Expression of the estrogen receptor β in 37 surgically treated pulmonary sclerosing hemangiomas in comparison with non–small cell lung carcinomas

Wu, Chen-Tu; Chang, Yih‐Leong; Lee, Yung-Chie

doi:10.1016/j.humpath.2005.08.003

Cited by 28 publications

(17 citation statements)

References 26 publications

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“…Сведения о содержании ЭРα в опухолевой ткани НМРЛ противоречивы: по разным данным, ЭРα-позитивными являются от 0 до 75% опухолей [7,10,13,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37].…”

Section: экспрессия эстрогеновых рецепторов в ткани немелкоклеточногоunclassified

Estrogen Receptors Β — New Target in Cellular Lung Cancer Treatment

et al. 2012

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Section: экспрессия эстрогеновых рецепторов в ткани немелкоклеточногоunclassified

Estrogen Receptors Β — New Target in Cellular Lung Cancer Treatment

et al. 2012

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“…Immunohistochemical data analysis. Friedenreich antigen and CD44v6, have shown that PSH is an epithelial neoplasm derived from type II pneumocyte (3,7,8). Because of the rareness of PSH, most studies on it have been case reports, with few being conducted at the genetic level.…”

Section: Discussionmentioning

confidence: 99%

“…It cleaves gelatins, is thought to be involved in matrix remodeling and cell migration, and plays a very important role in cancer development and metastasis. In 2005, Wu et al showed that the expression of estrogen receptor ß was increased in PSH (8). Interestingly, it was also reported that estrogen receptor ß increased the invasiveness of breast cancer both in vivo and in vitro through the up-regulation of MMP-9 (13).…”

Section: Discussionmentioning

confidence: 99%

“…It is therefore thought that the nature of this tumor is between benign and malignant. The markers of type II pneumocytes, such as thyroid transcription factor 1 (TTF-1), mucin 1 (MUC1), Thomsen-Friedenreich antigen and CD44v6, showed a significant immunostaining pattern (4,6,7) and the ER-ß receptor expression was also increased in PSH (8), although the biological functions of these genes in terms of the pathology of the tumor are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Increased expression of matrix metalloproteinase 9 and tubulin-α in pulmonary sclerosing hemangioma

Cho

Jin²,

Kim

et al. 2007

Oncol Rep

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Abstract. Pulmonary sclerosing hemangioma (PSH) is relatively rare and is usually considered a benign tumor because of its slow growth and solitary characteristics. However, several cases with lymph node metastasis have been reported, and its pathogenesis has not been fully elucidated. Three sets of PSH specimens from the Korea Lung Tissue Bank, obtained with IRB approval, were analyzed through the construction of an oligo-microarray that contained about 32,000 genes. The resulting data were confirmed by real-time RT-PCR. Protein expression levels were checked by performing immunohistochemistry (IHC) and immunoblot analysis. In the 3 specimens of PSH tissues, 72 of the 32,000 genes were commonly found up-regulated and 290 were commonly found down-regulated as compared to non-tumor tissues from each patient. Paraffin-embedded tissues from 11 cases were used to confirm the expression of matrix metalloproteinase 9 (MMP-9) and tubulin-α proteins in the non-tumor and PSH tissues via IHC. In addition, the upregulation of protein expression was confirmed by immunoblot analysis. As expected, in all cases MMP-9 and tubulin-α were expressed at significantly higher levels in the PSH than in the non-tumor tissues. This is the first report on a study of the whole genome of PSH. Increased expression of MMP-9 could induce the metastatic ability of PSH and tubulin-α might be responsible for the sclerotic character of this disease. The results of this study will be useful in helping to understand and effectively manage patients suffering from PSH.

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“…Although there have been many theories on the histological origin of pulmonary sclerosing hemangioma, most researchers now consider pulmonary sclerosing hemangioma a real tumor that originates from primitive respiratory epithelium. [5][6][7][8][9][10] Pulmon-ary sclerosing hemangioma tissue contains many kinds of cells, mainly interstitial polygonal cells and cuboidal cells lining the surface of the papilla and the inner lacuna, which have clear morphological differences. [11][12][13][14][15] Niho et al performed clonality analysis on both cell types using microdissection and showed that the two cell types exhibited a uniform pattern of monoclonality.…”

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confidence: 99%

Gene expression and clonality analysis of the androgen receptor and phosphoglycerate kinase genes in polygonal cells and cuboidal cells in so-called pulmonary sclerosing hemangioma

Wang

Dai

et al. 2007

Modern Pathology

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The histogenesis of polygonal cells and cuboidal cells in so-called pulmonary sclerosing hemangioma remains unclear. To understand their histogenesis, polygonal and cuboidal cells were obtained from pulmonary sclerosing hemangioma tissue using a laser capture microdissection technique. Genomic DNA and total RNA were extracted and mRNA levels of cytokeratin, epithelial membrane antigen, vimentin, surfactant protein B, thyroid transcription factor-1, synaptophysin, and chromogranin-A were analyzed by RT-PCR. DNA was digested with the methylation-sensitive enzymes HhaI or HpaII, followed by nested PCR of the androgen receptor and phosphoglycerate kinase genes. Samples with polymorphisms were identified and a clonality analysis was performed. The cytokeratin, epithelial membrane antigen, and surfactant protein B genes were clearly expressed in cuboidal cells, while the vimentin and synaptophysin genes were clearly expressed and the epithelial membrane antigen gene was weakly expressed in polygonal cells. Thyroid transcription factor-1 was expressed in both cell types, while neither cell type expressed chromogranin-A. Clonality analysis showed the same loss of allele in both cell types (clonality ratio ¼ 0) or an unbalanced methylation pattern (clonality ratio o0.25). Polygonal and cuboidal cells in pulmonary sclerosing hemangioma exhibited a uniform pattern of monoclonality, indicating that both cell types are highly likely to originate from a common precursor. The differences in their morphological phenotype might result from their different mature status.

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Expression of the estrogen receptor β in 37 surgically treated pulmonary sclerosing hemangiomas in comparison with non–small cell lung carcinomas

Cited by 28 publications

References 26 publications

Estrogen Receptors Β — New Target in Cellular Lung Cancer Treatment

Estrogen Receptors Β — New Target in Cellular Lung Cancer Treatment

Increased expression of matrix metalloproteinase 9 and tubulin-α in pulmonary sclerosing hemangioma

Gene expression and clonality analysis of the androgen receptor and phosphoglycerate kinase genes in polygonal cells and cuboidal cells in so-called pulmonary sclerosing hemangioma

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