Expression of the estrogen receptor in human thyroid neoplasms

Yane, Katsunari; Kitahori, Yoshiteru; Konishi, Noboru; Okaichi, Kunio; Ohnishi, Takeo; Miyata, Hiroshi; Matsunaga, Takashi; Lin, Jung-Chung; Hiasa, Yoshio

doi:10.1016/0304-3835(94)90358-1

Cited by 76 publications

(69 citation statements)

References 22 publications

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“…On the other hand, it is conceivable that E 2 may affect thyroid function directly. Estrogen receptors are present in both normal and neoplastic thyroid tissues (18,19). Although estrogen modulates growth of the thyroid gland (20), which may partly be mediated through its effect on iodide uptake by thyroid follicular cells (21), the lack of change in thyroid hormones after administration of gonadotropins to humans (22) and estrogen to animals (23) makes a direct influence of estrogen on the production and secretion of thyroid hormones less likely.…”

Section: Discussionmentioning

confidence: 99%

The relationship between circulating estradiol and thyroid autoimmunity in males

Chailurkit¹,

Aekplakorn

Ongphiphadhanakul

2014

European Journal of Endocrinology

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Introduction: Although autoimmune thyroid disease is less common in males, it is unclear whether estrogen contributes to the difference in susceptibility among males. Objective: To examine whether circulating estradiol (E 2 ) is related to thyroid autoimmunity in males. Patients and methods: One-thousand two-hundred and sixty-three males aged 15-94 years were studied. Serum levels of E 2 , TSH receptor antibody (TRAb), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), free thyroxine (FT 4 ), and TSH were measured by ELISA. Results: Circulating E 2 varied widely in males, ranging 18.4-403.7 pmol/l with a mean value of 136.2G51.7 pmol/l. E 2 increased with age (rZ0.18, P!0.001). No relationship between E 2 and BMI was found. When comparing the difference in E 2 according to the test results of TRAb, TPOAb, and TgAb, it was found that E 2 was significantly higher in subjects with positive TRAb (TRAb positive, E 2 Z170.3G59.8 pmol/l; TRAb negative, E 2 Z134.0G50.6 pmol/l; P!0.001). No difference in E 2 was demonstrated according to the results of TPOAb or TgAb. Logistic regression analysis showed that E 2 was a determinant of positive TRAb, independent of age and BMI. There was no relationship between serum E 2 and TSH or FT 4 . However, E 2 was negatively related to TSH (rZK0.45, P!0.01) in subjects whose TSH levels fell below the reference range (0.3-4.2 mIU/l).

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Section: Discussionmentioning

confidence: 99%

The relationship between circulating estradiol and thyroid autoimmunity in males

Chailurkit¹,

Aekplakorn

Ongphiphadhanakul

2014

European Journal of Endocrinology

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“…Differences in experimental period and dosage may account for the differences from the results reported by Komulainen et al 45) Estrogen receptor (ER) has been identified as a principal cellular target for estrogenic compounds 46) and there is also some evidence for ER-regulated gene transcription in vitro 47) and in vivo. 48) It has been reported that normal and tumor thyroid cells have ERs, 49,50) and estradiol might promote thyroid tumorigenesis through receptor binding. 4,5) However, studies on ER expression have failed to provide clear insight into its potential role in thyroid tumor progression.…”

Section: Discussionmentioning

confidence: 99%

Lack of Modifying Effects of Environmental Estrogenic Compounds on the Development of Thyroid Proliferative Lesions in Male Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine (DHPN)

Son

Nishikawa

Ikeda

et al. 2000

Japanese Journal of Cancer Research

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“…Cellular changes/diffuse 100 100 100 100 100 100 100 100 100 100 Hyperplasia/diffuse 100 Atrophy 100 100 100 100 100 100 100 -100 100 Vagina Keratinization/epithelium -------100 --Brain --------- ERs, 32,33) and estradiol might promote thyroid tumorigenesis through receptor binding. 7,28) However, studies on ER expression have failed to provide clear insight into its potential role in thyroid tumor progression.…”

Section: Discussionmentioning

confidence: 99%

Lack of Modification by Environmental Estrogenic Compounds of Thyroid Carcinogenesis in Ovariectomized Rats Pretreated with N‐bis(2‐hydroxypropyl)nitrosamine (DHPN)

Son

Nishikawa

Ikeda

et al. 2000

Japanese Journal of Cancer Research

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The effects of environmental estrogenic compounds, soy isoflavone mixture (SI), genistein (GEN), and nonylphenol (NP), and the possible goitrogen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), on thyroid carcinogenesis were investigated in ovariectomized (OVX) female rats. Five-week-old OVX F344 rats were given a single subcutaneous injection of N-bis(2-hydroxypropyl)nitrosamine (DHPN; 2400 mg/kg, body weight) or vehicle alone. Starting 1 week later, GEN (250 or 25 ppm in diet), SI (400 ppm in diet), NP (250 or 25 ppm in diet), MX (30 ppm, in drinking water), sulfadimethoxine (SDM), a known thyroid tumor-promoter (1000 ppm in drinking water), or β β β β-estradiol 3-benzoate (EB), a synthetic estrogen (0.5 mg in cholesterol pellet, s.c.) were administered for 12 weeks. SDM and EB were included as positive controls. At sacrifice the major organs including the thyroid, pituitary, liver, kidney, uterus, vagina, brain and pancreas were collected and histopathological observation was performed. Thyroid weights were significantly increased (P < < < <0.001) only in the SDM treatment group and pituitary weights were elevated with SDM (P < < < <0.05) and EB (P < < < <0.001). Kidney and uterus weights were also significantly increased (P < < < <0.05)by EB. Histopathologically, proliferative lesions of the thyroid were only observed in the SDM treatment group and of the pituitary in the SDM or EB treatment groups. Renal tubule lesions, uterine squamous metaplasia, vaginal keratinization and telangiectasia of pancreatic islets were also observed with EB. There were no organ weight changes or histopathological lesions in the major organs, including the thyroid, in the GEN, SI, MX or NP treatment groups. Our results thus indicated a lack of modifying effects on thyroid carcinogenesis in female OVX rats, in agreement with our previous finding in males.

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Expression of the estrogen receptor in human thyroid neoplasms

Cited by 76 publications

References 22 publications

The relationship between circulating estradiol and thyroid autoimmunity in males

The relationship between circulating estradiol and thyroid autoimmunity in males

Lack of Modifying Effects of Environmental Estrogenic Compounds on the Development of Thyroid Proliferative Lesions in Male Rats Pretreated with N‐Bis(2‐hydroxypropyl)nitrosamine (DHPN)

Lack of Modification by Environmental Estrogenic Compounds of Thyroid Carcinogenesis in Ovariectomized Rats Pretreated with N‐bis(2‐hydroxypropyl)nitrosamine (DHPN)

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