Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy

McGeachie, Michael J.; Sordillo, Joanne E.; Dahlin, Amber; Wang, Alberta L.; Lutz, Sharon M.; Tantisira, Kelan G.; Panganiban, Ronald Allan M; Lu, Quan; Sajuthi, Satria; Urbanek, Cydney; Kelly, Rachel S.; Saef, Benjamin; Eng, Celeste; Oh, Sam S.; Kho, Alvin T.; Croteau‐Chonka, Damien C.; Weiss, Scott T.; Raby, Benjamin A.; Mak, Angel C. Y.; Rodríguez‐Santana, José; Burchard, Esteban G.; Seibold, Max A.; Wu, Ann Chen

doi:10.1186/s12931-020-1295-4

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…Alveolar macrophages, T lymphocytes (especially CD8 + cells) and neutrophils aggregate in various pulmonary foci, and a subset of patients develop eosinophil-enriched in ammation [1] . Glucocorticoid (GC) is currently recognized as the most rapidly acting and potent anti-in ammatory drugs in the therapy of chronic in ammatory airway diseases, and have demonstrated good clinical e cacy in the treatment of bronchial asthma [2,3] . However, COPD patients do not bene t from inhaled corticosteroids (ICS) alone.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Network Pharmacology and Molecular Docking Study of Jinwei Decoction for Enhancement of Glucocorticoid Anti-Inflammatory Effect in COPD through miR-21

Zhang

Chen

et al. 2021

Preprint

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PurposeJinwei decoction can enhance the anti-inflammatory effect of glucocorticoid (GC) on chronic obstructive pulmonary disease (COPD) by restoring the activity of HDAC2. But the upstream mechanism of Jinwei decoction on HDAC2 expression is not clear. ObjectiveTo explore whether Jinwei decoction can enhance the anti-inflammatory effect of GC on COPD through microRNA21 (miR-21) by network pharmacology. MethodsThe TCMSP database was used to screen active ingredients and target genes of Jinwei decoction, and miRWalk2.0 was used to predict downstream target genes of miR-21. COPD-related genes were identified by searching GeneCards and OMIM databases; Venny 2.1 was used to screen intersection genes; Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of intersection genes were analyzed by R software. Protein-protein interactions (PPIs) were analyzed by Cytoscape 3.7.2 software to identify core genes. Finally, interactions between main compounds and potential targets were verified by molecular docking. ResultsTwo hundred ninety-two active ingredients, 316 Jinwei drug targets, 10170 miR-21 target genes, 6617 COPD target genes, and 184 intersection gene were identified. Eleven core proteins of PPI networks may be involved. GO enrichment analysis showed that oxidative stress, regulation of inflammatory response, hormone transport, and histone modification were involved; KEGG pathway enrichment analysis concentrated in the PI3K-Akt, mitogen-activated protein kinase (MAPK), HIF-1, neutrophil extracellular bactericidal network, and other signaling pathways. ConclusionJinwei decoction can regulate histone deacetylase-2 activity and enhance the anti-inflammatory effect of GC on COPD by modulating miR-21. Its mechanism of action may be related to its effect on the PI3K Akt, MAPK, and TNF signaling pathways and neutrophil extracellular trap formation through miR-21.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Network Pharmacology and Molecular Docking Study of Jinwei Decoction for Enhancement of Glucocorticoid Anti-Inflammatory Effect in COPD through miR-21

Zhang

Chen

et al. 2021

Preprint

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“…Some studies have suggested the existence of transcriptional changes in PBMCs after RV infection 74,75 . McGeachie et al 76 also demonstrated the influence of the patient's age on the expression of SMARCD1 in lymphocytes with effects on asthma control despite inhaled corticosteroids (ICS) use. Nonetheless, the analysis of transcriptome data obtained through NGS technologies (RNA‐seq) in the GxE field is highly promising, which can be demonstrated by the recent evidence of changes in gene expression levels that might affect asthma in interaction with psychosocial factors 77 …”

Section: Expanding the Gene‐environment Conceptmentioning

confidence: 99%

“…4 Some studies have suggested the existence of transcriptional changes in PBMCs after RV infection. 74,75 McGeachie et al 76 also demonstrated the influence of the patient's age on the expression of SMARCD1 in lymphocytes with effects on asthma control despite inhaled corticosteroids (ICS) use. Nonetheless, the analysis of transcriptome data obtained through NGS technologies (RNA-seq)…”

Section: Emerging Omics Approaches In the Gxe Fieldmentioning

confidence: 99%

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Hernandez‐Pacheco

Kere

2022

Pediatric Allergy Immunology

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Investigation of gene‐environment interactions (GxE) may provide important insights into the gene regulatory framework in response to environmental factors of relevance for childhood asthma. Over the years, different methodological strategies have been applied, more recently using genome‐wide approaches. The best example to date is the major asthma locus on the 17q12‐21 chromosome region, viral infections, and airway epithelium processes where recent studies have shed much light on mechanisms in childhood asthma. However, there are challenges with the traditional single variant—single exposure interaction models, as they do not encompass the complexity and cumulative effects of multiple exposures or multiple genetic variants. As such, we need to redefine our traditional GxE thinking, and we propose in this review to expand the GxE concept by also evaluating other omics layers, such as epigenetics, transcriptomics, metabolomics, and proteomics. In addition, host factors such as age, gender, and other exposures are very likely to influence GxE effects and need firmly to be considered in future studies.

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“…Recent studies have demonstrated the phenomenon of inflammaging and immunosenescence among the elderly, leading to worsened disease outcomes in the context of acute and chronic inflammatory diseases ( 9 ). Moreover, studies indicate that the characteristic hallmarks of cellular aging such as oxidative stress due accumulation of reactive oxygen species, shortening and dysfunctionality of telomeres, and the increased expression of genes associated with aging have been shown to contribute to exacerbation of allergic respiratory diseases, such as allergic rhinitis and bronchial asthma ( 10 – 12 ). These findings suggest that targeted therapies must also consider the temporal progression of the allergy.…”

Section: Current Theories On Allergic Diseasesmentioning

confidence: 99%

Immunologic, genetic, and ecological interplay of factors involved in allergic diseases

Falcon

Caoili

2023

Front. Allergy

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An allergic or type I hypersensitivity reaction involves a misdirected immune overreaction to innocuous environmental and dietary antigens called allergens. The genetic predisposition to allergic disease, referred to as atopy, can be expressed as a variety of manifestations—e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, allergic asthma, anaphylaxis. Globally, allergic diseases are one the most common types of chronic conditions. Several factors have been identified to contribute to the pathogenesis and progression of the disease, leading to distinctively variable clinical symptoms. The factors which can attenuate or exacerbate allergic reactions can range from genetic heterozygosity, the prominence of various comorbid infections, and other factors such as pollution, climate, and interactions with other organisms and organism-derived products, and the surrounding environment. As a result, the effective prevention and control of allergies remains to be one of the most prominent public health problems. Therefore, to contextualize the current knowledge about allergic reactions, this review paper attempts to synthesize different aspects of an allergic response to describe its significance in the global health scheme. Specifically, the review shall characterize the biomolecular mechanisms of the pathophysiology of the disease based on underlying disease theories and current findings on ecologic interactions and describe prevention and control strategies being utilized. An integrated perspective that considers the underlying genetic, immunologic, and ecologic aspects of the disease would enable the development of more effective and targeted diagnostic tools and therapeutic strategies for the management and control of allergic diseases.

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Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy

Cited by 7 publications

References 33 publications

WITHDRAWN: Network Pharmacology and Molecular Docking Study of Jinwei Decoction for Enhancement of Glucocorticoid Anti-Inflammatory Effect in COPD through miR-21

WITHDRAWN: Network Pharmacology and Molecular Docking Study of Jinwei Decoction for Enhancement of Glucocorticoid Anti-Inflammatory Effect in COPD through miR-21

Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept

Immunologic, genetic, and ecological interplay of factors involved in allergic diseases

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