Expression of SP and ALP Following the Application of Watermelon Frost in Reversible Pulpitis: An In Vivo Study

Sumawinata, Narlan

doi:10.5005/jp-journals-10015-1717

Cited by 1 publication

(2 citation statements)

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“…Watermelon frost was self-prepared based on the previously reported method with some modifications [14]. The watermelon (4 kg) was cut into two pieces.…”

Section: Preparation Of Wfmentioning

confidence: 99%

“…Previous in vitro research demonstrated that WF decreased prostaglandin E2 expression levels which significantly increased pulp inflammation [13]. Dennis et al suggested that WF is effective in the treatment of reversible pulpitis by increasing alkaline phosphatase concentration and decreasing substance P concentration [14]. In addition, WF also has therapeutic effects against burns and body heat by reducing inflammation levels and promoting healing and repair.…”

Section: Introductionmentioning

confidence: 99%

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Identification and quantification of cucurbitacin in watermelon frost using molecular networking integrated with ultra‐high‐performance liquid chromatography‐tandem mass spectrometry

Liu

2023

J of Separation Science

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Watermelon frost, a traditional Chinese medicine produced using watermelon and Glauber's salt, has been widely used for the therapy of oral and throat disorders. Watermelon contains various phytochemical compounds including cucurbitacins and their glycoside derivatives, which have attracted considerable attention because of their medicinal values. However, whether the composition of cucurbitacins existed in watermelon frost was rarely reported. In this study, three cucurbitacins including cucurbitacin B, isocucurbitacin B, and cucurbitacin E were found from watermelon frost extract assisted by ultra-highperformance liquid chromatography-tandem mass spectrometry and molecular networking guided strategy, and the compounds were verified using standard solutions. Furthermore, a quantification method for simultaneously targeted analysis of cucurbitacins was established using ultra-high-performance liquid chromatography-tandem mass spectrometry operating in the multiple reaction monitoring mode. Among them, cucurbitacin B and cucurbitacin E in watermelon frost samples were determined, and the concentrations were 3.78 ± 0.18 and 0.86 ± 0.19 ng/ml, respectively. While isocucurbitacin B was not detected due to the lower content possibly. In conclusion, ultra-high-performance liquid chromatography-tandem mass spectrometry combined with molecular networking is a very useful technique for the rapid identification of unknown cucurbitacin components in watermelon frost.

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“…Watermelon frost was self-prepared based on the previously reported method with some modifications [14]. The watermelon (4 kg) was cut into two pieces.…”

Section: Preparation Of Wfmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%