Expression of tyrosine kinase receptor C in the segments of the spinal cord and the cerebral cortex after cord transection in adult rats

Qian, Dong-Xiang; Zhang, Hongtian; Cai, Yuchen; Luo, Peng; Xu, Ran

doi:10.1007/s12264-011-1150-1

Cited by 5 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tyrosine kinase receptor C (TrkC) protein decreased within 7 days after spinal cord transection and began to increase after 7 days, which was significantly accelerated in another 7 days. This was consistent with the changes of TrkC mRNA expression [ 10 ]. The mRNA expression of the p75 neurotrophic factor receptor fluctuated after SCI and was positively correlated with neuronal apoptosis, which could be a regulatory factor during the neuronal repair of SCI [ 11 ].…”

Section: Neurotrophic Factors For Scisupporting

confidence: 88%

Sustained delivery of neurotrophic factors to treat spinal cord injury

Muheremu

Liang

et al. 2021

Translational Neuroscience

View full text Add to dashboard Cite

Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical and psychological harm and a series of socioeconomic problems. Although neurons in the spinal cord need neurotrophic factors for their survival and development to reestablish their connections with their original targets, endogenous neurotrophic factors are scarce and the sustainable delivery of exogeneous neurotrophic factors is challenging. The widely studied neurotrophic factors such as brain-derived neurotrophic factor, neurotrophin-3, nerve growth factor, ciliary neurotrophic factor, basic fibroblast growth factor, and glial cell-derived neurotrophic factor have a relatively short cycle that is not sufficient enough for functionally significant neural regeneration after SCI. In the past decades, scholars have tried a variety of cellular and viral vehicles as well as tissue engineering scaffolds to safely and sustainably deliver those necessary neurotrophic factors to the injury site, and achieved satisfactory neural repair and functional recovery on many occasions. Here, we review the neurotrophic factors that have been used in trials to treat SCI, and vehicles that were commonly used for their sustained delivery.

show abstract

Section: Neurotrophic Factors For Scisupporting

confidence: 88%

Sustained delivery of neurotrophic factors to treat spinal cord injury

Muheremu

Liang

et al. 2021

Translational Neuroscience

View full text Add to dashboard Cite

show abstract

“…Trk mRNA expression is downregulated acutely in the SC at and around the injury site after contusion (Liebl et al, 2001; Hajebrahimi et al, 2008), however by 6 weeks expression levels are not different from control (Liebl et al, 2001). However, after SC transection TrkC has been shown to increase after 2 weeks (Qian et al, 2011). Similarly, in a recent study assessing mRNA and protein changes after transection at 10 and 31 days post injury, whole SC TrkB mRNA was elevated at 10 days post injury, and whole SC NT3 and TrkB protein was elevated at 31 days post injury, with expression differences also observed depending on the location within the parenchyma of the SC (Keeler et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…However, these have largely focused on time points of less than 6 weeks (Hayashi et al, 2000; Liebl et al, 2001; Nakamura and Bregman, 2001; Widenfalk et al, 2001; Qiao and Vizzard, 2002, 2005; Gulino et al, 2004; Zvarova et al, 2004; Qin et al, 2006; Li et al, 2007; Hajebrahimi et al, 2008; Qian et al, 2011; Keeler et al, 2012). Although valuable for elucidating the role of neurotrophin signaling in the first 6 weeks after SCI, these data are of uncertain value for relating to longer-term post-SCI function.…”

Section: Introductionmentioning

confidence: 99%

The Transcriptional Response of Neurotrophins and Their Tyrosine Kinase Receptors in Lumbar Sensorimotor Circuits to Spinal Cord Contusion is Affected by Injury Severity and Survival Time

Hougland¹,

Harrison²,

Magnuson³

et al. 2013

Front. Physio.

View full text Add to dashboard Cite

Traumatic spinal cord injury (SCI) results in changes to the anatomical, neurochemical, and physiological properties of cells in the central and peripheral nervous system. Neurotrophins, acting by binding to their cognate Trk receptors on target cell membranes, contribute to modulation of anatomical, neurochemical, and physiological properties of neurons in sensorimotor circuits in both the intact and injured spinal cord. Neurotrophin signaling is associated with many post-SCI changes including maladaptive plasticity leading to pain and autonomic dysreflexia, but also therapeutic approaches such as training-induced locomotor improvement. Here we characterize expression of mRNA for neurotrophins and Trk receptors in lumbar dorsal root ganglia (DRG) and spinal cord after two different severities of mid-thoracic injury and at 6 and 12 weeks post-SCI. There was complex regulation that differed with tissue, injury severity, and survival time, including reversals of regulation between 6 and 12 weeks, and the data suggest that natural regulation of neurotrophins in the spinal cord may continue for months after birth. Our assessments determined that a coordination of gene expression emerged at the 12-week post-SCI time point and bioinformatic analyses address possible mechanisms. These data can inform studies meant to determine the role of the neurotrophin signaling system in post-SCI function and plasticity, and studies using this signaling system as a therapeutic approach.

show abstract

“…However, after spinal cord transection TrkC has been shown to increase after two weeks (Qian DX 2011). Similarly, in a recent study assessing mRNA and protein changes after transection at 10 and 31 days post injury, whole spinal cord TrkB mRNA was elevated at 10 days post injury, and whole spinal cord NT3 and TrkB protein was elevated at 31 days post injury, with expression differences also observed depending on the location within the parenchyma of the spinal cord (Keeler BE 2012).…”

Section: Discussionmentioning

confidence: 82%

“…However, these have largely focused on time points of less than 6 weeks Liebl, Huang et al 2001;Liebl DJ 2001;Widenfalk J 2001;Qiao and Vizzard 2002;Gulino R 2004;Zvarova, Murray et al 2004;Qiao and Vizzard 2005;Qiao LY 2005;Qian DX 2006;Li XL 2007;Hajebrahimi, Mowla et al 2008;Qian, Zhang et al 2011;Qian DX 2011;Keeler BE 2012). Although valuable for elucidating the role of neurotrophin signaling in the first 6 weeks after SCI, these data are of uncertain value for relating to longer-term post-SCI function.…”

Section: Neurotrophins/trks Expression In Sensorimotor Circuits Aftermentioning

confidence: 99%

Gene expression analysis of neurotrophins, Trk receptors, and associated regulatory molecules after contusive spinal cord injury.

Hougland¹,

Tyler²

View full text Add to dashboard Cite

Traumatic spinal cord injury (SCI) results in changes to the anatomical, neurochemical, and physiological properties of cells in the central and peripheral nervous system. Neurotrophins, acting by binding to their cognate Trk receptors on target cell membranes, contribute to modulation of anatomical, neurochemical, and physiological properties of neurons in sensorimotor circuits in both the intact and injured spinal cord.Neurotrophin signaling is associated with many post-SCI changes including maladaptive plasticity leading to pain and autonomic dysreflexia, but also therapeutic approaches such as training-induced locomotor improvement. Here we characterize expression of mRNA for neurotrophins and Trk receptors in lumbar dorsal root ganglia (DRG) and spinal cord after two different severities of mid-thoracic injury and at 6 and 12 weeks post-SCI.There was complex regulation that differed with tissue, injury severity, and survival time, including reversals of regulation between 6 and 12 weeks, and the data suggest that natural regulation of neurotrophins in the spinal cord may continue for months after birth.iii Our assessments determined that a coordination of gene expression emerged at the 12 week post-SCI time point and bioinformatic analyses address possible mechanisms.Additionally, we sought to determine if the regulatory patterns we observed were perhaps due to an inflammatory molecule that mediated the coordinated expression pattern that we observed at 12 weeks post injury, and identified the chemokine CCL2 as a potential candidate gene.iv

show abstract

Expression of tyrosine kinase receptor C in the segments of the spinal cord and the cerebral cortex after cord transection in adult rats

Abstract: These results suggest that TrkC may be involved in neuroplasticity after SCI.

Cited by 5 publications

References 18 publications

Sustained delivery of neurotrophic factors to treat spinal cord injury

Sustained delivery of neurotrophic factors to treat spinal cord injury

The Transcriptional Response of Neurotrophins and Their Tyrosine Kinase Receptors in Lumbar Sensorimotor Circuits to Spinal Cord Contusion is Affected by Injury Severity and Survival Time

Gene expression analysis of neurotrophins, Trk receptors, and associated regulatory molecules after contusive spinal cord injury.

Contact Info

Product

Resources

About