Expression of serum lncRNA-Xist in patients with polycystic ovary syndrome and its relationship with pregnancy outcome

Liu, Min; Zhu, Honglin; Yin, Li; Zhuang, Jing; Cao, Ting; Wang, Yi

doi:10.1016/j.tjog.2020.03.006

Cited by 18 publications

(9 citation statements)

References 20 publications

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“…et al, 2020 ), and regulates HT cell proliferation and invasion in human trophoblast (HT) cells via miR-144/Titin axis by activating the downstream MAPK and MMPs pathway ( Yu N.H. et al, 2017 ). In polycystic ovary syndrome (PCOS), lncRNA Xist is correlated with adverse pregnancy outcomes ( Liu et al, 2020c ). In addition, these signaling pathways, which include lncRNA Xist/miR-203-3p/ZFPM2 ( Niu et al, 2020 ), lncRNA Xist/let-7c-5p/STAT3 ( Wang et al, 2020d ), and lncRNA Xist/miR-320/NOD2 ( Xu X.H.…”

Section: The Role Of Lncrna Xist In Non-cancer Diseasesmentioning

confidence: 99%

Biological Function of Long Non-coding RNA (LncRNA) Xist

Wang

Min

Guo

et al. 2021

Front. Cell Dev. Biol.

139

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Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating evidence suggests that lncRNA X-inactive specific transcript (lncRNA Xist) serves as an important regulator of cell growth and development. Despites its original roles in X-chromosome dosage compensation, lncRNA Xist also participates in the development of tumor and other human diseases by functioning as a competing endogenous RNA (ceRNA). In this review, we comprehensively summarized recent progress in understanding the cellular functions of lncRNA Xist in mammalian cells and discussed current knowledge regarding the ceRNA network of lncRNA Xist in various diseases. Long non-coding RNAs (lncRNAs) are transcripts that are more than 200 nt in length and without an apparent protein-coding capacity (Furlan and Rougeulle, 2016; Maduro et al., 2016). These RNAs are believed to be transcribed by the approximately 98–99% non-coding regions of the human genome (Derrien et al., 2012; Fu, 2014; Montalbano et al., 2017; Slack and Chinnaiyan, 2019), as well as a large variety of genomic regions, such as exonic, tronic, and intergenic regions. Hence, lncRNAs are also divided into eight categories: Intergenic lncRNAs, Intronic lncRNAs, Enhancer lncRNAs, Promoter lncRNAs, Natural antisense/sense lncRNAs, Small nucleolar RNA-ended lncRNAs (sno-lncRNAs), Bidirectional lncRNAs, and non-poly(A) lncRNAs (Ma et al., 2013; Devaux et al., 2015; St Laurent et al., 2015; Chen, 2016; Quinn and Chang, 2016; Richard and Eichhorn, 2018; Connerty et al., 2020). A range of evidence has suggested that lncRNAs function as key regulators in crucial cellular functions, including proliferation, differentiation, apoptosis, migration, and invasion, by regulating the expression level of target genes via epigenomic, transcriptional, or post-transcriptional approaches (Cao et al., 2018). Moreover, lncRNAs detected in body fluids were also believed to serve as potential biomarkers for the diagnosis, prognosis, and monitoring of disease progression, and act as novel and potential drug targets for therapeutic exploitation in human disease (Jiang W. et al., 2018; Zhou et al., 2019a). Long non-coding RNA X-inactive specific transcript (lncRNA Xist) are a set of 15,000–20,000 nt sequences localized in the X chromosome inactivation center (XIC) of chromosome Xq13.2 (Brown et al., 1992; Debrand et al., 1998; Kay, 1998; Lee et al., 2013; da Rocha and Heard, 2017; Yang Z. et al., 2018; Brockdorff, 2019). Previous studies have indicated that lncRNA Xist regulate X chromosome inactivation (XCI), resulting in the inheritable silencing of one of the X-chromosomes during female cell development. Also, it serves a vital regulatory function in the whole spectrum of human disease (notably cancer) and can be used as a novel diagnostic and prognostic biomarker and as a potential therapeutic target for human disease in the clinic (Liu et al., 2018b; Deng et al., 2019; Dinescu et al., 2019; Mutzel and Schulz, 2020; Patrat et al., 2020; Wang et al., 2020a). In particular, lncRNA Xist have been demonstrated to be involved in the development of multiple types of tumors including brain tumor, Leukemia, lung cancer, breast cancer, and liver cancer, with the prominent examples outlined in Table 1. It was also believed that lncRNA Xist (Chaligne and Heard, 2014; Yang Z. et al., 2018) contributed to other diseases, such as pulmonary fibrosis, inflammation, neuropathic pain, cardiomyocyte hypertrophy, and osteoarthritis chondrocytes, and more specific details can be found in Table 2. This review summarizes the current knowledge on the regulatory mechanisms of lncRNA Xist on both chromosome dosage compensation and pathogenesis (especially cancer) processes, with a focus on the regulatory network of lncRNA Xist in human disease.

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Section: The Role Of Lncrna Xist In Non-cancer Diseasesmentioning

confidence: 99%

Biological Function of Long Non-coding RNA (LncRNA) Xist

Wang

Min

Guo

et al. 2021

Front. Cell Dev. Biol.

139

View full text Add to dashboard Cite

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“…Wu et al 89 Lnc-OC1 -Its downregulation associated with PCOS, in granulosa cells Lin et al 90 LncRNA GAS5 -Downregulation of lncRNA-GAS5 may contribute to insulin resistance in PCOS patients -From serum Liu et al 91 LncRNA-Xist -Xist downregulation may be involved in PCOS and is correlated with adverse pregnant outcomes in PCOS -From serum Wang et al 92 lncRNA-H19 -high-throughput lncRNA sequencing of follicular fluid exosomes in non-PCOS infertility patients and PCOS infertility patients -In exosomes from follicular fluid -lncRNA-H19 represented the largest node and was predicted to have the potential to interact with 15 target miRNAs Zeng et al 30 lncRNAs (KLF3-AS1, WWC2-AS, and MAPKAPK5-AS1) miRNAs(miR−382) -Construction of a drug molecule and RNA network -Based on co-expression and ceRNA network analyses Zhang et al 93 lncRNA CD36-005 -Identification of mRNAs related to endometrium function regulated by lncRNA CD36-005 in rat endometrial stromal cells -Providing a list of potential target mRNA genes of CD36-005 in endometrial stromal cells and laid a foundation for further studies on the molecular function and mechanism of CD36-005 in the endometrium helping to unfold the PCOS (Continues)…”

Section: Mirnas As Biomarkers For Pcosmentioning

confidence: 99%

microRNAs and long non‐coding RNAs as biomarkers for polycystic ovary syndrome

Tamaddon

Azimzadeh

Tavangar

2022

J Cellular Molecular Medi

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Polycystic ovary syndrome (PCOS) is known as the most common endocrine/metabolic disorder in women of reproductive age, where it is reported that PCOS affects 5 to 26 percent of women (based on the applied diagnostic criteria) around the world. 1,2 PCOS was found to be associated with different diseases such as metabolic syndrome, type 2 diabetes, hypertension, cardiovascular diseases and even ovulatory infertility. 3,4 There are four distinguished subtypes; inflammatory, hidden cause and finally, pill-induced PCOS and insulin-resistant (the most prevalent type). 5,6 Although the complete etiology of the syndrome remains unclear, the genetic, epigenetic, environmental factors and lifestyle have been associated with PCOS causality. In clinical and/or biochemical settings, diagnosis is based on whether the patient shows no less than two out of three main symptoms, including cysts in the ovaries, high androgen levels and irregular periods. Despite the controversial opinions of current diagnostic criteria of PCOS, an expert opinion from the ultrasound, pelvic exam and blood tests can confirm the diagnosis. 7,8 Blood tests for PCOS are mainly based on hormone levels and endocrine function,

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“…Evidence has accumulated showing a vital link between lncRNAs and pregnancy outcomes. For instance, decreased lncRNA X-inactive specific transcript (Xist) is significantly related with adverse pregnancy outcome in PCOS patients, including gestational diabetes, pre-eclampsia, caesarean section, preterm and post-term birth (65). In addition, some up-regulated lncRNAs in blood may reflect the ovarian GC apoptosis, such as lncRNA sorafenib resistance-associated lncRNA in renal cell carcinoma (SRLR) (66) may reflect ovarian GC apoptosis.…”

Section: Lncrnas In Human Peripheral Bloodmentioning

confidence: 99%

Long non-coding RNAs: novel players in the pathogenesis of polycystic ovary syndrome

et al. 2021

Ann Transl Med

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Long non-coding RNAs (lncRNAs) are a class of transcripts (>200 nucleotides) lacking proteincoding capacity. Based on the complex three-dimensional structure, lncRNAs are involved in many biological processes and can regulate the expression of target genes at chromatin modification, transcriptional and post-transcriptional levels. LncRNAs have been studied in multiple diseases but little is known about their role(s) in polycystic ovary syndrome (PCOS), the most common endocrinological disorder in reproductiveaged women around the world. In this review, we characterized and explored the potential mechanisms of lncRNAs in the pathogenesis of PCOS. We found that lncRNAs play a molecular role in PCOS mainly by functioning as the competitive endogenous RNA (ceRNA) and are significantly correlated with some clinical phenotypes. We summarized in detail regarding aberrant lncRNAs in different specimens of women with PCOS [i.e., granulosa cells (GCs), cumulus cells (CCs), follicular fluid (FF), peripheral blood] and various PCOS rodent models [i.e., dehydroepiandrosterone (DHEA) and letrozole induced models]. In clinical practice, detection of lncRNAs in serum might enable early diagnosis. Furthermore, new lncRNAbased classifications might be emerging as potent predictors of a particular phenotype in PCOS. Overall, we proposed new insights for the application of precision medicine approaches to the management of PCOS.

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Expression of serum lncRNA-Xist in patients with polycystic ovary syndrome and its relationship with pregnancy outcome

Cited by 18 publications

References 20 publications

Biological Function of Long Non-coding RNA (LncRNA) Xist

Biological Function of Long Non-coding RNA (LncRNA) Xist

microRNAs and long non‐coding RNAs as biomarkers for polycystic ovary syndrome

Long non-coding RNAs: novel players in the pathogenesis of polycystic ovary syndrome

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