Expression of undifferentiated embryonic cell transcription factor-1 (UTF1) in breast cancers and their matched normal tissues

Abstract

ObjectivesUndifferentiated embryonic cell transcription factor-1 (UTF1) plays a critical role in the developmental timing during embryonic development. However, there is little paper dealing with UTF1 expressed in adult tissues. In the present study, we evaluate the expression of UTF1 in breast cancer and its correlation with clinicopathological parameters.MethodsReal-time polymerase chain reaction (real-time PCR) was applied to detect the expression of UTF1 mRNA in the 55 pairs of samples of breast cancer tissues and match normal tissues. △△CT method was used to evaluate the relative quantity of target mRNA expression.ResultsAmong the 55 pairs of samples of breast cancer tissues and match normal tissues adjacent to the tumor, the UTF1 mRNA levels in normal tissues were significantly higher than those observed in breast cancer tissues (p < 0.001). UTF1 mRNA levels expression correlated with lymph node metastasis (p = 0.002) and tumor size (p < 0.001).ConclusionsExpression of UTF1 in breast cancer tissues were confirmed in this study. Decreased expression of UTF1 mRNA in breast cancer tissues was maybe one of the factors impact on tumorigenes in breast cancer patients.

Expression and clinical significance of undifferentiated embryonic cell transcription factor 1 in breast cancer

“…In this study, we found that the poor prognosis of breast cancer and the malignant biological characteristics of breast cancer cells were correlated with the high expression of UTF1, which plays a role as an oncogenic factor in breast cancer. However, this is in contrast to the results reported previously, which suggested that UTF1 expression is down-regulated in breast cancer and that UTF1 functions as a protective factor in breast tissue ( 16 ). It is worth noting that this paradox is also present in cervical cancer ( 11 , 17 ).…”

Genome wide methylation profiling of selected matched soft tissue sarcomas identifies methylation changes in metastatic and recurrent disease

“…Although differences in the gene expression and methylation signatures of the TME are associated with significant prognostic differences in patients with STSs 12 , such differences in the TME are unlikely to explain the results in our remainder samples, as most of our cases (10 of 14 paired cases) were over-represented by so-called 'cold tumours' , devoid of TILs. On the other hand, the role of UTF1 (undifferentiated embryonic cell transcription factor 1), which plays a role in stem-cell development 69 and carcinogenesis [70][71][72] , and NTRK3 in RMS has not been described. NTRK3 methylation has been reported in other tumours 73 and although tyrosine kinase inhibitors are widely available for NTRK-translocated tumours, the effect of these TRK inhibitors has not been explored in tumours with NTRK gain or loss due to methylation.…”