Expression of stefin A is of prognostic significance in squamous cell carcinoma of the head and neck

Aničin, Aleksandar; Gale, Nina; Šmid, Lojze; Kos, Janko; Strojan, Primož

doi:10.1007/s00405-013-2465-5

Cited by 14 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(19)(20)(21)(22) Cathepsin B expression in patients with PDAC is related to prognosis and recurrence, (23)(24)(25) although the mechanism remains to be elucidated. Cystatin A expression has been observed in tumor tissues, such as breast, (26) head and neck, (27) and lung (28) cancers, as well as hepatocellular carcinoma. (29) In the current study, cathepsin B was expressed in tumor cells, as well as tumor-infiltrating immune cells, especially macrophages, in PDAC tissues.…”

Section: Discussionmentioning

confidence: 99%

Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma

et al. 2017

View full text Add to dashboard Cite

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy known, with an extremely poor prognosis due to the lack of an efficient diagnostic scheme and no radical treatment option, except surgery. Therefore, understanding the pathophysiology of, and finding a novel biomarker to detect, PDAC should be prioritized. We observed an increase in mRNA expression of the cysteine protease inhibitor cystatin A (CSTA) in CD4+ T cells in peripheral blood cells of nine patients with PDAC, compared with the expression in seven healthy volunteers. Moreover, we confirmed significantly higher CSTA mRNA expression in a larger cohort of 41 patients with PDAC compared with that in 20 healthy volunteers. Correspondingly, the serum CSTA concentrations in 36 patients with PDAC were higher than those in 37 healthy volunteers, and this increase was correlated with PDAC clinical stage. Furthermore, the expression of CSTA and cathepsin B, which is a lysosomal cysteine protease inhibited by CSTA, was observed in tumor tissues and tumor‐infiltrating immune cells in 20 surgically resected PDAC tissues by immunohistochemical staining. Expression of CSTA was detected in some tumor tissues and many tumor‐infiltrating immune cells. Cathepsin B expression was also observed in most tumor tissues and tumor‐infiltrating immune cells. In conclusion, CSTA and its substrate cathepsin B are involved in PDAC‐related inflammation. The increment of CSTA expression in peripheral blood of patients with PDAC may have a potential role as a PDAC immunopathologic biomarker.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In a study of immunohistochemistry for head and neck cancers the levels of cathepsins and stefins A and B were examined (Anicin et al, 2013). Stefin A immunopositivity correlates with a favorable outcome in this study of head and neck cancer.…”

Section: Type I Cystatinsmentioning

confidence: 99%

Cystatins as regulators of cancer

Cox¹

2017

MRAJ

View full text Add to dashboard Cite

show abstract

“…In breast cancer, elevated levels of stefin A were suggested to have an inverse correlation with metastatic potential and clinical prognosis (Parker et al, ). However, in head and neck squamous cell carcinoma (Aničin et al, ), increasing stefin A levels have been demonstrated to be positively correlated with tumor prognosis. The clinical significance of the down‐ and up‐regulated stefin B expression levels have also been indicated in colorectal carcinoma (Koshiyama et al, ), gastric cancer (Song et al, ), esophageal carcinoma (Zhang et al, ) and prostatic adenocarcinoma (Mirtti et al, ).…”

mentioning

confidence: 99%

Tissue Levels of Stefin A and Stefin B in Hepatocellular Carcinoma

Lin

Chen

Zhang

et al. 2016

The Anatomical Record

View full text Add to dashboard Cite

Stefins have been reported to be associated with the progression and metastasis of various malignant tumors. However, the expressions of stefins in hepatocellular carcinoma (HCC) have not been well-defined. In this study, the protein levels of stefin A and stefin B were assessed by immunohistochemical staining, and the mRNA levels were quantified by real-time polymerase chain reaction in 85 primary HCC tissues, 85 surrounding non-cancerous tissues, and 9 normal hepatic tissues. The immunohistochemical staining of cathepsin B and cathepsin D, and the ratio of cathepsins to stefins were assessed. The mRNA expressions of stefin A and stefin B in HCC tissues were significantly higher than surrounding noncancerous tissues and normal hepatic tissues, respectively. A significant positive relationship of stefin A and stefin B was found with node metastasis, tumor size, and Edmondson grade for HCC. Univariate and multivariate analyses revealed that Edmondson grade and stefin B expression were independent factors associated with the risk of lymph node metastasis in HCC. The ratios of cathepsin B to stefin A, cathepsin D to stefin A, cathepsin B to stefin B and cathepsin D to stefin B of the HCC group were significantly higher than that of the surrounding noncancerous group. A significant positive correlation between the ratio of cathepsins to stefins (cathepsin B/stefin A, cathepsin B/stefin B and cathepsin D/stefin B) and node metastasis was demonstrated. We concluded that high expressions of stefin A and stefin B may be an important factor contributing to the development and metastasis of HCC. Anat Rec,

show abstract

Expression of stefin A is of prognostic significance in squamous cell carcinoma of the head and neck

Cited by 14 publications

References 24 publications

Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma

Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma

Cystatins as regulators of cancer

Tissue Levels of Stefin A and Stefin B in Hepatocellular Carcinoma

Contact Info

Product

Resources

About