Expression of toll-like receptors and proinflammatory cytokines in human placenta

Moroi, Hiroaki; Kotani, Tomomi; Mano, Yukio; Tsuda, Hiroyuki; Sato, Seiji; Kikkawa, Fumitaka

doi:10.1016/j.placenta.2014.08.084

Cited by 1 publication

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“…We identified 14 studies describing UAPA impacting 22 pregnancies. 4 8 9 10 11 12 13 14 15 16 17 18 19 The median age at diagnosis in our study was 21 years versus a median age of 14 years reported in studies not restricted to pregnant patients. 3 This may reflect selection, where those with more severe symptoms facilitating earlier diagnosis are less likely to pursue pregnancy.…”

Section: Discussionmentioning

confidence: 51%

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Unilateral Absent Pulmonary Artery in Pregnancy: A Case Report and Systematic Literature Review

Kucirka,

Desai,

LeVarge

et al. 2023

Am J Perinatol

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Objective Unilateral absence of a pulmonary artery (UAPA) is a rare congenital malformation associated with hemoptysis, pulmonary hypertension, and infection. Little is known about the impact on pregnancy outcomes. We sought to synthesize the existing literature on pregnancy outcomes in patients with maternal UAPA. Study Design We report a case of maternal UAPA and performed a systematic review of the existing literature. Articles in English reporting pregnancy outcomes among women with unilateral absence or hypoplasia of the pulmonary artery were included. Articles were reviewed at the abstract level and, if eligible, at the full-text level by two independent reviewers with disagreements adjudicated by a third reviewer. Data were abstracted by two independent reviewers. Outcomes of interest were mode of delivery, gestational age at delivery, intensive care admission, maternal death, and length of stay. Summary statistics for each outcome are presented. Results We identified 14 studies, including the presented case, reporting outcomes in 22 pregnancies impacted by maternal UAPA. Median age at diagnosis was 21 years. Concurrent cardiac comorbidities were reported in 6/13 (46.2%) with pulmonary hypertension in 5/20 (25%) of cases where this information was reported. We observed high rates of preterm birth (4/12, 33.3%), cesarean delivery (10/15, 66.7%), and operative vaginal delivery (2/5, 40.0%). There was one maternal death occurring in the immediate postpartum period for a mortality rate of 4.5%. Conclusion Our study provides a comprehensive review of existing literature on maternal UAPA. Our findings suggest increased rates of adverse outcomes and underscore the importance of early diagnosis, identification of pulmonary hypertension, and multidisciplinary care. Key Points

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Section: Discussionmentioning

confidence: 51%

“…We also included the case that is published in this paper, for a total of 14 studies. 4 8 9 10 11 12 13 14 15 16 17 18 19…”

Section: Resultsmentioning

confidence: 99%

Unilateral Absent Pulmonary Artery in Pregnancy: A Case Report and Systematic Literature Review

Kucirka,

Desai,

LeVarge

et al. 2023

Am J Perinatol

View full text Add to dashboard Cite

show abstract

Expression of toll-like receptors and proinflammatory cytokines in human placenta

Cited by 1 publication

References 0 publications

Unilateral Absent Pulmonary Artery in Pregnancy: A Case Report and Systematic Literature Review

Unilateral Absent Pulmonary Artery in Pregnancy: A Case Report and Systematic Literature Review

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