Expression of Tn, sialosyl Tn, and T antigens in human pancreas

Itzkowitz, Steven H.; Kjeldsen, Thomas; Friera, Annabelle M.; Hakomori, S; Yang, Ung Suk; Kim, Young S.

doi:10.1016/0016-5085(91)90671-7

Cited by 285 publications

(333 citation statements)

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“…[23][24][25][26] For example, sialylated T and Tn antigens and sialylated Lewis blood group antigens were originally described as tumor-associated antigens on mucins. 27,28 Sialyl-Lewis x/a expression has also been strongly correlated with poor prognosis in a variety of human carcinomas. 23,24,26,29 -36 Thus, it has been suggested that E-selectin-bearing endothelial cells may be interacting with carcinoma cells via these sialylated, fucosylated epitopes.…”

mentioning

confidence: 99%

Distinct Selectin Ligands on Colon Carcinoma Mucins Can Mediate Pathological Interactions among Platelets, Leukocytes, and Endothelium

Kim

Borsig

Han

et al. 1999

The American Journal of Pathology

175

130

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mentioning

confidence: 99%

Distinct Selectin Ligands on Colon Carcinoma Mucins Can Mediate Pathological Interactions among Platelets, Leukocytes, and Endothelium

Kim

Borsig

Han

et al. 1999

The American Journal of Pathology

175

130

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“…STn expression appeared to correlate with the histological grade (86% of well-diÂerentiated and 46% of poorly diÂerentiated carcinoma) possibly because most welldiÂerentiated prostatic carcinomas contain mucin and moderately or poorly diÂerentiated tumours tend to be negative for mucin [17,18]. In other organs, STn is frequently expressed in well-diÂerentiated carcinoma of the colon [5], pancreas [6], ovary [7] and endometrium [8]. In routine prostatic H&E sections, it is sometimes diÃcult to distinguish well-diÂerentiated carcinoma from the benign region; STn appears to show better selectivity The immunostaining of basal cells using keratin antibodies such as 34bE12 is widely accepted for the diÂerential diagnosis of prostatic carcinoma and benign tissue [19,20], i.e.…”

Section: Resultsmentioning

confidence: 99%

“…Immunohistochemical studies have shown with carcinoma was 74.3 (47-89) years and of patients with BPH was 73.4 (60-87) years. The specimens were the presence of STn in human gastrointestinal [5], pancreatic [6], ovarian [7] and endometrial [8] carciobtained from Tru-cut needle biopsies or transurethral resection. None of the patients with prostatic carcinoma noma cells, whereas its expression in normal or hyperplastic tissues is highly restricted [9].…”

Section: Methodsmentioning

confidence: 99%

Immunohistochemical detection of sialosyl‐Tn antigen in carcinoma of the prostate

Kuwabara

Uda

Takenaka

1997

British Journal of Urology

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Objective To investigate the expression of sialosyl‐Tn antigen (STn) in human benign and malignant prostate. Materials and methods The expression of STn was investigated immunohistochemically in formalin‐fixed and paraffin‐embedded tissue specimens from 56 patients with primary prostatic adenocarcinoma (median age 74.3 years, range 47–89) and 20 patients with benign prostatic hyperplasia (median age 73.4 years, range 60–87). Results STn was expressed in only three (4%) of the 20 hyperplastic glands and the benign areas adjacent to the 54 carcinomas; by contrast, STn was expressed in 34 (61%) of the 56 carcinomas. The frequency of STn positivity was much higher in well‐differentiated carcinomas than in those poorly differentiated. Conclusion STn is expressed with malignant transformation of the prostatic epithelial cells and immunohistochemical methods using commercially available STn monoclonal antibody may be useful as an adjunct for distinguishing carcinoma from benign tissue.

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“…Itzkowitz et al (1989Itzkowitz et al ( , 1990 reported that the rate of expression of STN is low in normal colon mucosa, and that expression of STN is an independent prognostic factor for colon cancer patients. STN is little expressed in the normal stomach mucosa, yet it is expressed in 47.8-54.1% of cancer cells (Maeda et al, 1992;Yamada et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

“…STN is an abnormal glycoprotein, detected using monoclonal antibody TKH-2 (Kjeldsen et al, 1988) and specific to cancer tissue. STN is expressed in colon cancer cells but not in normal colon cells (Itzkowitz et al, 1989). In gastric cancer tissue, STN is expressed specifically in malignant cells (Maeda et al, 1992;Yamada et al, 1992).…”

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confidence: 99%

Combined evaluation of preoperative serum sialyl-Tn antigen and carcinoembryonic antigen levels is prognostic for gastric cancer patients

Takahashi

Maehara²,

Kusumoto³

et al. 1994

Br J Cancer

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We have found that elevation of preoperative serum sialyl-Tn antigen (STN) levels is associated with a poor prognosis for gastric cancer patients, and these high levels remain in the advanced stage of the disease. We have now examined findings with the combined assay of STN and carcinoembryonic antigen (CEA) levels with regard to prediction of the prognosis of gastric cancer patients. Serum CEA levels and STN levels were determined preoperatively in 349 Japanese patients with gastric cancer. The patients were divided into four groups: (A) the CEA (-) STN (-) group (CEA < or = 5 ng ml-1, STN < or = 45 U ml-1, n = 286); (B) the CEA (-) STN (+) group (CEA < or = 5 ng ml-1, STN > 45 U ml-1, n = 31); (C) the CEA (+) STN (-) group (CEA > 5 ng ml-1, STN < or = 45 U ml-1, n = 17); and (D) the CEA (+) STN (+) group (CEA > 5 ng ml-1, STN > 45 U ml-1, n = 15). Clinicopathological features and the prognosis of these groups were examined. The distribution of two markers showed no significant correlation. The patients in the CEA (+) STN (+) group (group D) had more advanced disease than the patients in CEA (-) STN (-) group (group A); tumour size was larger, serosal invasion was prominent, lymphatic and vascular involvement was frequent and the tumour was more infiltrative. Lymph node metastasis and hepatic metastasis were more common. Total gastrectomy was usually performed, and the non-curative rate was higher. The 5-year survival of patients in the CEA (+) STN (+) (group D) was 14.5 +/- 9.5%, that is lower than that of patients in any other group [CEA (+) STN (-) (group C) 44.1 +/- 12.7% (P < 0.05); CEA (-) STN (+) (group B) 60.1 +/- 9.5% (P > 0.05); CEA (-) STN (-) (group A) 77.6 +/- 9.5% (P < 0.05)]. This combined assay of these markers will aid in estimating the prognosis and selecting appropriate drugs and care for gastric cancer patients.

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Expression of Tn, sialosyl Tn, and T antigens in human pancreas

Cited by 285 publications

References 18 publications

Distinct Selectin Ligands on Colon Carcinoma Mucins Can Mediate Pathological Interactions among Platelets, Leukocytes, and Endothelium

Distinct Selectin Ligands on Colon Carcinoma Mucins Can Mediate Pathological Interactions among Platelets, Leukocytes, and Endothelium

Immunohistochemical detection of sialosyl‐Tn antigen in carcinoma of the prostate

Combined evaluation of preoperative serum sialyl-Tn antigen and carcinoembryonic antigen levels is prognostic for gastric cancer patients

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