Expression of thyroid transcription factor-1 in 16 human lung cancer cell lines

Fujita, Jiro; Ohtsuki, Yuji; Bandoh, Shuji; Ueda, Yuichi; Kubo, Akiko; Tojo, Yutaka; Yamaji, Yutaka; Ishida, Takayuki

doi:10.1016/s0169-5002(02)00390-2

Cited by 21 publications

(20 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[25][26][27][28] High levels of TTF-1 expression, as seen in some forms of lung cancer, may result in increased production of SP-A and other SPs and have been shown to cause pulmonary infl ammation and fi brosis in mice. [29][30][31][32] Increased TTF-1 expression has been demonstrated in patients with chronic autoimmune thyroiditis, 33 raising the question of whether increased TTF-1 related to HT may contribute to the increased SP production observed in some patients with IPF.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Disease Is Prevalent and Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis

Oldham

Kumar

Lee

et al. 2015

CHEST

View full text Add to dashboard Cite

BACKGROUND:A signifi cant minority of patients with idiopathic pulmonary fi brosis (IPF) display features of autoimmunity without meeting the criteria for overt connective tissue disease. A link between IPF and other immune-mediated processes, such as hypothyroidism (HT), has not been reported. In this investigation, we aimed to determine whether HT is associated with IPF and if outcomes diff er between patients with IPF with and without HT.

show abstract

Section: Discussionmentioning

confidence: 99%

Thyroid Disease Is Prevalent and Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis

Oldham

Kumar

Lee

et al. 2015

CHEST

View full text Add to dashboard Cite

show abstract

“…Furthermore, Shijubo et al (33,34) found that 27 of 67 patients with lung adenocarcinomas had high levels of SP-A in their pleural effusions, whereas patients with adenocarcinomas originating from different primary sites, other histologic types of lung cancers, and tuberculosis had low levels, suggesting that detection of SP-A in malignant effusions might help distinguish primary lung adenocarcinoma from other adenocarcinomas of miscellaneous origins. However, Fujita et al (35), using both immunohistochemical analysis and reverse transcriptase-PCR, detected SP-A expression in only 1 of 16 lung cancer cell lines, 6 of which were adenocarcinomas. Furthermore, Zamecnik and Kodet (36) observed significantly less SP-A immunoreactivity in poorly differentiated than in well-differentiated lung adenocarcinomas.…”

Section: Discussionmentioning

confidence: 99%

Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer

Jiang¹,

Caraway²,

Bekele

et al. 2005

Clinical Cancer Research

View full text Add to dashboard Cite

Purpose: The present study was conducted to determine clinical relevance of surfactant protein A (SP-A) genetic aberrations in early-stage non^small cell lung cancer (NSCLC). Experimental Design: To determine whether SP-A aberrations are lung cancer^specific and indicate smoking-related damage, tricolor fluorescence in situ hybridization with SP-A and PTEN probes was done on touch imprints from the lung tumors obtained prospectively from 28 patients with primary NSCLC. To further define the clinical relevance of SP-A aberrations, fluorescence in situ hybridization was done on both tumor cells and adjacent bronchial tissue cells from paraffin-embeddedtissueblocksfrom130 patientsNSCLC for whomwehadfollow-upinformation. Results: SP-A was deleted from 89% of cancer tissues and the deletion was related to the smoking status of patients (P < 0.001). PTEN was deleted from 16% in the cancer tissues and the deletion was not related to the smoking status of patients (P > 0.05). In the cells isolated from paraffin-embedded tissue blocks, SP-A was deleted from 87% of the carcinoma tissues and 32% of the adjacent normal-appearing bronchial tissues. SP-A deletions in tumors and adjacent normal-appearing bronchial tissues were associated with increases in the risk of disease relapse (P = 0.0035 and P < 0.001, respectively). SP-A deletions in the bronchial epithelium were the strongest prognostic indicators of disease-specific survival (P = 0.025). Conclusions: Deletions of the SP-A gene are specific genomic aberrations in bronchial epithelial cells adjacent to and within NSCLC, and are associated with tumor progression and a history of smoking. SP-A deletions might be a useful biomarker to identify poor prognoses in patients with NSCLC who might therefore benefit from adjuvant treatment.

show abstract

“…In normally developing epithelial cells of the lung, Nkx2-1 is synthesized in the cytoplasm and transported into the nucleus. In human lung cancer cells, however, Nkx2-1 accumulates in the cytoplasm, as evidenced by low nuclear and high cytoplasmic immunostaining with Nkx2-1 antibody (Fujita et al, 2003). However, the function and significance of cytoplasmic-restricted Nkx2-1 remain unknown (Table 1).…”

Section: Normal Tissue Expressionmentioning

confidence: 99%

Nkx2-1: a novel tumor biomarker of lung cancer

Lin

Ruan

et al. 2012

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell-and tissue-specific expression in normal and cancerous lungs have yet to be fully elucidated. The recent identification of prognostic biomarkers in lung cancer, particularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. The function of Nkx2-1 as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. In this review, we summarize the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.

show abstract

Expression of thyroid transcription factor-1 in 16 human lung cancer cell lines

Cited by 21 publications

References 35 publications

Thyroid Disease Is Prevalent and Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis

Thyroid Disease Is Prevalent and Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis

Surfactant Protein A Gene Deletion and Prognostics for Patients with Stage I Non–Small Cell Lung Cancer

Nkx2-1: a novel tumor biomarker of lung cancer

Contact Info

Product

Resources

About