Expression of transforming growth factor-β and insulin-like growth factor in molar and placental tissues

Pang, Zhan-Jun; Xing, Fu-qi

doi:10.1007/s00404-002-0379-3

Cited by 13 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TGF-β3 mRNA was expressed in complete hydatidiform mole (CHM), normal first-trimester villi, the normal term placenta (after vaginal/abdominal deliver) and the preeclamptic placenta at term, while TGF-β1 and TGF-β2 mRNA were not detected; and TGF-β3 expression was higher in CMH than normal first-trimester villi (the expression levels of TGF-β3 in the preeclamptic placenta and the normal placenta after cesarean birth were higher than in the placenta after vaginal delivery). 120 Another study of partial hydatidiform moles (PHM), complete hydatidiform moles, and choriocarcinoma, using nonhydropic spontaneous abortions as controls, concurs with TGF-β3 expression in all groups with the highest level in CHM and choriocarcinoma, being stronger in complete moles than that of choriocarcinomas although difference was not significant, and for TGF-β1 expression was highest in controls, and reduced in PHM, CHM and choriocarcinoma, the last with a minimum value. 121 Summarizing, TGF-β1/2 expression is downregulated while for TGF-β3 is up-regulated in GTD.…”

Section: The Tgf-β Axis and The Pathogenesis Of Gtdmentioning

confidence: 82%

Role of the Insulin-like growth factor axis and the Transforming growth factor-β in the regulation of the placenta and the pathogenesis of Gestational Trophoblastic Diseases

Umaña‐Pérez

Novoa-Herrán

Castro

et al. 2020

MRAJ

View full text Add to dashboard Cite

During human pregnancy, the trophoblast develops as the fetal compartment, while in bidirectional communication with the maternal decidua. The trophoblast is responsible for the adequate implantation of the embryo, supply of nutrients and environmental protection of the fetus along the progress of pregnancy. To perform these functions trophoblast cells, undergo a complex and finely tuned differentiation into specialized groups of cells, in a process regulated by several hormones, growth factors and cytokines. Abnormalities in trophoblast function result in several pregnancy complications. In this review, we focus our attention on two growth factors with pivotal roles during human pregnancy. The Insulin-like growth factor (IGF) family and the Transforming growth factor (TGF-β) axis are important regulators of the proliferation, differentiation, apoptosis, migration and invasion of human trophoblasts. We summarize what is described in the literature on how these factors and their receptors are expressed on the different subsets of trophoblasts, the signaling pathways that transduce their corresponding actions and functional biological effects. We describe the associations that have been found between these growth factors and the group of pathologies known as Gestational Trophoblastic Diseases (GTD).

show abstract

Section: The Tgf-β Axis and The Pathogenesis Of Gtdmentioning

confidence: 82%

Role of the Insulin-like growth factor axis and the Transforming growth factor-β in the regulation of the placenta and the pathogenesis of Gestational Trophoblastic Diseases

Umaña‐Pérez

Novoa-Herrán

Castro

et al. 2020

MRAJ

View full text Add to dashboard Cite

show abstract

“…Some studies showed that low TGF-β levels increase the probability of preterm birth in women [123][124][125]. Besides, TGF-β3 was increased in people with gestational trophoblastic disease, suggesting that TGF-β3 may be significantly involved in the process of gestational trophoblastic disease [126,127].…”

Section: Other Pregnancy Complicationsmentioning

confidence: 99%

The Role of TGF-β during Pregnancy and Pregnancy Complications

Wen,

Liao,

Lin

et al. 2023

IJMS

View full text Add to dashboard Cite

Transforming growth factor beta (TGF-β), a multifunctional cytokine, is one of the most important inflammatory cytokines closely related to pregnancy. It plays significant roles in hormone secretion, placental development, and embryonic growth during pregnancy. TGF-β is implicated in embryo implantation and inhibits the invasion of extraepithelial trophoblast cells. It also moderates the mother-fetus interaction by adjusting the secretion pattern of immunomodulatory factors in the placenta, consequently influencing the mother’s immune cells. The TGF-β family regulates the development of the nervous, respiratory, and cardiovascular systems by regulating gene expression. Furthermore, TGF-β has been associated with various pregnancy complications. An increase in TGF-β levels can induce the occurrences of pre-eclampsia and gestational diabetes mellitus, while a decrease can lead to recurrent miscarriage due to the interference of the immune tolerance environment. This review focuses on the role of TGF-β in embryo implantation and development, providing new insights for the clinical prevention and treatment of pregnancy complications.

show abstract

“…TGF-b is expressed on decidua of normal trophoblast cells, molar pregnancies, and choriocarcinoma patients (78,79) . Normal EVT cell functions, such as proliferation, migration, and invasion, are controlled by decidua-derived TGF-b, whereas choriocarcinoma cell lines are resistant to the antiproliferative and antiinvasive effect of TGF-b (80) .…”

Section: Suppressive Cytokinesmentioning

confidence: 99%

Immunobiology of gestational trophoblastic diseases

Wang¹,

Fu²,

Freedman³

et al. 2006

Int J Gynecol Cancer

View full text Add to dashboard Cite

Gestational trophoblastic diseases (GTDs) comprise a group of interrelated diseases characterized by development after gestation, widespread metastases, and high curability with chemotherapy. The good prognosis of GTDs is considered partly a result of the host immune response to paternal antigens expressed on trophoblastic cells. In this study, we review current understanding of the immunobiology of GTDs. First of all, we describe the microenvironment between trophoblastic cells and subpopulation of immune cells. Second, immunogenetics, immune microenvironment around abnormal trophoblast, and mechanism of GTDs escaping from maternal immune system surveillance were also discussed. Third, we propose the possible immunotherapy for persistent GTDs, particularly the vaccine designed on human chorionic gonadotrophin, which is generally accepted as a tumor marker for GTDs diagnosis. Due to the low incidence of GTDs and high response to chemotherapy, there have been few literatures about immunobiologic characteristics of GTDs compared with the other gynecologic malignancies, such as ovarian cancer, but the immunologic behavior of GTDs should be explored for further understanding of the etiology of these diseases and to help designing immunotherapeutic strategies for persistent GTDs.

show abstract

Expression of transforming growth factor-β and insulin-like growth factor in molar and placental tissues

Cited by 13 publications

References 19 publications

Role of the Insulin-like growth factor axis and the Transforming growth factor-β in the regulation of the placenta and the pathogenesis of Gestational Trophoblastic Diseases

Role of the Insulin-like growth factor axis and the Transforming growth factor-β in the regulation of the placenta and the pathogenesis of Gestational Trophoblastic Diseases

The Role of TGF-β during Pregnancy and Pregnancy Complications

Immunobiology of gestational trophoblastic diseases

Contact Info

Product

Resources

About