Expression of the vitamin D receptor, 25-hydroxylases, 1α-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer

Jensen, Martin Blomberg; Andersen, Claus B.; Nielsen, John; Bagi, Per; Jørgensen, Anne; Juul, Anders; Leffers, Henrik

doi:10.1016/j.jsbmb.2010.03.069

Cited by 74 publications

(53 citation statements)

References 32 publications

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“…Furthermore, Clinckspoor et al (2012) recently highlighted CYP27B1 expression levels as increasing in malignant thyroid tumors. Conversely, immunohistochemical observations by Lopes et al (2010Lopes et al ( , 2012 failed to highlight significant differences in the expression of CYP27B1 between normal breast tissue and tumor tissue while discrepant results were obtained with renal carcinoma (Blomberg Jensen et al, 2010;Urbschat et al, 2013). Because of these conflicting data, no definitive conclusion can be drawn on the consequences of malignant transformation on the expression of CYP27B1.…”

Section: Effects Of Malignant Transformation On 1-a-hydroxylase (Cyp2mentioning

confidence: 98%

Vitamin D in cancer chemoprevention

Giammanco¹,

Majo²,

Guardia

et al. 2015

Pharmaceutical Biology

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Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo. Objective: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy. Methods: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar. Results and conclusion: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.

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Section: Effects Of Malignant Transformation On 1-a-hydroxylase (Cyp2mentioning

confidence: 98%

Vitamin D in cancer chemoprevention

Giammanco¹,

Majo²,

Guardia

et al. 2015

Pharmaceutical Biology

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“…It was shown that the expression of RXR-γ in RCC was correlated with OS of RCC patients (59). Another study discovered that VDR mRNA was almost undetectable in clear cell RCC as compared to normal kidney tissue, and was accompanied by the underexpression of CYP2R1, CYP27B1 and CYP27A1 enzymes (76). No correlation between concentrations of VDR receptors and cancer cell DNA-ploidy was found.…”

Section: Vitamin D Receptors (Vdr)mentioning

confidence: 99%

Hormone signaling pathways as treatment targets in renal cell cancer (Review)

Czarnecka

Niedzwiedzka

Porta

et al. 2016

International Journal of Oncology

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Abstract. Epidemiological, clinical, biochemical and genetic research has revealed that renal cell cancer (RCC) etiology is hormone-related. It was shown that hormone receptors are abnormally expressed in RCC cells. Abnormal endocrine stimulation also plays a significant role in RCC pathophysiology. Cellular proliferation, migration, angiogenesis, and drug resistance in RCC is modulated by para-and autocrine hormonal stimulation. In particular, RCC overexpression of gonadotropin-releasing hormone and its receptor was reported. On the contrary, corticotropin releasing hormone was reported to inhibit RCC cell proliferation and regulate angiogenesis. Overexpression of luteinizing hormone also promotes RCC tumor angiogenesis. Estrogen receptor α overexpression increases the transcriptional factor activity of hypoxia inducible factor HIF-1α, but estrogen receptor β has a cancer suppressive role. Glucocorticoid receptors and androgen receptor are markers of indolent RCC and assigned tumor suppressive activity. Proopiomelanocortin is upregulated in VHL-mutated renal cell carcinoma via Nur77 transcription factor signaling. In RCC, follicle-stimulating hormone receptor promotes angiogenesis and metastatic formation via VEGF release. Mineralocorticoid receptor overexpression promotes cell survival and increases RCC cell proliferation. Vitamin D receptor expression is downregulated or absent in RCC and differentiate subtypes of renal cell tumors. RAR-β promotes tumorigenesis but retinoic acid receptor γ expression correlates negatively with the TNM stage at diagnosis. Finally, progesterone receptor expression is negatively correlated with the cancer stage. Molecular data analysis revealed the possibility of renal cancer cell proliferation induction via hormone activated pathways. Inhibition of hormonal signaling may thus play a putative role in supportive therapies against this cancer type.

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“…A different study by Blomberg Jensen et al showed that VDR mRNA was detected in all normal kidney samples while almost undetectable in clear cell RCC with similar results confirmed by Western blot (Blomberg Jensen et al 2010). Additionally, in this study, the authors investigated the expression of Vitamin D activating enzymes including CYP2R1, CYP27A1, and CYP27B1.…”

Section: Expression Of Vdr In Kidney Tumorsmentioning

confidence: 57%

“…Expression of CYP27B1 was more prominent in the proximal tubule. Expression of these enzymes was diminished in clear cell RCC along with decreased expression of VDR (Blomberg Jensen et al 2010). Papillary RCC is positive for VDR in the great majority of cases.…”

Section: Expression Of Vdr In Kidney Tumorsmentioning

confidence: 99%

“…The effect of calcitriol is negatively controlled by CYP24A1 (Fleet 2008;Nykjaer et al 1999). Immunohistochemistry studies of non-tumoral kidney show expression of VDR predominantly in the distal tubules and collecting ducts with only faint or lack of stain in the proximal tubule cells (Blomberg Jensen et al 2010;Liu et al 2006;). This expression pattern is consistent with studies that demonstrate that vitamin-D induced calcium re-absorption occurs in the distal tubules (Li & Christakos 1991).…”

Section: Expression Of Vdr In the Normal Kidneymentioning

confidence: 99%

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