Expression of Tiam1 in Lung Cancer and its Clinical Significance

Wang, Hongming; Wang, Jing

doi:10.7314/apjcp.2012.13.2.613

Cited by 12 publications

(10 citation statements)

References 18 publications

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“…In normal tissues, with the exception of the brain and testis, TIAM1 expression is absent or at low levels. By contrast, TIAM1 is highly expressed in different types of cancer (particularly metastatic cancer), including colon (20), liver (21)(22)(23), kidney (24), esophagus (25), nasopharynx (26), ovary (13), breast (27) and lung cancer (28).…”

Section: Mirna-22 Suppresses Colon Cancer Cell Migration and Invasionmentioning

confidence: 99%

miRNA-22 suppresses colon cancer cell migration and invasion by inhibiting the expression of T-cell lymphoma invasion and metastasis 1 and matrix metalloproteinases 2 and 9

Song

Liu

et al. 2013

Oncology Reports

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Emerging evidence has demonstrated the altered expression of mRNAs in cancer development and progression. In this study, the precise role of miRNA-22 (miR-22) in colon cancer cells was investigated. Upon transfection with a miR-22 expression vector, the viability of HCT-116 human colon cancer cells was significantly reduced and tumor cell migration and invasion capacity were also suppressed. Computational in silico analysis predicted that T-cell lymphoma invasion and metastasis 1 (TIAM1) is a target gene of miR-22. This was confirmed by qRT-PCR and western blotting, which showed that miR-22 expression inhibited TIAM1 mRNA and protein expression, respectively. In addition, the expression of pro-invasive gene matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) and pro-angiogenic protein vascular endothelial growth factor (VEGF) were also reduced by miR-22 expression. Collectively, these data suggest that miR-22 may act as a tumor suppressor in colon cancer, most likely by targeting TIAM1 expression.

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Section: Mirna-22 Suppresses Colon Cancer Cell Migration and Invasionmentioning

confidence: 99%

miRNA-22 suppresses colon cancer cell migration and invasion by inhibiting the expression of T-cell lymphoma invasion and metastasis 1 and matrix metalloproteinases 2 and 9

Song

Liu

et al. 2013

Oncology Reports

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“…T-cell lymphoma invasion and metastasis 1 (Tiam1), an important protein binds with NDPK-A and inhibits Tiam1 activity specific for Rac1 and therefore interfere with Rac1-mediated actin polymerization and lamellipodia formation, which are essential for cell adhesion and migration (Otsuki et al, 2001;Raftopoulou, and Hall 2004). Tiam1 protein was highly expressed in the lung tumor tissue which is closely related to lung cancer development and metastasis (Wang and Wang, 2012).…”

Section: 3539 Targeting Tumor Metastasis By Regulating Nm23 Gene Expmentioning

confidence: 99%

Targeting Tumor Metastasis by Regulating Nm23 Gene Expression

Prabhu

Siddikuzzaman²,

Grace³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The Nm23 gene is a metastatic suppressor identified in a melanoma cell line and expressed in different tumors where their levels of expression are associated with reduced or increased metastatic potential. Nm23 is one of the over 20 metastasis suppressor genes (MSGs) confirmed in vivo. It is highly conserved from yeast to human, implying a critical developmental function. Tumors with alteration of the p53 gene and reduced expression of the Nm23 gene are more prone to metastasis. Nm23-H1 has 3'-5' exonuclease activity. This review focuses on the role of Nm23 in cancer progression and also a potential novel target for cancer therapy.

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“…Many studies have shown that TIAM1 and TIAM2, which belong to TIAM-family guanine nucleotide exchange proteins, can activate Rac1 GTPase (Shepherd et al, 2011). TIAM1 expression is closely related to lung cancer development and metastasis (Wang et al, 2012), and can be used as a marker for the prognosis of hepatocellular carcinoma RESEARCH ARTICLE…”

Section: Introductionmentioning

confidence: 99%

TIAM2 Enhances Non-small Cell Lung Cancer Cell Invasion and Motility

Zhao

Han²,

Liu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: TIAM2, a Rac guanine nucleotide exchange factor, is closely associated with cell adherence and migration. Here, we aimed to investigate the role of TIAM2 in non-small cell lung cancer (NSCLC) cells. Materials and Methods: A small interference RNA (siRNA) was introduced to silence the expression of TIAM2. Invasion and motility assays were then performed to assess the invasion and motility potential of NSCLC cells. GST-pull down assays were used to detect activation of Rac1. Results: TIAM2 was highly expressed in NSCLC cells. Knockdown of TIAM2 inhibited the invasion and motility, and suppressed activation of Rac1. Further experiments demonstrated that knockdown of TIAM2 could up-regulate the expression of E-cadherin, and downregulate the expression of MMP-3, Twist and Snail. Conclusions: Our data suggest that TIAM2 can promote invasion and motility of NSCLC cells. Activation of Rac1 and regulation of some EMT/invasion-related genes may be involved in the underlying processes.

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Expression of Tiam1 in Lung Cancer and its Clinical Significance

Cited by 12 publications

References 18 publications

miRNA-22 suppresses colon cancer cell migration and invasion by inhibiting the expression of T-cell lymphoma invasion and metastasis 1 and matrix metalloproteinases 2 and 9

miRNA-22 suppresses colon cancer cell migration and invasion by inhibiting the expression of T-cell lymphoma invasion and metastasis 1 and matrix metalloproteinases 2 and 9

Targeting Tumor Metastasis by Regulating Nm23 Gene Expression

TIAM2 Enhances Non-small Cell Lung Cancer Cell Invasion and Motility

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