Expression of Toll-like receptors (TLR), in lymphoid organ of black tiger shrimp (Penaeus monodon) in response to Vibrio harveyi infection

Dechamma, Mundanda Muthappa; Rajeish, Moger; Maiti, Biswajit; Mani, Madhu K.; Karunasagar, Indrani

doi:10.1016/j.aqrep.2015.02.002

Cited by 23 publications

(10 citation statements)

References 23 publications

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“…TLR showed a significant downregulation during the first 24 h p.i., which corresponded with previous observations of downregulated Toll protein expression in Fenneropenaeus chinensis after stimulation with white spot syndrome virus (Yang et al 2008) and with the peak TLR expression in the lymphoid organ at 24 h after injection challenge with V. harveyi (Dechamma et al 2015). An upregulation at 48 h p.i.…”

Section: Discussionsupporting

confidence: 91%

“…) and β‐glucan (Dechamma et al . ) in the diet resulted in the upregulated expression of TLR , suggesting they would be meaningful methods to preventing AHPND based on the immune responses we observed after challenge. The previously described immersion model (Tran et al .…”

Section: Discussionmentioning

confidence: 82%

“…) and with the peak TLR expression in the lymphoid organ at 24 h after injection challenge with V. harveyi (Dechamma et al . ). An upregulation at 48 h p.i.…”

Section: Discussionmentioning

confidence: 97%

“…) and play vital roles against Vibrio harveyi (Dechamma et al . ). Therefore, the gene expression levels of LSZ and TLR can reflect the immune response of shrimp after bacterial challenge.…”

Section: Introductionmentioning

confidence: 97%

“…Toll-like receptors (TLRs) are transmembraneous glycoproteins that meditate a series of immune responses from the extracellular to intracellular regions and play vital roles in sensing microbial pathogens and non-specific immunity. TLRs are basic conserved components of the innate immune system (Beutler 2004) which have shown relatively high expression in haemocytes, gills and nerves in shrimp P. vannamei (Yang et al 2007) and play vital roles against Vibrio harveyi (Dechamma et al 2015). Therefore, the gene expression levels of LSZ and TLR can reflect the immune response of shrimp after bacterial challenge.…”

Section: Introductionmentioning

confidence: 99%

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Identification and pathogenicity of Vibrio parahaemolyticus isolates and immune responses of Penaeus (Litopenaeus) vannamei (Boone)

Hong

Zhuo

et al. 2016

Journal of Fish Diseases

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Five different Vibrio parahaemolyticus strains (SH8, SH108, SH58, AH5 and GD10) isolated from the hepatopancreas of moribund shrimp in farms of mainland China were identified and capable of inducing massive mortality of Penaeus (Litopenaeus) vannamei. The immersion challenge results with five isolates indicated variance of virulence, while only GD10 caused massive sloughing of tubule epithelial cells which was recognized as the most significant symptom of AHPND. Differences in immune responses were detected of P. vannamei during 48 h post-infection (p.i.) by injection or immersion challenge with V. parahaemolyticus (SH8, SH108 and GD10) isolates. When injected SH8 and SH108 isolates, the expression of lysozyme (LSZ) showing statistically significant upregulation at 16 and 48 h p.i. and that of Toll-like receptors (TLR) showed statistically significant upregulation at 48 h p.i. When immersion challenge with the GD10 isolate, TLR were upregulated after 8 h p.i. challenge with 10(4) cfu mL(-1) ; however, LSZ was downregulated when challenged with 10(3) cfu mL(-1) . The results suggested that LSZ and TLR serve as crucial molecular markers of innate immunity in shrimp against V. parahaemolyticus infection. LSZ is a vital marker for acute bacterial infection, while TLR serves as a crucial marker for chronic infection.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 82%

“…) and with the peak TLR expression in the lymphoid organ at 24 h after injection challenge with V. harveyi (Dechamma et al . ). An upregulation at 48 h p.i.…”

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Identification and pathogenicity of Vibrio parahaemolyticus isolates and immune responses of Penaeus (Litopenaeus) vannamei (Boone)

Hong

Zhuo

et al. 2016

Journal of Fish Diseases

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Shrimp Immune System and Immune Responses

Rajendran¹,

Sreedharan²,

Deepika³

et al. 2022

Fish Immune System and Vaccines

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Genome dynamics and evolution of codon usage patterns in shrimp viruses

2017

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We analysed the genomes and codon usage patterns of seven small (DNA and RNA) shrimp viruses. Effective number of codon (ENC) values indicated moderate (35 < ENC < 50) codon usage bias in shrimp viruses. Correlation analysis between GC compositions at non-synonymous codon and synonymous codon positions (GC1, 2 and GC3) as well as GC3 versus ENC curves indicated varying influences of mutational pressure on codon usage. The presence of deoptimized codons and host-antagonistic codon usage trends in shrimp viruses suggested the adaptation of a slow replication strategy by these viruses to avoid host defences. Low CpG frequencies indicated that shrimp viruses have evolved with underrepresentation of CpGs to avoid the host's immune response.

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Expression of Toll-like receptors (TLR), in lymphoid organ of black tiger shrimp (Penaeus monodon) in response to Vibrio harveyi infection

Cited by 23 publications

References 23 publications

Identification and pathogenicity of Vibrio parahaemolyticus isolates and immune responses of Penaeus (Litopenaeus) vannamei (Boone)

Identification and pathogenicity of Vibrio parahaemolyticus isolates and immune responses of Penaeus (Litopenaeus) vannamei (Boone)

Shrimp Immune System and Immune Responses

Genome dynamics and evolution of codon usage patterns in shrimp viruses

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