Expression of two zebrafish orthodenticle-related genes in the embryonic brain

Li, Yuebing; Allende, Miguel L.; Finkelstein, Robert; Weinberg, Eric S.

doi:10.1016/0925-4773(94)90062-0

Cited by 210 publications

(127 citation statements)

References 48 publications

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“…expression pattern in the hindbrain (Fig. 1L), and the pax2.1 (Krauss et al, 1991) and otx2 (Li et al, 1994) patterns in mid-and forebrain (data not shown). This phenotypic trait has previously been described for the mutant snh st1 , which carries a deletion including the bmp7 gene (Dick et al, 2000).…”

mentioning

confidence: 78%

Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations

Lele

Bakkers

Hammerschmidt

2001

Genesis

100

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mentioning

confidence: 78%

Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations

Lele

Bakkers

Hammerschmidt

2001

Genesis

100

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“…The following in situ probes were used: axin2 (kind gift of R. Dorsky), dkk1 (gift from C. Houart), follistatin (Bauer et al, 1998), otx1 (Li et al, 1994), atoh7 (atoh7, (Kay et al, 2001), sox2 (Okuda et al, 2006), myca and cyclinD1 , pax6a (Krauss et al, 1991), stat3 (Krauss et al, 1991), her6 (Pasini et al, 2004), meis1 (Waskiewicz et al, 2001), vsx2 (Barabino et al, 1997 …”

Section: In Situ Hybridization and Immunohistochemistrymentioning

confidence: 99%

Loss of adenomatous polyposis coli (apc) results in an expanded ciliary marginal zone in the zebrafish eye

Stephens

Senecal

Nguyen

et al. 2010

Developmental Dynamics

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The distal region of neural retina (ciliary marginal zone [CMZ]) contains stem cells that produce non-neural and neuronal progenitors. We provide a detailed gene expression analysis of the eyes of apc mutant zebrafish where the Wnt/b-catenin pathway is constitutively active. Wnt/b-catenin signaling leads to an expansion of the CMZ accompanied by a central shift of the retinal identity gene sox2 and the proneural gene atoh7. This suggests an important role for peripheral Wnt/b-catenin signaling in regulating the expression and localization of neurogenic genes in the central retina. Retinal identity genes rx1 and vsx2, as well as meis1 and pax6a act upstream of Wnt/b-catenin pathway activation. Peripheral cells that likely contain stem cells can be identified by the expression of follistatin, otx1, and axin2 and the lack of expression of myca and cyclinD1. Our results introduce the zebrafish apc mutation as a new model to study signaling pathways regulating the CMZ.

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“…In the zebrafish, representatives of otx and nkx families are expressed in the ear, but a functional role in semicircular canal development has not yet been demonstrated. otx1 and otx3, related to the Drosophila gene orthodenticle, are expressed in a discrete ventral region of the otic epithelium from mid-somite stages (Li et al, 1994;Mercier et al, 1995). nkx5.1, as discussed in the Neurogenesis and Formation of the Statoacoustic Ganglion section, is expressed in a ventral region of the zebrafish ear, which appears to be associated with the neurogenic region (Adamska et al, 2000).…”

Section: Development Of Semicircular Canalsmentioning

confidence: 99%

Development of the zebrafish inner ear

Whitfield

Riley

Chiang

et al. 2002

Developmental Dynamics

214

186

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Recent years have seen a renaissance of investigation into the mechanisms of inner ear development. Genetic analysis of zebrafish has contributed significantly to this endeavour, with several dramatic advances reported over the past year or two. Here, we review the major findings from recent work in zebrafish. Several cellular and molecular mechanisms have been elucidated, including the signaling pathways controlling induction of the otic placode, morphogenesis and patterning of the otic vesicle, and elaboration of functional attributes of inner ear.

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Expression of two zebrafish orthodenticle-related genes in the embryonic brain

Cited by 210 publications

References 48 publications

Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations

Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations

Loss of adenomatous polyposis coli (apc) results in an expanded ciliary marginal zone in the zebrafish eye

Development of the zebrafish inner ear

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