Expression of the NK-1 receptor on islet cells and invading immune cells in the non-obese diabetic mouse

Monosodium glutamate (MSG): A villain and promoter of liver inflammation and dysplasia

“…Taken together, these two observations suggest the intriguing hypothesis that this common dietary constituent might have an important role in the ongoing epidemic of obesity and associated conditions in children [13], particularly when the exposure takes place during the early stages of development. The data also suggest that MSG could have a significant impact in genetic susceptibility models of autoimmunity [14,15] with a subsequent skewing towards a more pro-inflammatory adverse outcome.…”

A role for the substance P/NK‐1 receptor complex in cell proliferation and apoptosis in oral lichen planus

“…SP can also stimulate cell proliferation via transactivation of the epidermal growth factor receptor (EGFR) (Koon et al , 2004). SP is also found in affected tissue in multiple autoimmune diseases, such as Crohn’s disease, rheumatoid arthritis and diabetes (Sakai et al , 1998; Goode et al , 2000; Persson‐Sjögren et al , 2005). Besides the injured tissue, SP and NK‐1R are expressed in infiltrating leucocytes in these diseases, indicating that leucocyte expression of these molecules may also be critical for their development (Persson‐Sjögren et al , 2005).…”

Leptin induces inflammation-related genes in RINm5F insulinoma cells

“…RINm5F cells have previously been described to express Tac1 and to secrete substance P [47]. Interestingly, substance P has recently been implicated in the autoimmune diabetes of the NOD mouse model, because expression of the receptor for substance P (NK-1 receptor) was upregulated in the islets during development of insulitis [48]. However, preprotachykinin has been reported to be expressed in rat pancreatic islets only transiently during development, and the expression in RINm5F cells may reflect embryonal characteristics of this cell line [49].…”