Expression of the cutaneous lymphocyte antigen and its counter-receptor E-selectin in the skin and joints of patients with psoriatic arthritis.

Jones, Stephanie; Dixey, J.; Hall, N. D.; McHugh, Neil

doi:10.1093/rheumatology/36.7.748

Cited by 34 publications

(26 citation statements)

References 20 publications

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“…The concept of the relationship between psoriasis and PsA has been largely based on the current view of PsA as primarily a synovial and skin disease mediated by preferential homing of immune cells to these sites (29,53). However, experimental evidence, in addition to clinical and imaging data, now suggests that enthesitis may be the primary skeletal lesion.…”

Section: The Relationship Between Skin and Joint Diseasementioning

confidence: 99%

Psoriatic arthritis: A unified concept twenty years on

McGonagle

Conaghan

Emery

1999

Arthritis & Rheumatism

263

137

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Section: The Relationship Between Skin and Joint Diseasementioning

confidence: 99%

Psoriatic arthritis: A unified concept twenty years on

McGonagle

Conaghan

Emery

1999

Arthritis & Rheumatism

263

137

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“…36 This has led to the proposal (especially in the case of psoriatic arthritis) that attraction of cutaneous lymphocytes to the synovium may be a component of the disease mechanism. 36 Our findings demonstrate that lymphocytes from synovial fluid do indeed contain cells of the cutaneous homing phenotype, but cells of intestinal and other homing phenotypes are present as well. Thus, cutaneous lymphocytes are not enriched in the synovial fluid above their relative numbers in normal peripheral blood.…”

Section: Ccr4 Expression Levels and Functionmentioning

confidence: 99%

Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-Infiltrating Lymphocytes

Kunkel

Boisvert

Murphy

et al. 2002

The American Journal of Pathology

225

178

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Differential expression of adhesion molecules and chemokine receptors has been useful for identification of peripheral blood memory lymphocyte subsets with distinct tissue and microenvironmental tropisms. Expression of CCR4 by circulating memory CD4 ؉ lymphocytes is associated with cutaneous and other systemic populations while expression of CCR9 is associated with a small intestine-homing subset. CCR5 and CXCR3 are also expressed by discrete memory CD4؉ populations in blood, as well as by tissueinfiltrating lymphocytes from a number of sites. To characterize the similarities and differences among tissue-infiltrating lymphocytes, and to shed light on the specialization of lymphocyte subsets that mediate inflammation and immune surveillance in particular tissues, we have examined the expression of CCR4, CXCR3, and CCR5 on CD4؉ lymphocytes directly isolated from a wide variety of normal and inflamed tissues. Extra-lymphoid tissues contained only memory lymphocytes, many of which were activated (CD69 ؉ ). As predicted by classical studies, skin lymphocytes were enriched in CLA expression whereas intestinal lymphocytes were enriched in ␣ 4 ␤ 7 expression. CCR4 was expressed at high levels by skin-infiltrating lymphocytes, at lower levels by lung and synovial fluid lymphocytes, but never by intestinal lymphocytes. Only the high CCR4 levels characteristic of skin lymphocytes were associated with robust chemotactic and adhesive responses to TARC, consistent with a selective role for CCR4 in skin lymphocyte homing. In contrast, CXCR3 and CCR5 were present on the majority of lymphocytes from each non-lymphoid tissue examined, suggesting that these receptors are unlikely to determine tissue specificity, but rather, may play a wider role in tissue inflammation.

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“…We and other investigators have previously reported microscopic features of the synovial membrane (SM), relating mainly to the vasculature and lining layer, that suggest differences between PsA and RA (3)(4)(5)(6)(7). Macroscopically, SM inflammation manifests as capillary hyperemia (redness), increased vascularity (blood vessel markings), granularity, or villous formation (hypertrophy), while proliferating SM or pannus adheres to and erodes the chondral surface.…”

mentioning

confidence: 94%