Expression of stress‐induced phosphoprotein1 (STIP1) is associated with tumor progression and poor prognosis in epithelial ovarian cancer

Abstract

Stress-induced phosphoprotein1 (STIP1) is a candidate biomarker in epithelial ovarian cancer (EOC). In this study, we investigated in detail the expression of STIP1, as well as its functions, in EOC. STIP1 expression was assessed by immunohistochemistry (IHC) and the results were compared with clinicopathologic factors, including survival data. The effects of STIP1 gene silencing via small interfering RNA (siRNA) were examined in EOC cells and a xenograft model. The expression of STIP1 protein in EOC was significantly higher than in the other study groups (P < 0.001), and this increase of expression was significantly associated with tumor stage (P = 0.005), tumor grade (P = 0.029), and lymph node metastasis (P = 0.020). In multivariate analysis, overall survival in EOC was significantly shorter in cases with high STIP1 expression (HR = 2.78 [1.01-7.63], P = 0.047). STIP1 silencing in EOC cells resulted in inhibition of cell proliferation and invasion. In addition, in vivo experiments using STIP1 siRNA clearly showed a strong inhibition of tumor growth and a modulation of expression of prosurvival and apoptotic genes, further suggesting that STIP1 silencing can prevent cell proliferation and invasion. In conclusion, increased STIP1 expression is associated with poor survival outcome in EOC, and STIP1 may represent a useful therapeutic target in EOC patients.

HSP70/HSP90-Organizing Protein Contributes to Gastric Cancer Progression in an Autocrine Fashion and Predicts Poor Survival in Gastric Cancer

“…Patients with higher or positive HOP expression showed a worse prognosis and advanced tumor progression in patients with papillary thyroid carcinoma [29], ovarian cancer [30], HCC [25], and epithelial ovarian cancer [31]. In our study, high HOP protein expression in GC tumors was associated with advanced Bormman classification, differentiated degree, T staging, N staging, M staging, and TNM staging ( Table 1).…”

“…For example, in pancreatic cancer, knockdown of HOP in pancreatic cancer cells decreased cell invasion via downregulation of matrix metalloproteinase 2 (MMP2) [32]. Cho et al [31]. demonstrated that downregulated HOP in epithelial ovarian cancer cells showed strong inhibition of tumor growth and modulation of ID3 and Smad1/Smad5 expression.…”

Novel immunohistochemical markers differentiate intrahepatic cholangiocarcinoma from benign bile duct lesions

“…Increased STIP1 expression in various solid epithelial tumours has been described, including ovarian carcinoma24 and papillary thyroid carcinoma 25. In our study, the expression of STIP1 was significantly higher in ICC than in DRs, whereas the difference to the BDA group was not significant.…”

Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains

“…In an autoimmune myocarditis-induced chronic heart failure rat model HSP-90β was suggested to play a protective role (Sanzen et al 2010). Increased levels of stress-induced phosphoprotein-1 have been associated with cancer (Cho et al 2014). …”