], colorectal cancer [18], and non-small cell lung carcinoma [38].…”

Section: Discussionmentioning

confidence: 54%

GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy

Ueki

Fujishima

Konno

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Esophageal squamous cell carcinoma (ESCC) is a highly malignant neoplasm. Glucocorticoid(GC)-Glucocorticoid receptor (GR) pathway plays pivotal roles in cellular response to various stresses of tumor cells including chemotherapy. However, the status of GC-GR pathway in ESCC, including its correlation with chemotherapeutic responses has remained largely unknown.Method GR, serum-and glucocorticoid-regulated kinase 1(Sgk1), and N-myc down regulation gene 1(NDRG1) were immunolocalized in 98 ESCC patients who had undergone esophagectomy following neoadjuvant chemotherapy(NAC) with 2 courses of 5-Fluorouracil(5-FU) + Cisplatin (CDDP). We also examined biopsy specimens before NAC in 42 cases and compared the results between those before and after NAC. Results Overall survival (OS) of the patients treated with surgery following NAC was significantly shorter in the group with high GR than that with low GR ( P = 0.0473). Both OS and disease-free survival (DFS) were significantly shorter in both Sgk1-and NDRG1-high groups than low groups (OS: Sgk1, P = 0.0055; NDRG1, P = 0.0021; DFS: Sgk1, P = 0.0240; NDRG1, P = 0.0086).When evaluating the findings in biopsy specimens before NAC, DFS was significantly shorter in the high Sgk1 group ( P = 0.0095), and both OS and DFS was shorter in high NDRG1 group (OS, P = 0.0233; DFS, P = 0.0006) than respective low groups. Among high NDRG1 group of biopsy specimens before NAC, the tumor reduction rate by NAC was significantly attenuated ( P = 0.021). Conclusions High status of GR, Sgk1, and NDRG1 in ESCC after NAC was significantly associated with over all worse prognosis and there were no significant changes in the status of those above before and after NAC. Therefore , increased activity of GC-GR pathway with enhanced induction of Sgk1 and NDRG1 in carcinoma cells plays pivotal roles in tumor progression and development of chemoresistance in ESCC patients undergoing NAC. BackgroundEsophageal cancer is the eighth most common human malignancy and the sixth most common cause of cancer deaths worldwide [1]. The standard treatment consists of surgical resection of locally advanced esophageal squamous cell carcinoma (ESCC) following neoadjuvant chemotherapy (NAC)[2]. However, the therapeutic effects of chemotherapy widely vary among cases, and satisfactory

show abstract

Section: Discussionmentioning

confidence: 54%

GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy

Ueki

Fujishima

Konno

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, Sgk1 may also enhance tumor cell invasion and migration in ESCC, as reported for other human malignancies such as esophagogastric junctional adenocarcinoma [17], colorectal cancer [18], and non-small cell lung carcinoma [38].…”

Section: Discussionmentioning

confidence: 83%

GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy

Ueki

Fujishima

Konno

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Esophageal squamous cell carcinoma (ESCC) is a highly malignant neoplasm. Glucocorticoid(GC)-Glucocorticoid receptor (GR) pathway plays pivotal roles in cellular response to various stresses of tumor cells including chemotherapy. However, the status of GC-GR pathway in ESCC, including its correlation with chemotherapeutic responses has remained largely unknown. Method GR, serum-and glucocorticoid-regulated kinase 1(Sgk1), and N-myc down regulation gene 1(NDRG1) were immunolocalized in 98 ESCC patients who had undergone esophagectomy following neoadjuvant chemotherapy(NAC) with 2 courses of 5-Fluorouracil(5-FU) + Cisplatin (CDDP). We also examined biopsy specimens before NAC in 42 cases and compared the results between those before and after NAC. Results Overall survival (OS) of the patients treated with surgery following NAC was significantly shorter in the group with high GR than that with low GR ( P = 0.0473). Both OS and disease-free survival (DFS) were significantly shorter in both Sgk1- and NDRG1-high groups than low groups (OS: Sgk1, P = 0.0055; NDRG1, P = 0.0021; DFS: Sgk1, P = 0.0240; NDRG1, P = 0.0086). When evaluating the findings in biopsy specimens before NAC, DFS was significantly shorter in the high Sgk1 group ( P = 0.0095), and both OS and DFS was shorter in high NDRG1 group (OS, P = 0.0233; DFS, P = 0.0006) than respective low groups. Among high NDRG1 group of biopsy specimens before NAC, the tumor reduction rate by NAC was significantly attenuated ( P = 0.021). Conclusions High status of GR, Sgk1, and NDRG1 in ESCC after NAC was significantly associated with over all worse prognosis and there were no significant changes in the status of those above before and after NAC. Therefore , increased activity of GC-GR pathway with enhanced induction of Sgk1 and NDRG1 in carcinoma cells plays pivotal roles in tumor progression and development of chemoresistance in ESCC patients undergoing NAC.

show abstract

“…Sgk1 is well known to activate betacatenin/T cell factor signaling in human non-small cell lung cancer, and to be associated with tumor cell invasion and migration [31]. Therefore, Sgk1 could also enhance tumor cell invasion and migration of ESCC, as reported for other human malignancies such as esophagogastric junctional adenocarcinoma [32], colorectal cancer [33], and non-small cell lung carcinoma [31].…”

Section: Discussionmentioning

confidence: 88%

GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy

et al. 2020

View full text Add to dashboard Cite

Background: Esophageal squamous cell carcinoma (ESCC) is a highly malignant neoplasm. The glucocorticoid (GC)-glucocorticoid receptor (GR) pathway plays pivotal roles in cellular response to various stresses of tumor cells, including chemotherapy. However, the status of the GC-GR pathway in ESCC, including its correlation with chemotherapeutic responses, is largely unknown. Methods: GR, serum-and glucocorticoid-regulated kinase 1 (Sgk1), and N-myc down regulation gene 1 (NDRG1) were immunolocalized in 98 patients with ESCC who had undergone esophagectomy following neoadjuvant chemotherapy (NAC) with 2 courses of 5-fluorouracil + cisplatin. We also examined biopsy specimens before NAC in 42 cases and compared the results between those before and after NAC. Results: Overall survival (OS) of the patients treated with surgery following NAC was significantly shorter in the group with high GR than that with low GR status (P = 0.0473). Both OS and disease-free survival (DFS) were significantly shorter in both Sgk1-and NDRG1-high groups than in the low groups (OS: Sgk1, P = 0.0055; NDRG1, P = 0.0021; DFS: Sgk1, P = 0.0240; NDRG1, P = 0.0086). Biopsy specimens before NAC showed significantly shorter DFS in the high Sgk1 group (P = 0.0095), while both OS and DFS were shorter in the high NDRG1 group (OS, P = 0.0233; DFS, P = 0.0006) than in the respective low groups. In the high NDRG1 group of biopsy specimens before NAC, the tumor reduction rate by NAC was significantly attenuated (P = 0.021). Conclusions: High GR, Sgk1, and NDRG1 statuses in ESCC after NAC was significantly associated with an overall worse prognosis, with no significant changes in their expression levels before and after NAC. Therefore, increased activity of the GC-GR pathway with enhanced induction of Sgk1 and NDRG1 in carcinoma cells play pivotal roles in tumor progression and development of chemo-resistance in patients with ESCC undergoing NAC.

show abstract

Expression of serum- and glucocorticoid-regulated kinase 1 and its association with clinicopathological factors and the survival of patients with adenocarcinoma of the esophagogastric junction

Cited by 7 publications

References 33 publications

GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy

GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy

GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy

GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy

Contact Info

Product

Resources

About