Expression of the antiapoptotic survivin in the adenomatoid odontogenic tumors

El‐Sheikh, Sahar M.; Omar, Taissir A.; Halim, Hasseri; AbdelSattar, M.F.

doi:10.1016/j.tdj.2014.09.003

Cited by 3 publications

(5 citation statements)

References 32 publications

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“…ElSheikh et al . [ 9 ] who used an immunohistochemical technique to examine the expression of survivin in AOT specimens and tooth germ specimens as a control. The reaction was mostly found in duct-like structures and whorled pattern spindle cells.…”

Section: Discussionmentioning

confidence: 99%

“…[ 8 ] As per the majority of reports, Adenomatoid Odontogenic Tumor (AOT) frequently manifests as a slow-growing, painless mass affecting the anterior maxilla, with three clinical subtypes that all have the same histology: follicular type (73%), extra-follicular variant (24%), and peripheral (3%). [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

“…This 16.5 kDa protein belongs to the inhibitor of apoptosis protein (IAP) family, which regulates the cell cycle and suppresses apoptosis. [ 9 ] It has antiapoptotic and promitotic functions and is involved in Bax inhibition. [ 10 ] Survivin is involved in the development and progression of several cancers.…”

Section: Introductionmentioning

confidence: 99%

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Expression of anti - Apoptotic survivin in odontogenic keratocyst, adenomatoid odontogenic tumor and ameloblastoma

Latha,

Prakash,

Kanth

et al. 2023

Journal of Oral and Maxillofacial Pathology

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Background: The process of odontogenesis is complex involving epithelial–mesenchymal interactions, along with the molecular signalling pathways triggering the initiating process. The triggering factors and cells precisely involved in the pathogenesis of odontogenic cysts and tumors are unknown. There is a vast array of biomarkers used to stain different sites, thereby helpful in diagnosing and evaluating the prognosis of these cysts and tumors. In the following study, Anti Apoptotic survivin expression patterns were assessed quantitatively in 48 samples (12 each) of Reduced Enamel Epithelium, Adenomatoid Odontogenic Tumor, Odontogenic Keratocyst and Ameloblastoma. Aim: The Aim of this study is to assess the anti-apoptotic survivin expression in Reduced Enamel Epithelium, Adenomatoid odontogenic tumour, Odontogenic Keratocyst and Ameloblastoma. Materials and Methods: The present study is carried out with 12 samples in each group. Routine hematoxylin and eosin staining was performed for confirmatory diagnosis. Later Immunohistochemistry was performed using survivin antibody. Survivin protein expression was analyzed using the parameters like location, intensity, percentage of cells positivity with survivin protein and extent of staining. With the help of Olympus BX 43 microscope, with ProgRes microscope camera, the 48 slides obtained were examined. The region of interest was selected in each slide and number of cells positively stained was counted. Data was analyzed using SPSS software version 23. Descriptive for scale data, results were analysed by using ANOVA with Chi-square test for intergroup comparison. Results: The results showed significant P value <0.05. Expression of survivin was highest in Ameloblastoma, followed by Odontogenic keratocyst, Adenomatoid odontogenic tumor, and Reduced Enamel Epithelium. Conclusion: Survivin was involved in the inhibition of apoptosis as well as the detailed understanding of the biological behaviour of odontogenic cysts and tumours, thereby increasing therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression of anti - Apoptotic survivin in odontogenic keratocyst, adenomatoid odontogenic tumor and ameloblastoma

Latha,

Prakash,

Kanth

et al. 2023

Journal of Oral and Maxillofacial Pathology

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“…Moreover, these authors also demonstrated that while the lymph node involvement increased,thesurvivaldecreased,regardlessofthesize oftumor;and,onthecontrary,assizeoftumorincreased, the survival status decreased, regardless of thelymphnodeinvolvement.However,therelation between the size of tumor and the lymph nodes in breastcancerwasbeyondthescopeofourstudy.Instead,wewereinterestedintherelationbetweenthe lymphnodestatusandthesubcellularlocalizationof survivinand,asaresult,wedidnotconfirmanysignificantcorrelation. [53,54].…”

Section: Discussionmentioning

confidence: 99%

Survivin in breast lesions: immunohistochemical analysis of 196 cases

Adamkov¹,

Drahošová²,

Chylíková³

et al. 2017

pjp

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Weexaminedthesurvivinexpressionpatternbyimmunohistochemistryin43fi-broadenomasand153ductalcarcinomasofthebreast.Thesubcellularlocalization ofsurvivin andtheintensityofimmunoreactionwereassessed.We analyzedthe differencesofsurvivinexpressionbetweenfibroadenomasandcarcinomas.Wealso correlatedthesurvivinexpressionpatternincarcinomaswithotherclinicomorphologicalparameterssuchastheageofpatients,thegradeandsizeofprimarytumor aswellasthelymphnodemetastasis.Overall,survivinwasdetectedin107/153 carcinomas(69.9%)andin26/43fibroadenomas(60.5%).Statisticalanalysisconfirmedsignificantcorrelationsbetweentheassessedparametersinfibroadenomas andcarcinomas.Gradeofcarcinomaswassignificantlyrelatedtosurvivinexpressioninbothsubcellularlocalizationandtheintensityofimmunoreaction.Tumor grade3wasassociatedwithnuclearpositivityandcombinednuclearandcytoplas-mic localization. Carcinomas larger than 20 mm showed nuclear and combined localizationin81%ofcasesandhigherintensityofsurvivinimmunoreactionwas alsonotablyrelatedtolargercarcinomas.Statisticallysignificantdifferenceswere alsoobservedbetweensubcellularsurvivinlocalizationandintensityofimmunoreaction.Ourresultsuggestthatnuclearaccumulationofsurvivinisassociatedwith proliferativefenotypeandsurvivinwasshowntobeaworseprognosticmarkerin breastductalcarcinoma.

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“…Apart from tumours, the protein is highly expressed in embryonic and foetal tissues, but is completely absent in terminally differentiated adult cells (Chang et al, 2004;Lechler et al, 2007;Xue et al, 2012;Jaiswal et al, 2015). The survivin expression in embryonic and foetal development contributes to tissue homeostasis and differentiation (Adida et al, 1998;ElSheikh et al, 2014). Survivin expression is highly regulated by the cell cycle and the protein is only expressed in the G2-M phase (Altieri, 2008;Jaiswal et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Sequence Characterization of Baculoviral Inhibitor of Apoptosis Repeat Containing 5 (BIRC 5) Gene from a Case of Canine Mammary Tumour

Jena¹,

Saxena²,

Shrivastav³

et al. 2015

Asian J. of Animal and Veterinary Advances

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The BIRC 5 (also called survivin), member of the inhibitor of apoptosis protein family is highly over-expressed in human and animal cancers leading to poor prognosis. Still there is limited information about the gene sequence in dogs suffering with canine mammary tumour. Therefore, the present study was undertaken to find out any correlation of BIRC 5 gene over-expression with mutation status of the gene. The CMT tissues were confirmed by histopathological examination and included cases of mixed myoepithelioma, complex adenocarcinoma, mixed mammary capillary cystic adenocarcinoma and invasive solid carcinoma etc. Quantitative Real Time PCR (qRT-PCR) revealed 5.6±0.462-60.0±1.476 fold higher BIRC 5 gene expression levels in CMT tissues as compared to dog normal mammary gland tissues. The coding region of the gene was amplified, cloned and sequenced from a case of complex mammary carcinoma showing approximately 60.0±1.476 fold amplification of BIRC 5 gene. The sequence showed 100% similarity with the mRNA sequences of normal dog BIRC 5 present in NCBI. This indicates that BIRC 5 gene sequence in healthy dogs is similar to dogs suffering from CMT and showing over-expression of the gene. The multiple sequence alignment of the survivin gene with other species like cat, cow, buffalo, sheep, goat and human etc. revealed more than 90% similarity. The phylogenetic analysis demonstrates that gene is highly conserved across species to maintain its functional integrity. The findings revealed that there is no sequence alteration in BIRC 5 gene sequence in the CMT tissue showing more than 60 fold over-expression of the gene.

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Expression of the antiapoptotic survivin in the adenomatoid odontogenic tumors

Cited by 3 publications

References 32 publications

Expression of anti - Apoptotic survivin in odontogenic keratocyst, adenomatoid odontogenic tumor and ameloblastoma

Expression of anti - Apoptotic survivin in odontogenic keratocyst, adenomatoid odontogenic tumor and ameloblastoma

Survivin in breast lesions: immunohistochemical analysis of 196 cases

Sequence Characterization of Baculoviral Inhibitor of Apoptosis Repeat Containing 5 (BIRC 5) Gene from a Case of Canine Mammary Tumour

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