Expression of the δ-protocadherin gene Pcdh19 in the developing mouse embryo

Gaitan, Yaned; Bouchard, Maxime

doi:10.1016/j.modgep.2006.03.001

Cited by 41 publications

(35 citation statements)

References 26 publications

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“…Pcdh19 expression in the embryonic zebrafish is somewhat similar to that in embryonic mice (Gaitan and Bouchard, 2006). In both species, early Pcdh19 expression is mainly confined to the nervous system.…”

Section: Pcdh19 Expressionmentioning

confidence: 72%

“…In adult rat brain, Pcdh19 was expressed in specific regions of the telencephalon, diencephalon, midbrain and hindbrain (Kim et al 2007). In addition to the neural tissue, Pcdh19 is also expressed by several other tissues in human (RT-PCR analysis, Wolverton and Lalande 2001) and mouse (Gaitan and Bouchard 2006), including the heart and kidney. It remains to be determined if Pcdh19 is expressed by these tissues in larval and adult zebrafish.…”

Section: Pcdh19 Expressionmentioning

confidence: 99%

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Expression of protocadherin-19 in the nervous system of the embryonic zebrafish

Liu¹,

Chen²,

Kubota³

et al. 2010

Int. J. Dev. Biol.

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We have analyzed the expression pattern of protocadherin-19, a member of the δ2-protocadherins, in the nervous system of developing zebrafish using in situ hybridization methods. mRNA encoding protocadherin-19 (Pcdh19) began to be expressed at about 12 hours post fertilization (hpf) showing a segmental expression pattern in the anterior 1/3 of the neural keel, with strong expression in the presumptive forebrain, cerebellum/rhombomere 1 and rhombomere 4. Pcdh19 expression in the posterior neural keel was continuous and confined to the midline region. By 24 hpf, Pcdh19 was expressed widely in the brain and spinal cord, with higher expression levels in the ventral telencephalon, dorsal and central thalamus, optic tectum, central tegmentum, cerebellum and dorsolateral regions of the hindbrain. As development proceeded, Pcdh19 expression domains became restricted to the dorsal and/or lateral regions of the central nervous system, and Pcdh19 expression was not detected in the spinal cord of two-and threeday old embryos. Pcdh19 was also expressed by the eye primordium, developing retina, lens and otic vesicle. Similar to its expression in the brain, Pcdh19 expression in the eye and ear was also spatially and temporally regulated.

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Section: Pcdh19 Expressionmentioning

confidence: 72%

Section: Pcdh19 Expressionmentioning

confidence: 99%

Expression of protocadherin-19 in the nervous system of the embryonic zebrafish

Liu¹,

Chen²,

Kubota³

et al. 2010

Int. J. Dev. Biol.

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“…10,11,20,22 Expression patterns of non-clustered PCDHs in the CNS system have been studied well at protein and/or mRNA levels, although some non-clustered PCDHs such as PCDH1 and PCDH19 are expressed in non-neuronal tissue. 23,24 Expression of PCDH10/OL-PC protein is most extensively studied. PCDH10 protein is expressed in certain local circuits of functional systems such as the olfactory system, nigrostriatal projection, olivocerebellar projection and visual system.…”

Section: Spatial and Temporal Expression Of Non-clustered Pcdhs In Thmentioning

confidence: 99%

Non-clustered protocadherin

Kim¹,

Yasuda²,

Tanaka³

et al. 2011

Cell Adhesion & Migration

218

228

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“…In an effort to find new regulators of kidney development and tumorigenesis, we did a series of microarray experiments comparing (a) wild-type with Pax2 mutant renal cells, (b) early with later stages of mouse mesonephros (embryonic kidney) development, and (c) Pax2-expressing renal cells with surrounding Pax2-negative tissues (36,37). Because Pax genes were found as signature markers for WTs and were previously shown to regulate the tumor suppressor gene Wt1, we examined our microarray results for genes potentially involved in WT.…”

Section: Identification Of Cnabpmentioning

confidence: 99%

Calcineurin A–Binding Protein, a Novel Modulator of the Calcineurin-Nuclear Factor of Activated T-Cell Signaling Pathway, Is Overexpressed in Wilms' Tumors and Promotes Cell Migration

Nguyen

Béland²,

Gaitan³

et al. 2009

Molecular Cancer Research

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Current therapeutic strategies against Wilms' tumor (WT) reach 80% to 85% success rate. In spite of this, a remaining 15% to 20% of tumors relapse and are associated with increased metastasis and poor prognosis. To identify new regulators of WT progression, we screened for developmental target genes of Pax2, a key regulator of kidney development and a WT signature gene. We show that one of these target genes, calcineurin A-binding protein (CnABP), is coexpressed with Pax2 during kidney development and is overexpressed in >70% of WT samples analyzed. The CnABP gene encodes a novel protein product conserved in higher vertebrates. We show that CnABP promotes cell proliferation and migration in cell culture experiments. Biochemical analyses additionally identified an interaction between CnABP and calcineurin Aβ, the catalytic subunit of the calcium-responsive serine/ threonine phosphatase calcineurin. We show that this interaction leads to the inhibition of calcineurin phosphatase activity and prevents nuclear factor of activated T-cell (NFAT) nuclear translocation. Inhibition of NFAT nuclear localization results in decreased NFAT transcriptional response. Together, these data identify a new modulator of calcineurin signaling up-regulated in WTs. (Mol Cancer Res 2009;7(6):821-31)

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Expression of the δ-protocadherin gene Pcdh19 in the developing mouse embryo

Cited by 41 publications

References 26 publications

Expression of protocadherin-19 in the nervous system of the embryonic zebrafish

Expression of protocadherin-19 in the nervous system of the embryonic zebrafish

Non-clustered protocadherin

Calcineurin A–Binding Protein, a Novel Modulator of the Calcineurin-Nuclear Factor of Activated T-Cell Signaling Pathway, Is Overexpressed in Wilms' Tumors and Promotes Cell Migration

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