Expression of the retinoblastoma gene product in human hepatocellular carcinoma*1

Seki, Shuichi

doi:10.1016/0046-8177(95)90135-3

Cited by 9 publications

(4 citation statements)

References 36 publications

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“…Hui et al (40) suggested that elevated and absent pRb is closely associated with tumor progression and developing metastatic disease rather than tumor initiation in HCC. We could not determine any correlation between the pRb expression and histopathologic features of HCCs, which is consistent with previous reports (16,41).…”

Section: Discussionsupporting

confidence: 89%

Expression of the G1-S Modulators in Hepatitis B Virus-Related Hepatocellular Carcinoma and Dysplastic Nodule: Association of Cyclin D1 and p53 Proteins with the Progression of Hepatocellular Carcinoma

et al. 2001

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Deranged expression of cell cycle modulators has been reported to contribute to the development and progression of hepatocellular carcinoma (HCC). However, their expression patterns remain poorly understood in hepatitis B virus (HBV)-related HCC, which constitutes about 65-70% of HCC in Korea. The aims of this study were to evaluate the expressions of G1-S modulators in HBV-related HCCs and dysplastic nodules (DNs), and to correlate with the histopathologic features of HCCs. Immunohistochemical expressions of cyclin D1, cyclin E, p53, p27, p21, p16, Rb, and PCNA proteins were investigated in 80 HCCs and 22 DNs. Cyclin D1 overexpression showed positive relationships with advanced tumor stage, poor differentiation, larger tumor size, microvascular invasion, intrahepatic metastasis, no tumor capsule formation, infiltrative growth, aberrant p53 expression, and high PCNA labeling index (LI) of HCC (p<0.05). Aberrant p53 expression showed positive relationship with poor differentiation of HCC (p<0.01). Expression of cyclin D1 or p53 was not observed in DNs. The p27 LI and p16 LI were lower in HCCs with intrahepatic metastasis (p<0.05). Cyclin D1 overexpression and aberrant p53 expression could be associated with the progression of HBV-related HCC, and might have a less crucial role in the DN-HCC sequence. In addition, elevated expression of p27 and p16 proteins might have inhibitory action to the intrahepatic metastasis of HBV-related HCC.

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Section: Discussionsupporting

confidence: 89%

Expression of the G1-S Modulators in Hepatitis B Virus-Related Hepatocellular Carcinoma and Dysplastic Nodule: Association of Cyclin D1 and p53 Proteins with the Progression of Hepatocellular Carcinoma

et al. 2001

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“…On the other hand, when a diVerent monoclonal antibody (clone PGM3-245) is used-as in this study-a significant relation between pRb immunostaining and proliferative activity is observed. [6][7][8] The central role of hyperphosphorylated pRb forms in the regulation of the G1/S transition of the cell cycle 1 3 -increasing during G1/ S progression, constant in S/G2 phases, and dephosphorylated in the M phase-supports our finding of a relation between pRb and Ki67 antigen expression. The possibility that Ki-67 immunostaining is related to hyperphosphorylated pRb isoforms rather than to the entire pRb pool has recently been reported by Nieslen et al, 39 who also found a relation between loss of pRb immunostaining in highly proliferating breast tumours and accumulation of hypophosphorylated pRb isoforms by western blot analysis.…”

Section: Discussionsupporting

confidence: 73%

Retinoblastoma (RB1) gene product expression in breast carcinoma. Correlation with Ki-67 growth fraction and biopathological profile.

et al. 1998

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Aims-To investigate the expression of retinoblastoma protein (pRb) in invasive breast tumours and compare its expression with the major biopathological prognostic indicators to identify more aggressive subgroups. Material-Archival paraYn embedded tissues from 153 consecutive primary breast carcinomas. Methods-pRb, Ki-67, and oestrogen receptor/progesterone receptor proteins were identified by immunohistochemistry and score values were recorded by image cytometric analysis; p53 and EGFr expression was also evaluated. Results-pRb scores correlated strongly with proliferation activity as determined by Ki-67 staining. Positive relations were also observed between pRb scores, tumour size, nuclear and histological grade, and oestrogen receptor/progesterone receptor content, while abnormal p53 accumulation was not associated with pRb expression. Among the high proliferating carcinomas it was possible to identify 13 cases with loss of pRb expression. Conclusions-pRb expression paralleled proliferative activity in the majority of breast carcinomas examined, suggesting that in these cases the protein behaves normally in regulating the cell cycle. Conversely in cases with loss of pRb immunostaining, the combined expression of specific highly aggressive factors (EGFr and p53 expression, oestrogen receptor/ progesterone receptor negative status, and high K67) seems to characterise a more aggressive phenotype showing growth advantage and cellular "progression" rather than significant nodal involvement. (J Clin Pathol 1998;51:818-824)

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“…RB1, which inhibits progression from G1 to S phase in the cell cycle, is a tumor-suppressor gene implicated in a wide variety of cancers. RB1 expression, assessed by immunohistochemical analysis, is associated with survival in HCC patients [38,39]. The immunoglobulin superfamily member ALCAM, activated leucocyte cell adhesion molecule (CD166), binds CD6, to function in interactions among neuronal or immune cells.…”

Section: Discussionmentioning

confidence: 99%

Molecular-based prediction of early recurrence in hepatocellular carcinoma

Kurokawa

Matoba

Takemasa

et al. 2004

Journal of Hepatology

112

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Expression of the retinoblastoma gene product in human hepatocellular carcinoma*1

Cited by 9 publications

References 36 publications

Expression of the G1-S Modulators in Hepatitis B Virus-Related Hepatocellular Carcinoma and Dysplastic Nodule: Association of Cyclin D1 and p53 Proteins with the Progression of Hepatocellular Carcinoma

Expression of the G1-S Modulators in Hepatitis B Virus-Related Hepatocellular Carcinoma and Dysplastic Nodule: Association of Cyclin D1 and p53 Proteins with the Progression of Hepatocellular Carcinoma

Retinoblastoma (RB1) gene product expression in breast carcinoma. Correlation with Ki-67 growth fraction and biopathological profile.

Molecular-based prediction of early recurrence in hepatocellular carcinoma

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