Expression of the onconeural CV2/CRMP5 antigen in thymus and thymoma

Camdessanché, Jean‐Philippe; Lassablière, François; Meyronnet, David; Férraud, Karine; Absi, Léna; Honnorat, Jérôme; Antoine, Jean‐Christophe

doi:10.1016/j.jneuroim.2006.01.018

Cited by 21 publications

(10 citation statements)

References 27 publications

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“…CRMP5 antigen is present in small cell lung cancer,5 but not in thymoma,6 indicating that the mechanisms leading to CRMP5 antibodies could be different. As we did not have serum samples from the time of diagnosis of MG, we do not know if there was an initial association with CRMP5 antibodies and thymoma.…”

Section: Discussionmentioning

confidence: 99%

CRMP5 antibodies found in a patient with limbic encephalitis and myasthenia gravis

Monstad

Nøstbakken

Vedeler

2009

Journal of Neurology, Neurosurgery & Psychiatry

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Collapsin response mediator protein 5 (CRMP5) antibodies are often associated with thymoma or small cell lung cancer and paraneoplastic syndromes such as limbic encephalitis (LE). A patient is described with myasthenia gravis who, following thymectomy and immunosuppression, acquired a viral infection and developed LE and increased levels of serum CRMP5 antibodies. The cognitive symptoms improved and CRMP5 antibody levels decreased after plasma exchange, suggesting that CRMP5 antibodies may have contributed to the development of LE.

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Section: Discussionmentioning

confidence: 99%

CRMP5 antibodies found in a patient with limbic encephalitis and myasthenia gravis

Monstad

Nøstbakken

Vedeler

2009

Journal of Neurology, Neurosurgery & Psychiatry

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“…Some cases are associated with testicular, renal and breast tumours. CRMP5 antigen is universally expressed on small-cell lung cancer but not thymoma, which expresses only a 66 kDa peptide common to the CRMP family 7. The clinical syndrome is variable: limbic encephalitis and chorea are most common, but peripheral neuropathy and uveitis may also occur 8 9.…”

Section: Discussionmentioning

confidence: 99%

Anti-collapsin response mediator protein 5 encephalitis masquerading as a low-grade brain tumour

et al. 2016

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A 71-year-old woman presented acutely with seizures; her MRI suggested a low-grade glioma of the right temporal lobe. Over the preceding 18 months, she had developed progressive limb chorea and orofacial dyskinesia. Examination showed a predominantly amnestic cognitive profile. Initial investigations were normal, but later she was found to have antibodies to collapsin response mediator protein 5 (also called CV2). Her symptoms and neuroimaging abnormalities gradually improved without treatment. Four months later, surveillance imaging with (18)F-fluorodeoxyglucose-positron-emission tomography revealed a lesion confirmed by biopsy as a TX, N2, M0 small-cell lung cancer. This case is unusual for the strikingly unilateral neuroimaging abnormalities, which led to an initial misdiagnosis, and the spontaneous symptomatic improvement without treatment. In retrospect, the co-occurrence of paraneoplastic chorea, limbic encephalitis and neuropathy in the presence of an occult lung tumour make this almost a 'full house' of symptoms associated with antibodies to collapsin response mediator protein 5. It underlines the importance in clinical reasoning of avoiding the cognitive errors of premature closure and anchoring.

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“…This is in line with the results of Camdessanché et al . [16], who detected CRMP1, 2, 4 and 5 mRNA in thymus and thymoma by reverse transcription–polymerase chain reaction (RT–PCR), whereas no CRMP1–5 expression was detected by immunohistochemistry or Western blots.…”

Section: Discussionmentioning

confidence: 99%

Antibodies to CRMP3–4 associated with limbic encephalitis and thymoma

Knudsen

Bredholt

Storstein

et al. 2007

Clinical and Experimental Immunology

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SummaryWe present a case with subacute limbic encephalitis (LE) and thymoma. Neither classical onconeural antibodies nor antibodies to voltage gated potassium channels (VGKC) were detected, but the serum was positive for antiglutamic acid decarboxylase (GAD). The patient serum also stained synaptic boutons of pyramidal cells and nuclei of granule cells of rat hippocampus. The objective of the study was to identify new antibodies associated with LE. Screening a cDNA expression library identified collapsin response mediator protein 3 (CRMP3), a protein involved in neurite outgrowth. The serum also reacted with both CRMP3 and CRMP4 by Western blot. Similar binding pattern of hippocampal granule cells was obtained with the patient serum and rabbit anti-serum against CRMP1-4. The CRMP1-4 antibodies stained neuronal nuclei of a biopsy from the patient's temporal lobe, but CRMP1-4 expression in thymoma could only be detected by immunoblotting. Absorption studies with recombinant GAD failed to abolish the staining of the hippocampal granule cells. Our findings illustrate that CRMP3-4 antibodies can be associated with LE and thymoma. This has previously been associated with CRMP5.

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Expression of the onconeural CV2/CRMP5 antigen in thymus and thymoma

Cited by 21 publications

References 27 publications

CRMP5 antibodies found in a patient with limbic encephalitis and myasthenia gravis

CRMP5 antibodies found in a patient with limbic encephalitis and myasthenia gravis

Anti-collapsin response mediator protein 5 encephalitis masquerading as a low-grade brain tumour

Antibodies to CRMP3–4 associated with limbic encephalitis and thymoma

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