Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats

doi:10.1016/s0014-5793(97)01055-7

Cited by 211 publications

(34 citation statements)

References 34 publications

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“…More recently, receptor-mediated mechanisms have been documented, including roles for a transporter for fats, CD36 (also known as platelet glycoprotein 4) 91, 92 , and two GPCRs, GPR40 and GPR120 (also known as free fatty acid receptors 1 and 4, respectively) 93, 94 . CD36 was reported to be localized to the apical tips of some taste bud cells 92 and to elicit elevations in intracellular Ca 2+ levels when stimulated by fatty acids 96 .…”

Section: Chemosensory Transductionmentioning

confidence: 99%

Taste buds: cells, signals and synapses

Roper¹,

2017

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The past decade has witnessed a consolidation and refinement of the extraordinary progress made in taste research. This Review describes recent advances in our understanding of taste receptors, taste buds, and the connections between taste buds and sensory afferent fibres. The article discusses new findings regarding the cellular mechanisms for detecting tastes, new data on the transmitters involved in taste processing and new studies that address longstanding arguments about taste coding.

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Section: Chemosensory Transductionmentioning

confidence: 99%

Taste buds: cells, signals and synapses

Roper¹,

2017

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“…Several proteins located on taste receptor cells are important for dietary fat detection in rodent, including the membrane glycoprotein protein CD 36 [6–8, 101], the G-protein coupled receptors GPR40 and GPR120 [9], and the monovalent cation-selective channel, transient receptor potential channel type M5 (TRPM5) [10]. Genetic deletion of each of these proteins attenuates preferences that rodents display for LCUFAs [6, 7, 9, 10].…”

Section: Proposed Fatty Acid Receptorsmentioning

confidence: 99%

“…CD36 is a multifunctional glycoprotein that is present in a variety of tissues in the body, including the tongue [101]. Immunoreactivity for CD36 was found in rodent and human circumvallate and foliate papillae, with high concentrations of CD36 localized to the apical side of taste buds in lingual epithelium [6, 8, 109]. Recent studies utilized RNAi to selectively reduce the expression of CD36 on the tongue in obesity-prone Osborne-Mendel and obesity-resistant S5B/Pl rats [110].…”

Section: Proposed Fatty Acid Receptorsmentioning

confidence: 99%

Is fat taste ready for primetime?

DiPatrizio

2014

Physiology & Behavior

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Mounting evidence suggests that gustation is important for the orosensory detection of dietary fats, and might contribute to preferences that humans, rodents, and possibly other mammals exhibit for fat-rich foods. In contrast to sweet, sour, salty, bitter, and umami, fat is not widely recognized as a primary taste quality. Recent investigations, however, provide a wealth of information that is helping to elucidate the specific molecular, cellular, and neural mechanisms required for fat detection in mammals. The latest evidence supporting a fat taste will be explored in this review, with a particular focus on recent studies that suggest a surprising role for gut-brain endocannabinoid signaling in controlling intake and preference for fats based on their proposed taste properties.

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“…Two main classes of FA taste receptors have been proposed, CD36 (85) and the G-protein-coupled receptors (GPRs) (22). CD36 is abundantly expressed on the apical surface of taste bud cells in the tongue of rodents, pigs, and humans (43,85) and its deletion reduces spontaneous FA preference in mice (25,85). Consequent to long chain FA binding to CD36 on taste bud cells, a signaling cascade is triggered ultimately resulting in the release of neurotransmitters that relay signals to the central nervous system (37).…”

Section: Other Functions Of Cd36 In the Digestive Tractmentioning

confidence: 99%

Intestinal CD36 and Other Key Proteins of Lipid Utilization: Role in Absorption and Gut Homeostasis

Cifarelli

Abumrad

2018

Comprehensive Physiology

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Several proteins have been implicated in fatty acid (FA) transport by enterocytes including the scavenger receptor CD36 (SR-B2), the scavenger receptor B1 (SR-B1) a member of the CD36 family and the FA transport protein 4 (FATP4). Here, we review the regulation of enterocyte FA uptake and its function in lipid absorption including prechylomicron formation, assembly and transport. Emphasis is given to CD36, which is abundantly expressed along the digestive tract of rodents and humans and has been the most studied. We also address the pleiotropic functions of CD36 that go beyond lipid absorption and metabolism to include recent evidence of its impact on intestinal homeostasis and barrier maintenance. Areas of progress involving contribution of membrane phospholipid remodeling and of cytosolic FA-binding proteins, FABP1 and FABP2 to fat absorption will be covered.

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Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats

Cited by 211 publications

References 34 publications

Taste buds: cells, signals and synapses

Taste buds: cells, signals and synapses

Is fat taste ready for primetime?

Intestinal CD36 and Other Key Proteins of Lipid Utilization: Role in Absorption and Gut Homeostasis

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