Expression of the CXCL12/SDF-1 Chemokine Receptor CXCR7 in Human Brain Tumours

Tang, Tian; Xia, Qingjie; Chen, Jianbin; Xi, Mingrong; Liu, Ding

doi:10.7314/apjcp.2012.13.10.5281

Cited by 13 publications

(17 citation statements)

References 39 publications

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“…Barbieri et al have claimed that meningioma tissues express a number of receptors such as CXCR1, CXCR2, CXCR3, CXCR4, and CXCR5 among which CXCR4 had a mitogenic activity through ERK1/2 signalling pathway (Barbieri et al, 2006). CXCR7 mRNA was also detected in tumor samples from patients with neurilemmoma, pituitary adenoma, hemangioblastoma, and meningioma but the level of expression was significantly higher in neurilemmoma and meningioma compared to tissues from pituitary adenoma and hemangioblastoma (Tang et al, 2012).…”

Section: Discussionmentioning

confidence: 87%

Expression of Chemokines and Chemokine Receptors in Brain Tumor Tissue Derived Cells

Razmkhah

Arabpour²,

Taghipour³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Chemokine and chemokine receptor expression by tumor cells contributes to tumor growth and angiogenesis and thus these factors may be considered as tumor markers. Here we aimed to characterize cells directly extracted from glioma, meningioma, and secondary brain tumors as well as non-tumoral cells in vitro. Cells were isolated from brain tissues using 0.2% collagenase and characterized by flow cytometry. Expression of SDF-1, CXCR4, CXCR7, RANTES, CCR5, MCP-1 and IP-10 was defined using flow cytometry and qRT-PCR methods. Brain tissue isolated cells were observed as spindle-shaped cell populations. No significant differences were observed for expression of SDF-1, CXCR4, CXCR7, RANTES, CCR5, and IP-10 transcripts. However, the expression of CXCR4 was approximately 13-fold and 110-fold higher than its counterpart, CXCR7, in meningioma and glioma cells, respectively. CXCR7 was not detectable in secondary tumors but CXCR4 was expressed. In non tumoral cells, CXCR7 had 1.3-fold higher mRNA expression than CXCR4. Flow cytometry analyses of RANTES, MCP-1, IP-10, CCR5 and CXCR4 expression showed no significant difference between low and high grade gliomas. Differential expression of CXCR4 and CXCR7 in brain tumors derived cells compared to non-tumoral samples may have crucial impacts on therapeutic interventions targeting the SDF-1/CXCR4/CXCR7 axis.

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Section: Discussionmentioning

confidence: 87%

Expression of Chemokines and Chemokine Receptors in Brain Tumor Tissue Derived Cells

Razmkhah

Arabpour²,

Taghipour³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…ASCs are also CXCR4‐positive cells representing an additional target for SDF‐1 induced homing . Recently, a new SDF‐1 receptor named CXCR7 was identified on EPC, bone marrow‐derived MSCs, and in cancer cells of different origin, like ovarian, thyroid, and brain . In the latter, it plays an important role in tumor angiogenesis and metastatic dissemination.…”

mentioning

confidence: 99%

The role of SDF‐1 in homing of human adipose‐derived stem cells

Lipenksy

Thamm

Neugebauer

et al. 2015

Wound Repair Regeneration

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One of the putative pathophysiological mechanisms of chronic wounds is a disturbed homing of stem cells. In this project, the stromal cell-derived factor 1 (SDF-1)/C-X-C chemokine receptor (CXCR) 4 and SDF-1/CXCR7 pathway were focused in human adipose-derived stem cells (ASCs). ASCs were incubated with acute (AWF) or chronic wound fluid (CWF) to analyze their effects by quantitative real-time polymerase chain reaction (SDF-1, CXCR4, CXCR7, TIMP3), enzyme-linked immunosorbent assay (SDF-1 in WFs and supernatant), and transwell migration assay with/without antagonization. Whereas SDF-1 amounted 73.5 pg/mL in AWF, it could not be detected in CWF. Incubation with AWF led to a significant enhancement (129.7 pg/mL vs. 95.5 pg/mL), whereas CWF resulted in a significant reduction (30 pg/mL vs. 95.5 pg/mL) of SDF-1 in ASC supernatant. The SDF-1 receptor CXCR7 was detected on ASCs. AWF but not CWF significantly induced ASC migration, which was inhibited by CXCR4 and CXCR7 antagonists. Expressions of SDF-1, CXCR4, and CXCR7 were significantly stimulated by AWF while TIMP3 expression was reduced. In conclusion, an uncontrolled inflammation in the chronic wound environment, indicated by a reduced SDF-1 expression, resulted in a decreased ASC migration. A disturbed SDF-1/CXCR4 as well as SDF-1/CXCR7 pathway seems to play an important role in the impaired healing of chronic wounds.

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“…(4) Our findings in the present study suggested that CXCR7 was also ubiquitously expressed in otorhinolaryngologic tumours, further 16.00…”

Section: Discussionmentioning

confidence: 49%

“…In vivo and in vitro investigations have demonstrated that CXCR7 is widely distributed in neoplasms such as lung and cervical cancer, and brain tumour tissues; (3)(4)(5) furthermore, a higher level of expression of CXCR7 is linked to an early recurrence rate as well as a lower five-year disease-free survival rate in lung cancer patients. (3) The molecular mechanism of CXCR7 signalling acts through the enhancement of environmental tolerance and proliferation of tumour cells.…”

Section: Introductionmentioning

confidence: 99%