Expression of the arylhydrocarbon receptor in the peri-implantation period of the mouse uterus and the impact of dioxin on mouse implantation

Kitajima, Michio; Khan, Khaleque Newaz; Fujishita, Akira; Masuzaki, Hiroaki; Koji, Takehiko; Ishimaru, Tadayuki

doi:10.1679/aohc.67.465

Cited by 35 publications

(33 citation statements)

References 30 publications

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“…AhR-deficient mice are resistant to BaP-induced carcinogenicity (71) and dioxin toxicity (15,33) and exhibit cardiac hypertrophy, reduced fecundity, and postnatal growth retardation independent of exogenous ligand (70,78). AhR expression has been previously demonstrated in the mouse uterus and fetal endothelium of the mouse placenta (51).…”

mentioning

confidence: 97%

Fetal growth restriction triggered by polycyclic aromatic hydrocarbons is associated with altered placental vasculature and AhR-dependent changes in cell death

Detmar¹,

Rennie²,

Whiteley³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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mentioning

confidence: 97%

Fetal growth restriction triggered by polycyclic aromatic hydrocarbons is associated with altered placental vasculature and AhR-dependent changes in cell death

Detmar¹,

Rennie²,

Whiteley³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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“…Expression of AhR protein and mRNA has also been reported in mouse and rabbit placentas (Tscheudschilsuren et al 1999;Kitajima et al 2004) and in a variety of mouse fetal tissues, e.g., liver, lung, and kidney in gestational days 12-16 (Abbott et al 1995). However, information on AhR protein expression and cellular distribution in human placentas from N and preeclamptic (PE) pregnancies, as well as in the developing fetus, is lacking.…”

mentioning

confidence: 98%

Expression of Aryl Hydrocarbon Receptor in Human Placentas and Fetal Tissues

Jiang

Wang

Fang

et al. 2010

J Histochem Cytochem.

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The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, mediates many biological processes, including fetal development. In this study, we examined AhR protein expression in human placentas from normal (N) and severe preeclamptic (sPE) pregnancies, as well as human fetal tissues from the second trimester of pregnancy, using immunohistochemistry and/or Western blot analysis. In the placentas, the AhR immuno-reactivity was present primarily in syncytiotrophoblasts. The AhR staining was also seen in endothelium of large blood vessels in villi and endothelium of umbilical cord arteries and veins. No difference in AhR protein levels was found between N and sPE placentas. In fetal tissues, the AhR immunoreactivity was localized in lung, kidney, esophagus, pancreas, liver, testicle, thymus gland, retina, and choroid, mainly in epithelial cells, whereas it was absent in heart, brain, sclera, and thoracic aorta. These findings suggest that the AhR plays a critical role in syncytiotrophoblasts of human placentas and epithelium of many fetal organs. These data also imply that human placentas and those fetal organs with high AhR expression (e.g., lung, kidney, liver, pancreas, and thymus gland) during fetal development are highly susceptible to environmental toxicants such as dioxin.

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“…No physiological role for this phenomenon has yet been demonstrated, although a further relationship with estradiol metabolism would not be unlikely. After implantation, the AHR is strongly expressed in the uterine vasculature and developing tissues between the embryo and dam (Kitajima et al, 2004). The absence of AHR signaling in these tissues has been shown to result in an enlarged placental labyrinth with altered dam-to-pup filtration (Thomae et al, 2004;T.…”

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confidence: 99%

The Aryl Hydrocarbon Receptor sans Xenobiotics: Endogenous Function in Genetic Model Systems

McMillan

Bradfield

2007

Molecular Pharmacology

156

131

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For more than 30 years, the aryl hydrocarbon receptor [Ah receptor (AHR)] has been extensively scrutinized as the cellular receptor for numerous environmental contaminants, including polychlorinated dioxins, dibenzofurans, and biphenyls. Recent evidence argues that this description is incomplete and perhaps myopic. Ah receptor orthologs have been demonstrated to mediate diverse endogenous functions in our close vertebrate relatives as well as our distant invertebrate ancestors. Moreover, these endogenous functions suggest that xenobiotic toxicity may be best understood in the context of intrinsic AHR physiology. In this literature review, we survey the emerging picture of endogenous AHR biology from work in the vertebrate and invertebrate model systems Mus musculus, Caenorhabditis elegans, and Drosophila melanogaster.

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Expression of the arylhydrocarbon receptor in the peri-implantation period of the mouse uterus and the impact of dioxin on mouse implantation

Cited by 35 publications

References 30 publications

Fetal growth restriction triggered by polycyclic aromatic hydrocarbons is associated with altered placental vasculature and AhR-dependent changes in cell death

Fetal growth restriction triggered by polycyclic aromatic hydrocarbons is associated with altered placental vasculature and AhR-dependent changes in cell death

Expression of Aryl Hydrocarbon Receptor in Human Placentas and Fetal Tissues

The Aryl Hydrocarbon Receptor sans Xenobiotics: Endogenous Function in Genetic Model Systems

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