2006
DOI: 10.1016/j.neuroscience.2005.12.044
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Expression of the kidney injury molecule 1 in the rat cochlea and induction by cisplatin

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Cited by 74 publications
(68 citation statements)
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“…In CD/1 mice, age-related hearing loss in is associated with ROS formation leading to HIF-1α induction in the cochlea [185]. Nox3 in the inner ear is induced by cisplatin, suggesting that it could mediate the ototoxic effects of this chemotherapeutic agent [182,186].…”
Section: B Nox3 Ototoxicity and Deafnessmentioning
confidence: 99%
“…In CD/1 mice, age-related hearing loss in is associated with ROS formation leading to HIF-1α induction in the cochlea [185]. Nox3 in the inner ear is induced by cisplatin, suggesting that it could mediate the ototoxic effects of this chemotherapeutic agent [182,186].…”
Section: B Nox3 Ototoxicity and Deafnessmentioning
confidence: 99%
“…Therefore, there is a high level of interest in understanding the physiological functions of these enzymes and their potential roles in pathophysiological events (Quinn et al, 2006). Of note, recently, it has been reported that superoxide-generating NADPH oxidase isoform NOX3 was expressed in the organ of Corti of the cochleae (Bánfi et al, 2004;Mukherjea et al, 2006) and vestibular system (Paffenholz et al, 2004). Bánfi et al also demonstrated that NOX3-dependent superoxide production was markedly enhanced after cisplatin exposure to NOX3-transfected human embryonic kidney 293 cells (Bánfi et al, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Thus, there is a clear need for the development of a minimally invasive route of delivery of protective agents to the cochlea to reduce any potential side effects. Recent studies have identified the NOX3 isoform of NADPH oxidase as the main source of ROS generation utilized by cisplatin in the cochlea (2,22). NOX3 appears to manifest some of its cytotoxicity through activation and induction of transient receptor potential vanilloid 1 (TRPV1) channel.…”
mentioning
confidence: 99%