2005
DOI: 10.1016/j.ejcb.2005.06.007
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Expression of the skeletal muscle dystrophin–dystroglycan complex and syntrophin-nitric oxide synthase complex is severely affected in the type 2 diabetic Goto–Kakizaki rat

Abstract: The inability of insulin to stimulate glucose metabolism in skeletal muscle fibres is a classic characteristic of type 2 diabetes. Using the non-obese Goto-Kakizaki rat as an established animal model of this type of diabetes, sucrose gradient centrifugation studies were performed and confirmed the abnormal subcellular location of the glucose transporter GLUT4. In addition, this analysis revealed an unexpected drastic reduction in the surface membrane marker b-dystroglycan, a dystrophin-associated glycoprotein.… Show more

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Cited by 27 publications
(37 citation statements)
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“…The total soluble proteome was extracted from the gastrocnemius muscles of 9-week-old normal rats and age-matched GK rats. The diabetic status of the cohort of GK rats employed in this study has previously been described in detail (37).…”
Section: Methodsmentioning
confidence: 99%
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“…The total soluble proteome was extracted from the gastrocnemius muscles of 9-week-old normal rats and age-matched GK rats. The diabetic status of the cohort of GK rats employed in this study has previously been described in detail (37).…”
Section: Methodsmentioning
confidence: 99%
“…it was previously reported that cellular defects in insulin secretion and peripheral insulin resistance occur by 4 weeks of age in the GK rat (30,31). The proteomic profiling of diabetic muscle described here was therefore performed with 9-week-old animals that clearly exhibited elevated levels of glucose (37). diabetic GK skeletal muscles are characterized by an inhibition of insulin receptor auto-phosphorylation (33), impaired activities of numerous key insulin signaling intermediates (32-34), a diminished recruitment of glucose transporter GluT4 molecules possibly linked to membrane cytoskeletal defects in the dystrophin-dystroglycan complex (20,37), drastically lowered mitochondrial enzyme activities (38) and a reduced percentage of oxidative fibres (35).…”
Section: A B C D G E F Discussionmentioning
confidence: 99%
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